Interspecies Comparisons of the Effects of Potential Antiviral 3-Amidinophenylalanine Derivatives on Cytochrome P450 1A2 Isoenzyme

Interspecies Comparisons of the Effects of Potential Antiviral 3-Amidinophenylalanine Derivatives on Cytochrome P450 1A2 Isoenzyme

In vitro models of animals vulnerable to SARS-CoV-2 infection can support the characterization of effective antiviral drugs, such as synthetic inhibitors of the transmembrane protease serine 2 (TMPRSS2). Changes in cytochrome P450 (CYP) 1A2 activities in the presence of the potential TMPRSS2/matript...

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Bibliographic Details
Main Authors: Zsófia Fedor, Anna Szentkirályi-Tóth, Gábor Nagy, Zoltán Szimrók, Eszter Varga, Anna Pászti, Zoltán Pászti, Ákos Jerzsele, Oliver Pilgram, Torsten Steinmetzer, Gábor Mátis, Zsuzsanna Neogrády, Erzsébet Pászti-Gere
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Veterinary Sciences
Subjects:
3-amidinophenylalanine
beagle
cynomolgus monkey microsome
SARS-CoV-2
CYP1A2
hepatocytes
Online Access:https://www.mdpi.com/2306-7381/9/4/156

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https://www.mdpi.com/2306-7381/9/4/156

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