Subcutaneous platelet rich plasma therapy for management of hyperalgesia in complex regional pain syndrome
Objectives: Complex regional pain syndrome (CRPS), which usually develops after a traumatic event, often has a debilitating effect on the quality of life. Treatment is multidisciplinary and is based primarily on pain relief. Due to the symptoms of hyperalgesia and allodynia in patients with CRPS, de...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Indian Journal of Pain |
| Subjects: | |
| Online Access: | http://www.indianjpain.org/article.asp?issn=0970-5333;year=2023;volume=37;issue=2;spage=106;epage=109;aulast=Rout |
| _version_ | 1797738713749389312 |
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| author | Aradhana Rout Kamparsh Thakur Amit Kumar Choubey |
| author_facet | Aradhana Rout Kamparsh Thakur Amit Kumar Choubey |
| author_sort | Aradhana Rout |
| collection | DOAJ |
| description | Objectives: Complex regional pain syndrome (CRPS), which usually develops after a traumatic event, often has a debilitating effect on the quality of life. Treatment is multidisciplinary and is based primarily on pain relief. Due to the symptoms of hyperalgesia and allodynia in patients with CRPS, dermatology opinion is often seeked. CRPS is a difficult disorder to treat and platelet-rich plasma (PRP) is a potential treatment modality for pain relief in this debilitating illness. We aimed to investigate the role of subcutaneous PRP for relief of hyperalgesia in patients with CRPS. Materials and Methods: A comparative prospective study of 15 male patients with CRPS diagnosed clinically by the Budapest criteria and radiologically by magnetic resonance imaging was enrolled for the study. PRP was injected subcutaneously at biweekly interval for 8 weeks and the results were assessed clinically by neuropathic pain score (NPS) score. The patient satisfaction was noted at baseline, 4 weeks, and 8 weeks. Patients were followed up for 3 months to assess the increase or decrease in hyperalgesia after stopping PRP. ANOVA was used with the Bonferroni correction for NPS score at various time interval. P ≤ 0.05 is considered statistically significant. Results: Numeric Rating Scale score showed statistically significant improvement at end of the study as compared to the baseline. Patients also had improvement in range of motion which was assessed at every visit. A few patients had mild redness and burning postprocedure which resolved spontaneously after a few hours. Conclusions: From this study, we concluded that subcutaneous PRP shows a significant reduction of hyperalgesia associated with CRPS. |
| first_indexed | 2024-03-12T13:46:50Z |
| format | Article |
| id | doaj.art-2db26b93bd3d4c2cb9ca3aaad81e4cce |
| institution | Directory Open Access Journal |
| issn | 0970-5333 |
| language | English |
| last_indexed | 2024-03-12T13:46:50Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pain |
| spelling | doaj.art-2db26b93bd3d4c2cb9ca3aaad81e4cce2023-08-23T08:23:33ZengWolters Kluwer Medknow PublicationsIndian Journal of Pain0970-53332023-01-0137210610910.4103/ijpn.ijpn_93_22Subcutaneous platelet rich plasma therapy for management of hyperalgesia in complex regional pain syndromeAradhana RoutKamparsh ThakurAmit Kumar ChoubeyObjectives: Complex regional pain syndrome (CRPS), which usually develops after a traumatic event, often has a debilitating effect on the quality of life. Treatment is multidisciplinary and is based primarily on pain relief. Due to the symptoms of hyperalgesia and allodynia in patients with CRPS, dermatology opinion is often seeked. CRPS is a difficult disorder to treat and platelet-rich plasma (PRP) is a potential treatment modality for pain relief in this debilitating illness. We aimed to investigate the role of subcutaneous PRP for relief of hyperalgesia in patients with CRPS. Materials and Methods: A comparative prospective study of 15 male patients with CRPS diagnosed clinically by the Budapest criteria and radiologically by magnetic resonance imaging was enrolled for the study. PRP was injected subcutaneously at biweekly interval for 8 weeks and the results were assessed clinically by neuropathic pain score (NPS) score. The patient satisfaction was noted at baseline, 4 weeks, and 8 weeks. Patients were followed up for 3 months to assess the increase or decrease in hyperalgesia after stopping PRP. ANOVA was used with the Bonferroni correction for NPS score at various time interval. P ≤ 0.05 is considered statistically significant. Results: Numeric Rating Scale score showed statistically significant improvement at end of the study as compared to the baseline. Patients also had improvement in range of motion which was assessed at every visit. A few patients had mild redness and burning postprocedure which resolved spontaneously after a few hours. Conclusions: From this study, we concluded that subcutaneous PRP shows a significant reduction of hyperalgesia associated with CRPS.http://www.indianjpain.org/article.asp?issn=0970-5333;year=2023;volume=37;issue=2;spage=106;epage=109;aulast=Routcomplex regional pain syndromehyperalgesiaplatelet-rich plasma |
| spellingShingle | Aradhana Rout Kamparsh Thakur Amit Kumar Choubey Subcutaneous platelet rich plasma therapy for management of hyperalgesia in complex regional pain syndrome Indian Journal of Pain complex regional pain syndrome hyperalgesia platelet-rich plasma |
| title | Subcutaneous platelet rich plasma therapy for management of hyperalgesia in complex regional pain syndrome |
| title_full | Subcutaneous platelet rich plasma therapy for management of hyperalgesia in complex regional pain syndrome |
| title_fullStr | Subcutaneous platelet rich plasma therapy for management of hyperalgesia in complex regional pain syndrome |
| title_full_unstemmed | Subcutaneous platelet rich plasma therapy for management of hyperalgesia in complex regional pain syndrome |
| title_short | Subcutaneous platelet rich plasma therapy for management of hyperalgesia in complex regional pain syndrome |
| title_sort | subcutaneous platelet rich plasma therapy for management of hyperalgesia in complex regional pain syndrome |
| topic | complex regional pain syndrome hyperalgesia platelet-rich plasma |
| url | http://www.indianjpain.org/article.asp?issn=0970-5333;year=2023;volume=37;issue=2;spage=106;epage=109;aulast=Rout |
| work_keys_str_mv | AT aradhanarout subcutaneousplateletrichplasmatherapyformanagementofhyperalgesiaincomplexregionalpainsyndrome AT kamparshthakur subcutaneousplateletrichplasmatherapyformanagementofhyperalgesiaincomplexregionalpainsyndrome AT amitkumarchoubey subcutaneousplateletrichplasmatherapyformanagementofhyperalgesiaincomplexregionalpainsyndrome |