Differential Expression of microRNAs in Serum of Patients with Chronic Painful Polyneuropathy and Healthy Age-Matched Controls
Polyneuropathies (PNP) are the most common type of disorder of the peripheral nervous system in adults. However, information on microRNA expression in PNP is lacking. Following microRNA sequencing, we compared the expression of microRNAs in the serum of patients experiencing chronic painful PNP with...
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| Format: | Article |
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MDPI AG
2023-03-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/3/764 |
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| author | Antonio Pellegrino Sophie-Charlotte Fabig Dilara Kersebaum Philipp Hüllemann Ralf Baron Toralf Roch Nina Babel Harald Seitz |
| author_facet | Antonio Pellegrino Sophie-Charlotte Fabig Dilara Kersebaum Philipp Hüllemann Ralf Baron Toralf Roch Nina Babel Harald Seitz |
| author_sort | Antonio Pellegrino |
| collection | DOAJ |
| description | Polyneuropathies (PNP) are the most common type of disorder of the peripheral nervous system in adults. However, information on microRNA expression in PNP is lacking. Following microRNA sequencing, we compared the expression of microRNAs in the serum of patients experiencing chronic painful PNP with healthy age-matched controls. We have been able to identify four microRNAs (<i>hsa</i>-miR-3135b, <i>hsa</i>-miR-584-5p, <i>hsa</i>-miR-12136, and <i>hsa</i>-miR-550a-3p) that provide possible molecular links between degenerative processes, blood flow regulation, and signal transduction, that eventually lead to PNP. In addition, these microRNAs are discussed regarding the targeting of proteins that are involved in high blood flow/pressure and neural activity dysregulations/disbalances, presumably resulting in PNP-typical symptoms such as chronical numbness/pain. Within our study, we have identified four microRNAs that may serve as potential novel biomarkers of chronic painful PNP, and that may potentially bear therapeutic implications. |
| first_indexed | 2024-03-11T06:53:17Z |
| format | Article |
| id | doaj.art-2d9e38fdd667439798f2a65b9be09eab |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T06:53:17Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-2d9e38fdd667439798f2a65b9be09eab2023-11-17T09:45:17ZengMDPI AGBiomedicines2227-90592023-03-0111376410.3390/biomedicines11030764Differential Expression of microRNAs in Serum of Patients with Chronic Painful Polyneuropathy and Healthy Age-Matched ControlsAntonio Pellegrino0Sophie-Charlotte Fabig1Dilara Kersebaum2Philipp Hüllemann3Ralf Baron4Toralf Roch5Nina Babel6Harald Seitz7Fraunhofer Institute for Cell Therapy and Immunology, Branch Bioanalytics and Bioprocesses (IZI-BB), 14476 Potsdam, GermanyDivision of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein, 24105 Kiel, GermanyDivision of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein, 24105 Kiel, GermanyDivision of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein, 24105 Kiel, GermanyDivision of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein, 24105 Kiel, GermanyBerlin Institute of Health at Charité—University Clinic Berlin, BIH Center for Regenerative Therapies, 13353 Berlin, GermanyBerlin Institute of Health at Charité—University Clinic Berlin, BIH Center for Regenerative Therapies, 13353 Berlin, GermanyFraunhofer Institute for Cell Therapy and Immunology, Branch Bioanalytics and Bioprocesses (IZI-BB), 14476 Potsdam, GermanyPolyneuropathies (PNP) are the most common type of disorder of the peripheral nervous system in adults. However, information on microRNA expression in PNP is lacking. Following microRNA sequencing, we compared the expression of microRNAs in the serum of patients experiencing chronic painful PNP with healthy age-matched controls. We have been able to identify four microRNAs (<i>hsa</i>-miR-3135b, <i>hsa</i>-miR-584-5p, <i>hsa</i>-miR-12136, and <i>hsa</i>-miR-550a-3p) that provide possible molecular links between degenerative processes, blood flow regulation, and signal transduction, that eventually lead to PNP. In addition, these microRNAs are discussed regarding the targeting of proteins that are involved in high blood flow/pressure and neural activity dysregulations/disbalances, presumably resulting in PNP-typical symptoms such as chronical numbness/pain. Within our study, we have identified four microRNAs that may serve as potential novel biomarkers of chronic painful PNP, and that may potentially bear therapeutic implications.https://www.mdpi.com/2227-9059/11/3/764differential expressionmicroRNAserumchronic painpolyneuropathy |
| spellingShingle | Antonio Pellegrino Sophie-Charlotte Fabig Dilara Kersebaum Philipp Hüllemann Ralf Baron Toralf Roch Nina Babel Harald Seitz Differential Expression of microRNAs in Serum of Patients with Chronic Painful Polyneuropathy and Healthy Age-Matched Controls Biomedicines differential expression microRNA serum chronic pain polyneuropathy |
| title | Differential Expression of microRNAs in Serum of Patients with Chronic Painful Polyneuropathy and Healthy Age-Matched Controls |
| title_full | Differential Expression of microRNAs in Serum of Patients with Chronic Painful Polyneuropathy and Healthy Age-Matched Controls |
| title_fullStr | Differential Expression of microRNAs in Serum of Patients with Chronic Painful Polyneuropathy and Healthy Age-Matched Controls |
| title_full_unstemmed | Differential Expression of microRNAs in Serum of Patients with Chronic Painful Polyneuropathy and Healthy Age-Matched Controls |
| title_short | Differential Expression of microRNAs in Serum of Patients with Chronic Painful Polyneuropathy and Healthy Age-Matched Controls |
| title_sort | differential expression of micrornas in serum of patients with chronic painful polyneuropathy and healthy age matched controls |
| topic | differential expression microRNA serum chronic pain polyneuropathy |
| url | https://www.mdpi.com/2227-9059/11/3/764 |
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