Group A streptococci induce stronger M protein-fibronectin interaction when specific human antibodies are bound

Group A streptococci induce stronger M protein-fibronectin interaction when specific human antibodies are bound

Group A streptococcus (GAS) is a highly adapted, human-specific pathogen that is known to manipulate the immune system through various mechanisms. GAS’ M protein constitutes a primary target of the immune system due to its spatial configuration and dominance on the bacterial surface. Antibody respon...

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Bibliographic Details
Main Authors: Sebastian Wrighton, Vibha Kumra Ahnlide, Oscar André, Wael Bahnan, Pontus Nordenfelt
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Microbiology
Subjects:
antibodies
co-evolution
immune subversion
group A – beta hemolytic streptococcus
fibronectin
adaptive immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1069789/full

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