Spatiotemporal Distribution of PRRSV-1 Clades in Hungary with a Focus on the Era of Disease Eradication
Porcine reproductive and respiratory syndrome (PRRS) is the cause of the most severe economic losses in the pig industry worldwide. PRRSV is extremely diverse in Europe, which poses a significant challenge to disease control within a country or any region. With the combination of phylogenetic recons...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/14/1/175 |
| _version_ | 1797359122703712256 |
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| author | Ádám Bálint Szilvia Jakab Eszter Kaszab Szilvia Marton Krisztián Bányai Sándor Kecskeméti István Szabó |
| author_facet | Ádám Bálint Szilvia Jakab Eszter Kaszab Szilvia Marton Krisztián Bányai Sándor Kecskeméti István Szabó |
| author_sort | Ádám Bálint |
| collection | DOAJ |
| description | Porcine reproductive and respiratory syndrome (PRRS) is the cause of the most severe economic losses in the pig industry worldwide. PRRSV is extremely diverse in Europe, which poses a significant challenge to disease control within a country or any region. With the combination of phylogenetic reconstruction and network analysis, we aimed to uncover the major routes of the dispersal of PRRSV clades within Hungary. In brief, by analyzing >2600 ORF5 sequences, we identified at least 12 clades (including 6 clades within lineage 1 and 3 clades within lineage 3) common in parts of Western Europe (including Denmark, Germany and the Netherlands) and identified 2 novel clades (designated X1 and X2). Of interest, some genetic clades unique to other central European countries, such as the Czech Republic and Poland, were not identified. The pattern of PRRSV clade distribution is consistent with the route of the pig trade among countries, showing that most of the identified clades were introduced from Western Europe when fatteners were transported to Hungary. As a result of rigorous implementation of the national eradication program, the swine population was declared officially free from PRRSV. This map of viral diversity and clade distribution will serve as valuable baseline information for the maintenance of PRRSV-free status in the post-eradication era. |
| first_indexed | 2024-03-08T15:12:08Z |
| format | Article |
| id | doaj.art-2dad46b9896d44fa8568d7093e0938bc |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-08T15:12:08Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-2dad46b9896d44fa8568d7093e0938bc2024-01-10T14:50:34ZengMDPI AGAnimals2076-26152024-01-0114117510.3390/ani14010175Spatiotemporal Distribution of PRRSV-1 Clades in Hungary with a Focus on the Era of Disease EradicationÁdám Bálint0Szilvia Jakab1Eszter Kaszab2Szilvia Marton3Krisztián Bányai4Sándor Kecskeméti5István Szabó6Veterinary Diagnostic Directorate, National Food Chain Safety Office, H-1143 Budapest, HungaryNational Laboratory for Infectious Animal Diseases, Antimicrobial Resistance, Veterinary Public Health and Food Chain Safety, H-1143 Budapest, HungaryNational Laboratory for Infectious Animal Diseases, Antimicrobial Resistance, Veterinary Public Health and Food Chain Safety, H-1143 Budapest, HungaryNational Laboratory for Infectious Animal Diseases, Antimicrobial Resistance, Veterinary Public Health and Food Chain Safety, H-1143 Budapest, HungaryNational Laboratory for Infectious Animal Diseases, Antimicrobial Resistance, Veterinary Public Health and Food Chain Safety, H-1143 Budapest, HungaryVeterinary Diagnostic Directorate, National Food Chain Safety Office, H-1143 Budapest, HungaryNational PRRS Eradication Committee, H-1024 Budapest, HungaryPorcine reproductive and respiratory syndrome (PRRS) is the cause of the most severe economic losses in the pig industry worldwide. PRRSV is extremely diverse in Europe, which poses a significant challenge to disease control within a country or any region. With the combination of phylogenetic reconstruction and network analysis, we aimed to uncover the major routes of the dispersal of PRRSV clades within Hungary. In brief, by analyzing >2600 ORF5 sequences, we identified at least 12 clades (including 6 clades within lineage 1 and 3 clades within lineage 3) common in parts of Western Europe (including Denmark, Germany and the Netherlands) and identified 2 novel clades (designated X1 and X2). Of interest, some genetic clades unique to other central European countries, such as the Czech Republic and Poland, were not identified. The pattern of PRRSV clade distribution is consistent with the route of the pig trade among countries, showing that most of the identified clades were introduced from Western Europe when fatteners were transported to Hungary. As a result of rigorous implementation of the national eradication program, the swine population was declared officially free from PRRSV. This map of viral diversity and clade distribution will serve as valuable baseline information for the maintenance of PRRSV-free status in the post-eradication era.https://www.mdpi.com/2076-2615/14/1/175porcine reproductive and respiratory syndromedisease eradicationphylogenygenetic diversitymolecular epidemiologyPRRS |
| spellingShingle | Ádám Bálint Szilvia Jakab Eszter Kaszab Szilvia Marton Krisztián Bányai Sándor Kecskeméti István Szabó Spatiotemporal Distribution of PRRSV-1 Clades in Hungary with a Focus on the Era of Disease Eradication Animals porcine reproductive and respiratory syndrome disease eradication phylogeny genetic diversity molecular epidemiology PRRS |
| title | Spatiotemporal Distribution of PRRSV-1 Clades in Hungary with a Focus on the Era of Disease Eradication |
| title_full | Spatiotemporal Distribution of PRRSV-1 Clades in Hungary with a Focus on the Era of Disease Eradication |
| title_fullStr | Spatiotemporal Distribution of PRRSV-1 Clades in Hungary with a Focus on the Era of Disease Eradication |
| title_full_unstemmed | Spatiotemporal Distribution of PRRSV-1 Clades in Hungary with a Focus on the Era of Disease Eradication |
| title_short | Spatiotemporal Distribution of PRRSV-1 Clades in Hungary with a Focus on the Era of Disease Eradication |
| title_sort | spatiotemporal distribution of prrsv 1 clades in hungary with a focus on the era of disease eradication |
| topic | porcine reproductive and respiratory syndrome disease eradication phylogeny genetic diversity molecular epidemiology PRRS |
| url | https://www.mdpi.com/2076-2615/14/1/175 |
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