Effect of Letrozole, Berberine, or Their Combination for Infertility in Women with Polycystic Ovary Syndrome: Statistical Analysis Plan for a Multicenter Randomized Controlled Trial
Introduction: Letrozole showed higher ovulation and live birth rates than clomiphene in infertile women with polycystic ovary syndrome (PCOS). Berberine, a major active component of Chinese herbal medicine rhizomacoptidis, has been used to improve insulin resistance to facilitate ovulation induction...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-11-01
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| Series: | World Journal of Traditional Chinese Medicine |
| Subjects: | |
| Online Access: | http://www.wjtcm.org:8080/ch/reader/create_pdf.aspx?file_no=20160009&year_id=2016&quarter_id=1&flag=1 |
| _version_ | 1828832307704758272 |
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| author | Hong-Li Ma Jing-Shu Gao Feng Tian Ernest HY Ng Xiao-Ke Wu Jian-Ping Liu |
| author_facet | Hong-Li Ma Jing-Shu Gao Feng Tian Ernest HY Ng Xiao-Ke Wu Jian-Ping Liu |
| author_sort | Hong-Li Ma |
| collection | DOAJ |
| description | Introduction: Letrozole showed higher ovulation and live birth rates than clomiphene in infertile women with polycystic ovary syndrome (PCOS). Berberine, a major active component of Chinese herbal medicine rhizomacoptidis, has been used to improve insulin resistance to facilitate ovulation induction in women with PCOS, but there is no study reporting the live birth or its potential as a complementary treatment to letrozole. We aim to determine the efficacy of letrozole with or without berberine in achieving live births among 644 infertile women with PCOS in Mainland China. |
| first_indexed | 2024-12-12T16:51:34Z |
| format | Article |
| id | doaj.art-2dabfac59fd74c1fbd273d9b3041cdfc |
| institution | Directory Open Access Journal |
| issn | 2311-8571 |
| language | English |
| last_indexed | 2024-12-12T16:51:34Z |
| publishDate | 2016-11-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | World Journal of Traditional Chinese Medicine |
| spelling | doaj.art-2dabfac59fd74c1fbd273d9b3041cdfc2022-12-22T00:18:22ZengWolters Kluwer Medknow PublicationsWorld Journal of Traditional Chinese Medicine2311-85712016-11-0123364210.15806/j.issn.2311-8571.2016.00092016.0009Effect of Letrozole, Berberine, or Their Combination for Infertility in Women with Polycystic Ovary Syndrome: Statistical Analysis Plan for a Multicenter Randomized Controlled TrialHong-Li Ma0Jing-Shu Gao1Feng Tian2Ernest HY Ng3Xiao-Ke Wu4Jian-Ping Liu5Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, ChinaDepartment of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaInstitute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, ChinaDepartment of Obstetrics and Gynaecology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong KongDepartment of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaCentre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, ChinaIntroduction: Letrozole showed higher ovulation and live birth rates than clomiphene in infertile women with polycystic ovary syndrome (PCOS). Berberine, a major active component of Chinese herbal medicine rhizomacoptidis, has been used to improve insulin resistance to facilitate ovulation induction in women with PCOS, but there is no study reporting the live birth or its potential as a complementary treatment to letrozole. We aim to determine the efficacy of letrozole with or without berberine in achieving live births among 644 infertile women with PCOS in Mainland China.http://www.wjtcm.org:8080/ch/reader/create_pdf.aspx?file_no=20160009&year_id=2016&quarter_id=1&flag=1Polycystic ovary syndromeStatistical analysis planRandomized controlled trialLetrozoleBerberine |
| spellingShingle | Hong-Li Ma Jing-Shu Gao Feng Tian Ernest HY Ng Xiao-Ke Wu Jian-Ping Liu Effect of Letrozole, Berberine, or Their Combination for Infertility in Women with Polycystic Ovary Syndrome: Statistical Analysis Plan for a Multicenter Randomized Controlled Trial World Journal of Traditional Chinese Medicine Polycystic ovary syndrome Statistical analysis plan Randomized controlled trial Letrozole Berberine |
| title | Effect of Letrozole, Berberine, or Their Combination for Infertility in Women with Polycystic Ovary Syndrome: Statistical Analysis Plan for a Multicenter Randomized Controlled Trial |
| title_full | Effect of Letrozole, Berberine, or Their Combination for Infertility in Women with Polycystic Ovary Syndrome: Statistical Analysis Plan for a Multicenter Randomized Controlled Trial |
| title_fullStr | Effect of Letrozole, Berberine, or Their Combination for Infertility in Women with Polycystic Ovary Syndrome: Statistical Analysis Plan for a Multicenter Randomized Controlled Trial |
| title_full_unstemmed | Effect of Letrozole, Berberine, or Their Combination for Infertility in Women with Polycystic Ovary Syndrome: Statistical Analysis Plan for a Multicenter Randomized Controlled Trial |
| title_short | Effect of Letrozole, Berberine, or Their Combination for Infertility in Women with Polycystic Ovary Syndrome: Statistical Analysis Plan for a Multicenter Randomized Controlled Trial |
| title_sort | effect of letrozole berberine or their combination for infertility in women with polycystic ovary syndrome statistical analysis plan for a multicenter randomized controlled trial |
| topic | Polycystic ovary syndrome Statistical analysis plan Randomized controlled trial Letrozole Berberine |
| url | http://www.wjtcm.org:8080/ch/reader/create_pdf.aspx?file_no=20160009&year_id=2016&quarter_id=1&flag=1 |
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