Ribosomal Protein L10: From Function to Dysfunction
Eukaryotic cytoplasmic ribosomes are highly structured macromolecular complexes made up of four different ribosomal RNAs (rRNAs) and 80 ribosomal proteins (RPs), which play a central role in the decoding of genetic code for the synthesis of new proteins. Over the past 25 years, studies on yeast and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/11/2503 |
| _version_ | 1827701887101566976 |
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| author | Daniela Pollutri Marianna Penzo |
| author_facet | Daniela Pollutri Marianna Penzo |
| author_sort | Daniela Pollutri |
| collection | DOAJ |
| description | Eukaryotic cytoplasmic ribosomes are highly structured macromolecular complexes made up of four different ribosomal RNAs (rRNAs) and 80 ribosomal proteins (RPs), which play a central role in the decoding of genetic code for the synthesis of new proteins. Over the past 25 years, studies on yeast and human models have made it possible to identify <i>RPL10</i> (ribosomal protein L10 gene), which is a constituent of the large subunit of the ribosome, as an important player in the final stages of ribosome biogenesis and in ribosome function. Here, we reviewed the literature to give an overview of the role of RPL10 in physiologic and pathologic processes, including inherited disease and cancer. |
| first_indexed | 2024-03-10T14:44:37Z |
| format | Article |
| id | doaj.art-2da40ff7bb084d9f838488d78eb4b974 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T14:44:37Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-2da40ff7bb084d9f838488d78eb4b9742023-11-20T21:29:42ZengMDPI AGCells2073-44092020-11-01911250310.3390/cells9112503Ribosomal Protein L10: From Function to DysfunctionDaniela Pollutri0Marianna Penzo1Department of Experimental, Diagnostic and Specialty Medicine Alma Mater Studiorum University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDepartment of Experimental, Diagnostic and Specialty Medicine Alma Mater Studiorum University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyEukaryotic cytoplasmic ribosomes are highly structured macromolecular complexes made up of four different ribosomal RNAs (rRNAs) and 80 ribosomal proteins (RPs), which play a central role in the decoding of genetic code for the synthesis of new proteins. Over the past 25 years, studies on yeast and human models have made it possible to identify <i>RPL10</i> (ribosomal protein L10 gene), which is a constituent of the large subunit of the ribosome, as an important player in the final stages of ribosome biogenesis and in ribosome function. Here, we reviewed the literature to give an overview of the role of RPL10 in physiologic and pathologic processes, including inherited disease and cancer.https://www.mdpi.com/2073-4409/9/11/2503RPL10ribosomecancerribosomopathyrare diseasetranslation |
| spellingShingle | Daniela Pollutri Marianna Penzo Ribosomal Protein L10: From Function to Dysfunction Cells RPL10 ribosome cancer ribosomopathy rare disease translation |
| title | Ribosomal Protein L10: From Function to Dysfunction |
| title_full | Ribosomal Protein L10: From Function to Dysfunction |
| title_fullStr | Ribosomal Protein L10: From Function to Dysfunction |
| title_full_unstemmed | Ribosomal Protein L10: From Function to Dysfunction |
| title_short | Ribosomal Protein L10: From Function to Dysfunction |
| title_sort | ribosomal protein l10 from function to dysfunction |
| topic | RPL10 ribosome cancer ribosomopathy rare disease translation |
| url | https://www.mdpi.com/2073-4409/9/11/2503 |
| work_keys_str_mv | AT danielapollutri ribosomalproteinl10fromfunctiontodysfunction AT mariannapenzo ribosomalproteinl10fromfunctiontodysfunction |