Development of a latent dementia index in the aging, demographics, and memory study: Validation and measurement invariance by sex
Abstract Latent variable models can create a latent dementia index (LDI) using cognitive and functional ability to approximate dementia likelihood. The LDI approach has been applied across diverse cohorts. It is unclear whether sex affects its measurement properties. We use Wave A (2001–2003) of the...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-04-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/dad2.12433 |
| _version_ | 1797317304843763712 |
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| author | Joseph Saenz Christopher R. Beam Alice J. Kim |
| author_facet | Joseph Saenz Christopher R. Beam Alice J. Kim |
| author_sort | Joseph Saenz |
| collection | DOAJ |
| description | Abstract Latent variable models can create a latent dementia index (LDI) using cognitive and functional ability to approximate dementia likelihood. The LDI approach has been applied across diverse cohorts. It is unclear whether sex affects its measurement properties. We use Wave A (2001–2003) of the Aging, Demographics, and Memory Study (n = 856). Multiple group confirmatory factor analysis (CFA) was used to test measurement invariance (MI) using informant‐reported functional ability and cognitive performance tasks, which we group into verbal, nonverbal, and memory. Partial scalar invariance was found, allowing for testing sex differences in LDI means (MDiff = 0.38). The LDI correlated with consensus panel dementia diagnosis, Mini‐Mental State Examination (MMSE), and dementia risk factors (low education, advanced age, and apolipoprotein ε4 [APOE‐ε4] status) for men and women. The LDI validly captures dementia likelihood to permit estimation of sex differences. LDI sex differences indicate higher dementia likelihood in women, potentially due to social, environmental, and biological factors. |
| first_indexed | 2024-03-08T03:32:59Z |
| format | Article |
| id | doaj.art-2da7190cebf445b48f2d71da4c1a5ede |
| institution | Directory Open Access Journal |
| issn | 2352-8729 |
| language | English |
| last_indexed | 2024-03-08T03:32:59Z |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj.art-2da7190cebf445b48f2d71da4c1a5ede2024-02-10T14:10:32ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292023-04-01152n/an/a10.1002/dad2.12433Development of a latent dementia index in the aging, demographics, and memory study: Validation and measurement invariance by sexJoseph Saenz0Christopher R. Beam1Alice J. Kim2Edson College of Nursing and Health Innovation Arizona State University Phoenix Arizona USADavis School of Gerontology University of Southern California Los Angeles California USADavis School of Gerontology University of Southern California Los Angeles California USAAbstract Latent variable models can create a latent dementia index (LDI) using cognitive and functional ability to approximate dementia likelihood. The LDI approach has been applied across diverse cohorts. It is unclear whether sex affects its measurement properties. We use Wave A (2001–2003) of the Aging, Demographics, and Memory Study (n = 856). Multiple group confirmatory factor analysis (CFA) was used to test measurement invariance (MI) using informant‐reported functional ability and cognitive performance tasks, which we group into verbal, nonverbal, and memory. Partial scalar invariance was found, allowing for testing sex differences in LDI means (MDiff = 0.38). The LDI correlated with consensus panel dementia diagnosis, Mini‐Mental State Examination (MMSE), and dementia risk factors (low education, advanced age, and apolipoprotein ε4 [APOE‐ε4] status) for men and women. The LDI validly captures dementia likelihood to permit estimation of sex differences. LDI sex differences indicate higher dementia likelihood in women, potentially due to social, environmental, and biological factors.https://doi.org/10.1002/dad2.12433dementiaHRSlatent variablemeasurementsex differences |
| spellingShingle | Joseph Saenz Christopher R. Beam Alice J. Kim Development of a latent dementia index in the aging, demographics, and memory study: Validation and measurement invariance by sex Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring dementia HRS latent variable measurement sex differences |
| title | Development of a latent dementia index in the aging, demographics, and memory study: Validation and measurement invariance by sex |
| title_full | Development of a latent dementia index in the aging, demographics, and memory study: Validation and measurement invariance by sex |
| title_fullStr | Development of a latent dementia index in the aging, demographics, and memory study: Validation and measurement invariance by sex |
| title_full_unstemmed | Development of a latent dementia index in the aging, demographics, and memory study: Validation and measurement invariance by sex |
| title_short | Development of a latent dementia index in the aging, demographics, and memory study: Validation and measurement invariance by sex |
| title_sort | development of a latent dementia index in the aging demographics and memory study validation and measurement invariance by sex |
| topic | dementia HRS latent variable measurement sex differences |
| url | https://doi.org/10.1002/dad2.12433 |
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