Microemulsions for enhancing drug delivery of hydrophilic drugs: Exploring various routes of administration
Microemulsions are a promising drug delivery system that can be used to enhance the bioavailability, solubility, and therapeutic efficacy of hydrophilic drugs. The downside of hydrophilic drugs is the poor solubility in lipid-based media; therefore, they require frequent dosing or high doses to achi...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
|
| Series: | Medicine in Drug Discovery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S259009862300012X |
| _version_ | 1797449404022521856 |
|---|---|
| author | Khushwant S. Yadav Govind Soni Deepak Choudhary Arushee Khanduri Ayush Bhandari Garima Joshi |
| author_facet | Khushwant S. Yadav Govind Soni Deepak Choudhary Arushee Khanduri Ayush Bhandari Garima Joshi |
| author_sort | Khushwant S. Yadav |
| collection | DOAJ |
| description | Microemulsions are a promising drug delivery system that can be used to enhance the bioavailability, solubility, and therapeutic efficacy of hydrophilic drugs. The downside of hydrophilic drugs is the poor solubility in lipid-based media; therefore, they require frequent dosing or high doses to achieve the therapeutic level. This may lead to unintended adverse effects and poor patient compliance Microemulsions can improve drug delivery by incorporating hydrophilic drugs within a thermodynamically stable and transparent oil-in-water emulsion. This can optimize the drug's solubility and permeability, leading to enhanced bioavailability and therapeutic efficacy. This review provides an insight to various routes of administration for delivering hydrophilic drugs using microemulsion. It will explore the use of microemulsion for oral, nasal, transdermal, and ocular delivery. The review also discusses the advantages, disadvantages and the physicochemical properties associated with each one of it. Overall, the article aims to provide a comprehensive overview of the use of microemulsions as a drug delivery system for hydrophilic drugs administered via different routes. |
| first_indexed | 2024-03-09T14:24:34Z |
| format | Article |
| id | doaj.art-2d9dabaa949d434dbb7fb865ef51bf3d |
| institution | Directory Open Access Journal |
| issn | 2590-0986 |
| language | English |
| last_indexed | 2024-03-09T14:24:34Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Medicine in Drug Discovery |
| spelling | doaj.art-2d9dabaa949d434dbb7fb865ef51bf3d2023-11-28T07:26:56ZengElsevierMedicine in Drug Discovery2590-09862023-12-0120100162Microemulsions for enhancing drug delivery of hydrophilic drugs: Exploring various routes of administrationKhushwant S. Yadav0Govind Soni1Deepak Choudhary2Arushee Khanduri3Ayush Bhandari4Garima Joshi5School of Pharmacy & Technology Management, SVKM’s NMIMS (Deemed to be University), Mumbai, India; Corresponding author at: SPPSPTM, SVKM’s NMIMS, Mumbai.A. P. J. Abdul Kalam University, Indore- Dewas Bypass Road, Village- Arandia, P.O. Vijay Nagar, Indore, MP, IndiaPharmaceutical Sciences, Mohanlal Sukhadia University, Udaipur, Rajasthan, IndiaSchool of Pharmacy & Technology Management, SVKM’s NMIMS (Deemed to be University), Mumbai, IndiaSchool of Pharmacy & Technology Management, SVKM’s NMIMS (Deemed to be University), Mumbai, IndiaPharmaceutical Sciences, Mohanlal Sukhadia University, Udaipur, Rajasthan, IndiaMicroemulsions are a promising drug delivery system that can be used to enhance the bioavailability, solubility, and therapeutic efficacy of hydrophilic drugs. The downside of hydrophilic drugs is the poor solubility in lipid-based media; therefore, they require frequent dosing or high doses to achieve the therapeutic level. This may lead to unintended adverse effects and poor patient compliance Microemulsions can improve drug delivery by incorporating hydrophilic drugs within a thermodynamically stable and transparent oil-in-water emulsion. This can optimize the drug's solubility and permeability, leading to enhanced bioavailability and therapeutic efficacy. This review provides an insight to various routes of administration for delivering hydrophilic drugs using microemulsion. It will explore the use of microemulsion for oral, nasal, transdermal, and ocular delivery. The review also discusses the advantages, disadvantages and the physicochemical properties associated with each one of it. Overall, the article aims to provide a comprehensive overview of the use of microemulsions as a drug delivery system for hydrophilic drugs administered via different routes.http://www.sciencedirect.com/science/article/pii/S259009862300012XMicroemulsionHydrophilic drugsOcularOralNasal |
| spellingShingle | Khushwant S. Yadav Govind Soni Deepak Choudhary Arushee Khanduri Ayush Bhandari Garima Joshi Microemulsions for enhancing drug delivery of hydrophilic drugs: Exploring various routes of administration Medicine in Drug Discovery Microemulsion Hydrophilic drugs Ocular Oral Nasal |
| title | Microemulsions for enhancing drug delivery of hydrophilic drugs: Exploring various routes of administration |
| title_full | Microemulsions for enhancing drug delivery of hydrophilic drugs: Exploring various routes of administration |
| title_fullStr | Microemulsions for enhancing drug delivery of hydrophilic drugs: Exploring various routes of administration |
| title_full_unstemmed | Microemulsions for enhancing drug delivery of hydrophilic drugs: Exploring various routes of administration |
| title_short | Microemulsions for enhancing drug delivery of hydrophilic drugs: Exploring various routes of administration |
| title_sort | microemulsions for enhancing drug delivery of hydrophilic drugs exploring various routes of administration |
| topic | Microemulsion Hydrophilic drugs Ocular Oral Nasal |
| url | http://www.sciencedirect.com/science/article/pii/S259009862300012X |
| work_keys_str_mv | AT khushwantsyadav microemulsionsforenhancingdrugdeliveryofhydrophilicdrugsexploringvariousroutesofadministration AT govindsoni microemulsionsforenhancingdrugdeliveryofhydrophilicdrugsexploringvariousroutesofadministration AT deepakchoudhary microemulsionsforenhancingdrugdeliveryofhydrophilicdrugsexploringvariousroutesofadministration AT arusheekhanduri microemulsionsforenhancingdrugdeliveryofhydrophilicdrugsexploringvariousroutesofadministration AT ayushbhandari microemulsionsforenhancingdrugdeliveryofhydrophilicdrugsexploringvariousroutesofadministration AT garimajoshi microemulsionsforenhancingdrugdeliveryofhydrophilicdrugsexploringvariousroutesofadministration |