Expression of EGF, EGFR, and proliferation in placentas from pregnancies complicated with preeclampsia
Objective: To investigate proliferation, EGF and EGFR expression of villous trophoblast (VTB), decidual cells (DC), and extravillous trophoblast (EVTB) in the placentas from pregnancies complicated with preeclampsia (PE) and to compare them with placentas from normal pregnancies. Methods: Twenty-nin...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2017-01-01
|
| Series: | Hypertension in Pregnancy |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641955.2016.1218502 |
| _version_ | 1811153887663489024 |
|---|---|
| author | Indira Kosovic Ivana Kuzmic Prusac Anna Berkovic Jelena Marusic Marko Mimica Sandra Zekic Tomas |
| author_facet | Indira Kosovic Ivana Kuzmic Prusac Anna Berkovic Jelena Marusic Marko Mimica Sandra Zekic Tomas |
| author_sort | Indira Kosovic |
| collection | DOAJ |
| description | Objective: To investigate proliferation, EGF and EGFR expression of villous trophoblast (VTB), decidual cells (DC), and extravillous trophoblast (EVTB) in the placentas from pregnancies complicated with preeclampsia (PE) and to compare them with placentas from normal pregnancies. Methods: Twenty-nine PE placentas and 19 control placentas were studied for EGF and EGFR immunohistochemical expression (noted as week, moderate or strong). Proliferation was expressed as the proliferation index. The CK7 antibody was used to distinguish DC from EVTB. Results: DC and EVTB proliferation was significantly higher in PE placentas. EGFR and EGF expression showed no significant difference. Conclusion: Higher DC and EVTB proliferation in PE could contribute to PE development. |
| first_indexed | 2024-03-11T23:46:49Z |
| format | Article |
| id | doaj.art-2daf08dc274d443ea84253b5a5776a1b |
| institution | Directory Open Access Journal |
| issn | 1064-1955 1525-6065 |
| language | English |
| last_indexed | 2024-03-11T23:46:49Z |
| publishDate | 2017-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hypertension in Pregnancy |
| spelling | doaj.art-2daf08dc274d443ea84253b5a5776a1b2023-09-19T09:24:41ZengTaylor & Francis GroupHypertension in Pregnancy1064-19551525-60652017-01-01361162010.1080/10641955.2016.12185021218502Expression of EGF, EGFR, and proliferation in placentas from pregnancies complicated with preeclampsiaIndira Kosovic0Ivana Kuzmic Prusac1Anna Berkovic2Jelena Marusic3Marko Mimica4Sandra Zekic Tomas5Split University Hospital CenterSplit University Hospital CenterUniversity of SplitSplit University Hospital CenterSplit University Hospital CenterSplit University Hospital CenterObjective: To investigate proliferation, EGF and EGFR expression of villous trophoblast (VTB), decidual cells (DC), and extravillous trophoblast (EVTB) in the placentas from pregnancies complicated with preeclampsia (PE) and to compare them with placentas from normal pregnancies. Methods: Twenty-nine PE placentas and 19 control placentas were studied for EGF and EGFR immunohistochemical expression (noted as week, moderate or strong). Proliferation was expressed as the proliferation index. The CK7 antibody was used to distinguish DC from EVTB. Results: DC and EVTB proliferation was significantly higher in PE placentas. EGFR and EGF expression showed no significant difference. Conclusion: Higher DC and EVTB proliferation in PE could contribute to PE development.http://dx.doi.org/10.1080/10641955.2016.1218502preeclampsiadecidual cellsextravillous trophoblastegfegfrproliferation |
| spellingShingle | Indira Kosovic Ivana Kuzmic Prusac Anna Berkovic Jelena Marusic Marko Mimica Sandra Zekic Tomas Expression of EGF, EGFR, and proliferation in placentas from pregnancies complicated with preeclampsia Hypertension in Pregnancy preeclampsia decidual cells extravillous trophoblast egf egfr proliferation |
| title | Expression of EGF, EGFR, and proliferation in placentas from pregnancies complicated with preeclampsia |
| title_full | Expression of EGF, EGFR, and proliferation in placentas from pregnancies complicated with preeclampsia |
| title_fullStr | Expression of EGF, EGFR, and proliferation in placentas from pregnancies complicated with preeclampsia |
| title_full_unstemmed | Expression of EGF, EGFR, and proliferation in placentas from pregnancies complicated with preeclampsia |
| title_short | Expression of EGF, EGFR, and proliferation in placentas from pregnancies complicated with preeclampsia |
| title_sort | expression of egf egfr and proliferation in placentas from pregnancies complicated with preeclampsia |
| topic | preeclampsia decidual cells extravillous trophoblast egf egfr proliferation |
| url | http://dx.doi.org/10.1080/10641955.2016.1218502 |
| work_keys_str_mv | AT indirakosovic expressionofegfegfrandproliferationinplacentasfrompregnanciescomplicatedwithpreeclampsia AT ivanakuzmicprusac expressionofegfegfrandproliferationinplacentasfrompregnanciescomplicatedwithpreeclampsia AT annaberkovic expressionofegfegfrandproliferationinplacentasfrompregnanciescomplicatedwithpreeclampsia AT jelenamarusic expressionofegfegfrandproliferationinplacentasfrompregnanciescomplicatedwithpreeclampsia AT markomimica expressionofegfegfrandproliferationinplacentasfrompregnanciescomplicatedwithpreeclampsia AT sandrazekictomas expressionofegfegfrandproliferationinplacentasfrompregnanciescomplicatedwithpreeclampsia |