Moderate Caloric Restriction Partially Improved Oxidative Stress Markers in Obese Humans
Oxidative stress and inflammation are implicated in obesity. Therefore, we investigated whether moderate and short-term calorie restriction (CR) reflects a real-life situation, mediates weight loss, and improves oxidative stress markers. We analyzed oxidative stress markers in patients with obesity...
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MDPI AG
2021-06-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/7/1018 |
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| author | Dominika Kanikowska Alina Kanikowska Ewelina Swora-Cwynar Marian Grzymisławski Maki Sato Andrzej Bręborowicz Janusz Witowski Katarzyna Korybalska |
| author_facet | Dominika Kanikowska Alina Kanikowska Ewelina Swora-Cwynar Marian Grzymisławski Maki Sato Andrzej Bręborowicz Janusz Witowski Katarzyna Korybalska |
| author_sort | Dominika Kanikowska |
| collection | DOAJ |
| description | Oxidative stress and inflammation are implicated in obesity. Therefore, we investigated whether moderate and short-term calorie restriction (CR) reflects a real-life situation, mediates weight loss, and improves oxidative stress markers. We analyzed oxidative stress markers in patients with obesity undergoing moderate CR. Serum oxidative stress markers (myeloperoxidase (MPO), superoxide dismutase (SOD), catalase, total antioxidant status (TAS), and reactive oxygen species (ROS) (generation by endothelial cells in vitro)) were measured in 53 subjects (mean BMI 37.8 ± 5.9 kg/m<sup>2</sup>) who underwent 8 weeks of CR, which included a reduction of 300–500 kcal/day. MPO was the most CR-sensitive parameter. The mean level of serum MPO in patients with obesity was 20% higher than that in post CR intervention (<i>p</i> < 0.001). SOD increased by 12% after CR (<i>p</i> < 0.05), which was largely due to the improvement in glucose tolerance and the reduction in insulin resistance after CR. Other tested parameters were not modified during the treatment. CR resulted in an expected decrease in body weight (by 5.9 ± 4.6 kg, <i>p</i> < 0.0001) and other anthropometric parameters. Additionally, it was accompanied by a significant change in hsCRP, hsTNF alpha, hsIL-6, leptin (all <i>p</i> < 0.0001), and HOMA-IR (<i>p</i> < 0.05). Cardiovascular and metabolic parameters were also partially improved. Short-term, moderate CR partially improves antioxidant capacity but is enough to substantially change anthropometric parameters in obese patients. Our observations indicate that mimicking real-life situations and low-cost dietary intervention can be successfully implemented in obesity treatment with a simultaneous moderate effect on antioxidant status. |
| first_indexed | 2024-03-09T04:55:58Z |
| format | Article |
| id | doaj.art-2d9f3fe3609541d8bc039f64c61fa176 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T04:55:58Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-2d9f3fe3609541d8bc039f64c61fa1762023-12-03T13:05:23ZengMDPI AGAntioxidants2076-39212021-06-01107101810.3390/antiox10071018Moderate Caloric Restriction Partially Improved Oxidative Stress Markers in Obese HumansDominika Kanikowska0Alina Kanikowska1Ewelina Swora-Cwynar2Marian Grzymisławski3Maki Sato4Andrzej Bręborowicz5Janusz Witowski6Katarzyna Korybalska7Department of Pathophysiology, Poznan University of Medical Sciences, 60-806 Poznań, PolandDepartment of Internal Diseases, Metabolism and Nutrition, Poznań University of Medical Science, 60-355 Poznań, PolandDepartment of Internal Diseases, Metabolism and Nutrition, Poznań University of Medical Science, 60-355 Poznań, PolandDepartment of Internal Diseases, Metabolism and Nutrition, Poznań University of Medical Science, 60-355 Poznań, PolandDepartment of Physiology, Institutional Research, Aichi Medical University School of Medicine, Aichi Medical University, Aichi 480-1195, JapanDepartment of Pathophysiology, Poznan University of Medical Sciences, 60-806 Poznań, PolandDepartment of Pathophysiology, Poznan University of Medical Sciences, 60-806 Poznań, PolandDepartment of Pathophysiology, Poznan University of Medical Sciences, 60-806 Poznań, PolandOxidative stress and inflammation are implicated in obesity. Therefore, we investigated whether moderate and short-term calorie restriction (CR) reflects a real-life situation, mediates weight loss, and improves oxidative stress markers. We analyzed oxidative stress markers in patients with obesity undergoing moderate CR. Serum oxidative stress markers (myeloperoxidase (MPO), superoxide dismutase (SOD), catalase, total antioxidant status (TAS), and reactive oxygen species (ROS) (generation by endothelial cells in vitro)) were measured in 53 subjects (mean BMI 37.8 ± 5.9 kg/m<sup>2</sup>) who underwent 8 weeks of CR, which included a reduction of 300–500 kcal/day. MPO was the most CR-sensitive parameter. The mean level of serum MPO in patients with obesity was 20% higher than that in post CR intervention (<i>p</i> < 0.001). SOD increased by 12% after CR (<i>p</i> < 0.05), which was largely due to the improvement in glucose tolerance and the reduction in insulin resistance after CR. Other tested parameters were not modified during the treatment. CR resulted in an expected decrease in body weight (by 5.9 ± 4.6 kg, <i>p</i> < 0.0001) and other anthropometric parameters. Additionally, it was accompanied by a significant change in hsCRP, hsTNF alpha, hsIL-6, leptin (all <i>p</i> < 0.0001), and HOMA-IR (<i>p</i> < 0.05). Cardiovascular and metabolic parameters were also partially improved. Short-term, moderate CR partially improves antioxidant capacity but is enough to substantially change anthropometric parameters in obese patients. Our observations indicate that mimicking real-life situations and low-cost dietary intervention can be successfully implemented in obesity treatment with a simultaneous moderate effect on antioxidant status.https://www.mdpi.com/2076-3921/10/7/1018oxidative stressobesitymoderate calorie restrictionMPO |
| spellingShingle | Dominika Kanikowska Alina Kanikowska Ewelina Swora-Cwynar Marian Grzymisławski Maki Sato Andrzej Bręborowicz Janusz Witowski Katarzyna Korybalska Moderate Caloric Restriction Partially Improved Oxidative Stress Markers in Obese Humans Antioxidants oxidative stress obesity moderate calorie restriction MPO |
| title | Moderate Caloric Restriction Partially Improved Oxidative Stress Markers in Obese Humans |
| title_full | Moderate Caloric Restriction Partially Improved Oxidative Stress Markers in Obese Humans |
| title_fullStr | Moderate Caloric Restriction Partially Improved Oxidative Stress Markers in Obese Humans |
| title_full_unstemmed | Moderate Caloric Restriction Partially Improved Oxidative Stress Markers in Obese Humans |
| title_short | Moderate Caloric Restriction Partially Improved Oxidative Stress Markers in Obese Humans |
| title_sort | moderate caloric restriction partially improved oxidative stress markers in obese humans |
| topic | oxidative stress obesity moderate calorie restriction MPO |
| url | https://www.mdpi.com/2076-3921/10/7/1018 |
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