Genetic diversity and forensic application of Y-filer STRs in four major ethnic groups of Pakistan
Abstract 17 Y-chromosomal STRs which are part of the Yfiler Amplification Kit were investigated in 493 unrelated Pakistani individuals belonging to the Punjabi, Sindhi, Baloch, and Pathan ethnic groups. We have assessed the forensic parameters and population genetic structure for each group. Among t...
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | BMC Genomics |
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| Online Access: | https://doi.org/10.1186/s12864-022-09028-z |
| _version_ | 1811190456536530944 |
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| author | Muhammad Salman Ikram Tahir Mehmood Allah Rakha Sareen Akhtar Muhammad Imran Mahmood Khan Wedad Saeed Al-Qahtani Fatmah Ahmed Safhi Sibte Hadi Chuan-Chao Wang Atif Adnan |
| author_facet | Muhammad Salman Ikram Tahir Mehmood Allah Rakha Sareen Akhtar Muhammad Imran Mahmood Khan Wedad Saeed Al-Qahtani Fatmah Ahmed Safhi Sibte Hadi Chuan-Chao Wang Atif Adnan |
| author_sort | Muhammad Salman Ikram |
| collection | DOAJ |
| description | Abstract 17 Y-chromosomal STRs which are part of the Yfiler Amplification Kit were investigated in 493 unrelated Pakistani individuals belonging to the Punjabi, Sindhi, Baloch, and Pathan ethnic groups. We have assessed the forensic parameters and population genetic structure for each group. Among the 493 unrelated individuals from four ethnic groups (128 Baloch, 122 Pathan, 108 Punjabi, and 135 Sindhi), 82 haplotypes were observed with haplotype diversity (HD) of 0.9906 in Baloch, 102 haplotypes with HD value of 0.9957 in Pathans, 80 haplotypes with HD value of 0.9924 in Punjabi, and 105 haplotypes with HD value of 0.9945 in the Sindhi population. The overall gene diversity for Baloch, Pathan, Punjabi, and Sindhi populations was 0.6367, 0.6479, 0.6657, and 0.6112, respectively. The results had shown us that Pakistani populations do not have a unique set of genes but share the genetic affinity with regional (Central Asia and Northern India) populations. The observed low gene diversity (heterozygosity) values may be because of endogamy trends and this observation is equally supported by the results of forensic parameters which are mostly static across 4 combinations (minimal STRs, extended 11 Y-STRs, Powerplex 12 Y System, and Yfiler 17 Y-STRs) of STRs in these four populations. |
| first_indexed | 2024-04-11T14:50:26Z |
| format | Article |
| id | doaj.art-2da0b465c3174dba9280cf794f3f7989 |
| institution | Directory Open Access Journal |
| issn | 1471-2164 |
| language | English |
| last_indexed | 2024-04-11T14:50:26Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genomics |
| spelling | doaj.art-2da0b465c3174dba9280cf794f3f79892022-12-22T04:17:27ZengBMCBMC Genomics1471-21642022-11-0123111110.1186/s12864-022-09028-zGenetic diversity and forensic application of Y-filer STRs in four major ethnic groups of PakistanMuhammad Salman Ikram0Tahir Mehmood1Allah Rakha2Sareen Akhtar3Muhammad Imran Mahmood Khan4Wedad Saeed Al-Qahtani5Fatmah Ahmed Safhi6Sibte Hadi7Chuan-Chao Wang8Atif Adnan9Department of Anthropology and Ethnology, Institute of Anthropology, School of Sociology and Anthropology, Xiamen UniversityInstitute of Chemistry, University of SargodhaDepartment of Forensic Sciences, University of Health SciencesDepartment of Forensic Sciences, University of Health SciencesInternational Committee of Red CrossDepartment of Forensic Sciences, College of Criminal Justice, Naïf Arab University of Security SciencesDepartment of Biology, College of Science, Princess Nourah bint Abdulrahman UniversityDepartment of Forensic Sciences, College of Criminal Justice, Naïf Arab University of Security SciencesDepartment of Anthropology and Ethnology, Institute of Anthropology, School of Sociology and Anthropology, Xiamen UniversityDepartment of Anthropology and Ethnology, Institute of Anthropology, School of Sociology and Anthropology, Xiamen UniversityAbstract 17 Y-chromosomal STRs which are part of the Yfiler Amplification Kit were investigated in 493 unrelated Pakistani individuals belonging to the Punjabi, Sindhi, Baloch, and Pathan ethnic groups. We have assessed the forensic parameters and population genetic structure for each group. Among the 493 unrelated individuals from four ethnic groups (128 Baloch, 122 Pathan, 108 Punjabi, and 135 Sindhi), 82 haplotypes were observed with haplotype diversity (HD) of 0.9906 in Baloch, 102 haplotypes with HD value of 0.9957 in Pathans, 80 haplotypes with HD value of 0.9924 in Punjabi, and 105 haplotypes with HD value of 0.9945 in the Sindhi population. The overall gene diversity for Baloch, Pathan, Punjabi, and Sindhi populations was 0.6367, 0.6479, 0.6657, and 0.6112, respectively. The results had shown us that Pakistani populations do not have a unique set of genes but share the genetic affinity with regional (Central Asia and Northern India) populations. The observed low gene diversity (heterozygosity) values may be because of endogamy trends and this observation is equally supported by the results of forensic parameters which are mostly static across 4 combinations (minimal STRs, extended 11 Y-STRs, Powerplex 12 Y System, and Yfiler 17 Y-STRs) of STRs in these four populations.https://doi.org/10.1186/s12864-022-09028-zPunjabiSindhiBalochPathanYfiler amplification kitForensic and population genetic |
| spellingShingle | Muhammad Salman Ikram Tahir Mehmood Allah Rakha Sareen Akhtar Muhammad Imran Mahmood Khan Wedad Saeed Al-Qahtani Fatmah Ahmed Safhi Sibte Hadi Chuan-Chao Wang Atif Adnan Genetic diversity and forensic application of Y-filer STRs in four major ethnic groups of Pakistan BMC Genomics Punjabi Sindhi Baloch Pathan Yfiler amplification kit Forensic and population genetic |
| title | Genetic diversity and forensic application of Y-filer STRs in four major ethnic groups of Pakistan |
| title_full | Genetic diversity and forensic application of Y-filer STRs in four major ethnic groups of Pakistan |
| title_fullStr | Genetic diversity and forensic application of Y-filer STRs in four major ethnic groups of Pakistan |
| title_full_unstemmed | Genetic diversity and forensic application of Y-filer STRs in four major ethnic groups of Pakistan |
| title_short | Genetic diversity and forensic application of Y-filer STRs in four major ethnic groups of Pakistan |
| title_sort | genetic diversity and forensic application of y filer strs in four major ethnic groups of pakistan |
| topic | Punjabi Sindhi Baloch Pathan Yfiler amplification kit Forensic and population genetic |
| url | https://doi.org/10.1186/s12864-022-09028-z |
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