Wild-Type Isocitrate Dehydrogenase-Dependent Oxidative Decarboxylation and Reductive Carboxylation in Cancer and Their Clinical Significance

Wild-Type Isocitrate Dehydrogenase-Dependent Oxidative Decarboxylation and Reductive Carboxylation in Cancer and Their Clinical Significance

The human isocitrate dehydrogenase (IDH) gene encodes for the isoenzymes IDH1, 2, and 3, which catalyze the conversion of isocitrate and α-ketoglutarate (α-KG) and are required for normal mammalian metabolism. Isocitrate dehydrogenase 1 and 2 catalyze the reversible conversion of isocitrate to α-KG....

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Bibliographic Details
Main Authors: Qiwei He, Junxiong Chen, Zijing Xie, Zhenzhou Chen
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cancers
Subjects:
isocitrate dehydrogenase (IDH)
cancer metabolism
oxidative decarboxylation
reductive carboxylation
α-ketoglutarate (α-KG)
nicotinamide adenine dinucleotide phosphate (NADPH)
Online Access:https://www.mdpi.com/2072-6694/14/23/5779

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https://www.mdpi.com/2072-6694/14/23/5779

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