Occurrence rate of rifampicin-resistant Mycobacterium tuberculosis in patients attending chest clinics in selected hospitals in Akure metropolis
Background: The increase in incidence of Mycobacterium tuberculosis (MTB) and emergence of drug resistant strains of MTB is a serious issue especially in developing communities. The aim of this study is to investigate occurrence rate of rifampicin-resistant Mycobacterium tuberculosis in patients att...
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| Format: | Article |
| Language: | English |
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Zagazig University, Faculty of Medicine
2022-10-01
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| Series: | Microbes and Infectious Diseases |
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| Online Access: | https://mid.journals.ekb.eg/article_216430_435e9d316cde5cac89050df62d6b6a6d.pdf |
| _version_ | 1811194074046136320 |
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| author | Saheed Jegede TINUOLA ADEBOLU BABAYEMI OLADEJO |
| author_facet | Saheed Jegede TINUOLA ADEBOLU BABAYEMI OLADEJO |
| author_sort | Saheed Jegede |
| collection | DOAJ |
| description | Background: The increase in incidence of Mycobacterium tuberculosis (MTB) and emergence of drug resistant strains of MTB is a serious issue especially in developing communities. The aim of this study is to investigate occurrence rate of rifampicin-resistant Mycobacterium tuberculosis in patients attending chest clinics in selected hospitals in Akure metropolis Ondo State, Nigeria. Methods: A total of five hundred (500) sputum samples were collected from patients attending selected chest clinics in Akure metropolis and a specially designed questionnaire was used to collect the socio-demographic data of the individuals recruited for the study. The collected sputum samples were analyzed using GeneXpert machine (Cepheid, Model GX-IV) to detect MTB rifampicin resistance. Results: 51(10.2 %) of the 500 patients screened were positive for MTB while 8(15.7 %) of the MTB positive patients had rifampicin-resistant MTB. The occurrence of rifampicin-resistant MTB was higher in males (23.8 %) than in females (10.0 %). It was also higher among the age range of 20-31 years with percentage of (33.3 %) and higher among singles (87.5 %) than the married (2.3 %). Rifampicin-resistant MTB was higher among the illiterate (20 %). Conclusion: It is imperative that the health policy makers and government should increase the awareness campaign on tuberculosis prevention and also encourage more studies for the development of novel and more effective tuberculosis’ drugs by financing the project. |
| first_indexed | 2024-04-12T00:19:59Z |
| format | Article |
| id | doaj.art-2da34988afdb489ca0ce95cff8db4eee |
| institution | Directory Open Access Journal |
| issn | 2682-4132 2682-4140 |
| language | English |
| last_indexed | 2024-04-12T00:19:59Z |
| publishDate | 2022-10-01 |
| publisher | Zagazig University, Faculty of Medicine |
| record_format | Article |
| series | Microbes and Infectious Diseases |
| spelling | doaj.art-2da34988afdb489ca0ce95cff8db4eee2022-12-22T03:55:44ZengZagazig University, Faculty of MedicineMicrobes and Infectious Diseases2682-41322682-41402022-10-01341026103110.21608/mid.2022.107695.1221216430Occurrence rate of rifampicin-resistant Mycobacterium tuberculosis in patients attending chest clinics in selected hospitals in Akure metropolisSaheed Jegede0TINUOLA ADEBOLU1BABAYEMI OLADEJO2DEPARTMENT OF MICROBIOLOGY, FEDERAL UNIVERSITY OF TECHNOLOGY, AKUREDEPARTMENT OF MICROBIOLOGY, FEDERAL UNIVERSITY, AKURE, NIGERIADEPARTMENT OF MICROBIOLOGY, FEDERAL UNIVERSITY OF TECHNOLOGY, AKURE, NIGERIABackground: The increase in incidence of Mycobacterium tuberculosis (MTB) and emergence of drug resistant strains of MTB is a serious issue especially in developing communities. The aim of this study is to investigate occurrence rate of rifampicin-resistant Mycobacterium tuberculosis in patients attending chest clinics in selected hospitals in Akure metropolis Ondo State, Nigeria. Methods: A total of five hundred (500) sputum samples were collected from patients attending selected chest clinics in Akure metropolis and a specially designed questionnaire was used to collect the socio-demographic data of the individuals recruited for the study. The collected sputum samples were analyzed using GeneXpert machine (Cepheid, Model GX-IV) to detect MTB rifampicin resistance. Results: 51(10.2 %) of the 500 patients screened were positive for MTB while 8(15.7 %) of the MTB positive patients had rifampicin-resistant MTB. The occurrence of rifampicin-resistant MTB was higher in males (23.8 %) than in females (10.0 %). It was also higher among the age range of 20-31 years with percentage of (33.3 %) and higher among singles (87.5 %) than the married (2.3 %). Rifampicin-resistant MTB was higher among the illiterate (20 %). Conclusion: It is imperative that the health policy makers and government should increase the awareness campaign on tuberculosis prevention and also encourage more studies for the development of novel and more effective tuberculosis’ drugs by financing the project.https://mid.journals.ekb.eg/article_216430_435e9d316cde5cac89050df62d6b6a6d.pdfmycobacterium tuberculosis (mtb)rifampicin-resistantsocio-demographicgendertuberculosis |
| spellingShingle | Saheed Jegede TINUOLA ADEBOLU BABAYEMI OLADEJO Occurrence rate of rifampicin-resistant Mycobacterium tuberculosis in patients attending chest clinics in selected hospitals in Akure metropolis Microbes and Infectious Diseases mycobacterium tuberculosis (mtb) rifampicin-resistant socio-demographic gender tuberculosis |
| title | Occurrence rate of rifampicin-resistant Mycobacterium tuberculosis in patients attending chest clinics in selected hospitals in Akure metropolis |
| title_full | Occurrence rate of rifampicin-resistant Mycobacterium tuberculosis in patients attending chest clinics in selected hospitals in Akure metropolis |
| title_fullStr | Occurrence rate of rifampicin-resistant Mycobacterium tuberculosis in patients attending chest clinics in selected hospitals in Akure metropolis |
| title_full_unstemmed | Occurrence rate of rifampicin-resistant Mycobacterium tuberculosis in patients attending chest clinics in selected hospitals in Akure metropolis |
| title_short | Occurrence rate of rifampicin-resistant Mycobacterium tuberculosis in patients attending chest clinics in selected hospitals in Akure metropolis |
| title_sort | occurrence rate of rifampicin resistant mycobacterium tuberculosis in patients attending chest clinics in selected hospitals in akure metropolis |
| topic | mycobacterium tuberculosis (mtb) rifampicin-resistant socio-demographic gender tuberculosis |
| url | https://mid.journals.ekb.eg/article_216430_435e9d316cde5cac89050df62d6b6a6d.pdf |
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