Involvement of apoptosis in host-parasite interactions in the zebra mussel.
The question of whether cell death by apoptosis plays a biological function during infection is key to understanding host-parasite interactions. We investigated the involvement of apoptosis in several host-parasite systems, using zebra mussels Dreissena polymorpha as test organisms and their micro-...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23785455/?tool=EBI |
| _version_ | 1818405392013590528 |
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| author | Laëtitia Minguez Nelly Brulé Bénédicte Sohm Simon Devin Laure Giambérini |
| author_facet | Laëtitia Minguez Nelly Brulé Bénédicte Sohm Simon Devin Laure Giambérini |
| author_sort | Laëtitia Minguez |
| collection | DOAJ |
| description | The question of whether cell death by apoptosis plays a biological function during infection is key to understanding host-parasite interactions. We investigated the involvement of apoptosis in several host-parasite systems, using zebra mussels Dreissena polymorpha as test organisms and their micro- and macroparasites. As a stress response associated with parasitism, heat shock proteins (Hsp) can be induced. In this protein family, Hsp70 are known to be apoptosis inhibitors. Mussels were diagnosed for their respective infections by standard histological methods; apoptosis was detected using the TUNEL methods on paraffin sections and Hsp70 by immunohistochemistry on cryosections. Circulating hemocytes were the main cells observed in apoptosis whereas infected tissues displayed no or few apoptotic cells. Parasitism by intracellular bacteria Rickettsiales-like and the trematode Bucephalus polymorphus were associated with the inhibition of apoptosis whereas ciliates Ophryoglena spp. or the trematode Phyllodistomum folium did not involve significant differences in apoptosis. Even if some parasites were able to modulate apoptosis in zebra mussels, we did not see evidence of any involvement of Hsp70 on this mechanism. |
| first_indexed | 2024-12-14T08:55:19Z |
| format | Article |
| id | doaj.art-2daee94bbbcf436cbe25e6fc555b4db8 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T08:55:19Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-2daee94bbbcf436cbe25e6fc555b4db82022-12-21T23:08:57ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0186e6582210.1371/journal.pone.0065822Involvement of apoptosis in host-parasite interactions in the zebra mussel.Laëtitia MinguezNelly BruléBénédicte SohmSimon DevinLaure GiambériniThe question of whether cell death by apoptosis plays a biological function during infection is key to understanding host-parasite interactions. We investigated the involvement of apoptosis in several host-parasite systems, using zebra mussels Dreissena polymorpha as test organisms and their micro- and macroparasites. As a stress response associated with parasitism, heat shock proteins (Hsp) can be induced. In this protein family, Hsp70 are known to be apoptosis inhibitors. Mussels were diagnosed for their respective infections by standard histological methods; apoptosis was detected using the TUNEL methods on paraffin sections and Hsp70 by immunohistochemistry on cryosections. Circulating hemocytes were the main cells observed in apoptosis whereas infected tissues displayed no or few apoptotic cells. Parasitism by intracellular bacteria Rickettsiales-like and the trematode Bucephalus polymorphus were associated with the inhibition of apoptosis whereas ciliates Ophryoglena spp. or the trematode Phyllodistomum folium did not involve significant differences in apoptosis. Even if some parasites were able to modulate apoptosis in zebra mussels, we did not see evidence of any involvement of Hsp70 on this mechanism.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23785455/?tool=EBI |
| spellingShingle | Laëtitia Minguez Nelly Brulé Bénédicte Sohm Simon Devin Laure Giambérini Involvement of apoptosis in host-parasite interactions in the zebra mussel. PLoS ONE |
| title | Involvement of apoptosis in host-parasite interactions in the zebra mussel. |
| title_full | Involvement of apoptosis in host-parasite interactions in the zebra mussel. |
| title_fullStr | Involvement of apoptosis in host-parasite interactions in the zebra mussel. |
| title_full_unstemmed | Involvement of apoptosis in host-parasite interactions in the zebra mussel. |
| title_short | Involvement of apoptosis in host-parasite interactions in the zebra mussel. |
| title_sort | involvement of apoptosis in host parasite interactions in the zebra mussel |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23785455/?tool=EBI |
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