A rare extramedullary involvement in myeloma: lung parenchyma and association with unfavorable chromosomal abnormalities
Although pulmonary complications developing secondary to lung infections and involvement in ribs occur frequently in multiple myeloma (MM), involvement of the lung parenchyma is quite rare. In clinical studies, the involvement of lung parenchyma has been found to be associated with unfavorable progn...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2010-06-01
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| Series: | Turkish Journal of Hematology |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-30306 |
| _version_ | 1797916900235149312 |
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| author | Özlem Şahin Balçık Murat Albayrak Simten Dağdaş Funda Ceran Gülsüm Özet Funda Demirağ Osman Yokuş |
| author_facet | Özlem Şahin Balçık Murat Albayrak Simten Dağdaş Funda Ceran Gülsüm Özet Funda Demirağ Osman Yokuş |
| author_sort | Özlem Şahin Balçık |
| collection | DOAJ |
| description | Although pulmonary complications developing secondary to lung infections and involvement in ribs occur frequently in multiple myeloma (MM), involvement of the lung parenchyma is quite rare. In clinical studies, the involvement of lung parenchyma has been found to be associated with unfavorable prognosis. Here, a MM case in whom involvement of lung parenchyma was accompanied by unfavorable prognostic cytogenetic markers is presented.
A 62-year-old male presented with complaint of cough, and heterogeneous hypodense mass was detected in thorax computerized tomography. The patient underwent bronchoscopic biopsy. Pathological examination revealed diffuse plasma cell infiltration staining with kappa immunohistochemically. In bone marrow biopsy, plasma cell infiltration was observed. In conventional cytogenetic examination, hypodiploidy was established. In cytogenetic examination carried out with fluorescence in situ hybridization, deletion (13q) was determined. In conclusion, in patients diagnosed with MM and presenting with pulmonary mass lesion, lung involvement associated with plasma cell infiltration should also be considered in the differential diagnosis. As overall survival is low in these cases, more aggressive treatment approaches such as high-dose treatment should be immediately considered. |
| first_indexed | 2024-04-10T13:04:39Z |
| format | Article |
| id | doaj.art-2db2b8248bba49ef9dc7d333db26f0df |
| institution | Directory Open Access Journal |
| issn | 1308-5263 |
| language | English |
| last_indexed | 2024-04-10T13:04:39Z |
| publishDate | 2010-06-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkish Journal of Hematology |
| spelling | doaj.art-2db2b8248bba49ef9dc7d333db26f0df2023-02-15T16:13:00ZengGalenos Publishing HouseTurkish Journal of Hematology1308-52632010-06-0127210911210.5152/tjh.2010.08TJH-30306A rare extramedullary involvement in myeloma: lung parenchyma and association with unfavorable chromosomal abnormalitiesÖzlem Şahin Balçık0Murat Albayrak1Simten Dağdaş2Funda Ceran3Gülsüm Özet4Funda Demirağ5Osman Yokuş6Department Of Hematology, Oncology Education And Research Hospital, Ankara, TurkeyDepartment Of Hematology, Oncology Education And Research Hospital, Ankara, TurkeyDepartment Of Hematology, Numune Education And Research Hospital, Ankara, TurkeyDepartment Of Hematology, Numune Education And Research Hospital, Ankara, TurkeyDepartment Of Hematology, Numune Education And Research Hospital, Ankara, TurkeyDepartment Of Pathology, Atatürk Chest Diseases And Chest Surgery Education And Research Hospital, Ankara, TurkeyDepartment Of Hematology, Kayseri Education And Research Hospital, Kayseri, TurkeyAlthough pulmonary complications developing secondary to lung infections and involvement in ribs occur frequently in multiple myeloma (MM), involvement of the lung parenchyma is quite rare. In clinical studies, the involvement of lung parenchyma has been found to be associated with unfavorable prognosis. Here, a MM case in whom involvement of lung parenchyma was accompanied by unfavorable prognostic cytogenetic markers is presented. A 62-year-old male presented with complaint of cough, and heterogeneous hypodense mass was detected in thorax computerized tomography. The patient underwent bronchoscopic biopsy. Pathological examination revealed diffuse plasma cell infiltration staining with kappa immunohistochemically. In bone marrow biopsy, plasma cell infiltration was observed. In conventional cytogenetic examination, hypodiploidy was established. In cytogenetic examination carried out with fluorescence in situ hybridization, deletion (13q) was determined. In conclusion, in patients diagnosed with MM and presenting with pulmonary mass lesion, lung involvement associated with plasma cell infiltration should also be considered in the differential diagnosis. As overall survival is low in these cases, more aggressive treatment approaches such as high-dose treatment should be immediately considered.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-30306myelomapulmonary involvementprognosticationcytogeneticsmolecular geneticsdel(13q)hypodiploidy |
| spellingShingle | Özlem Şahin Balçık Murat Albayrak Simten Dağdaş Funda Ceran Gülsüm Özet Funda Demirağ Osman Yokuş A rare extramedullary involvement in myeloma: lung parenchyma and association with unfavorable chromosomal abnormalities Turkish Journal of Hematology myeloma pulmonary involvement prognostication cytogenetics molecular genetics del(13q) hypodiploidy |
| title | A rare extramedullary involvement in myeloma: lung parenchyma and association with unfavorable chromosomal abnormalities |
| title_full | A rare extramedullary involvement in myeloma: lung parenchyma and association with unfavorable chromosomal abnormalities |
| title_fullStr | A rare extramedullary involvement in myeloma: lung parenchyma and association with unfavorable chromosomal abnormalities |
| title_full_unstemmed | A rare extramedullary involvement in myeloma: lung parenchyma and association with unfavorable chromosomal abnormalities |
| title_short | A rare extramedullary involvement in myeloma: lung parenchyma and association with unfavorable chromosomal abnormalities |
| title_sort | rare extramedullary involvement in myeloma lung parenchyma and association with unfavorable chromosomal abnormalities |
| topic | myeloma pulmonary involvement prognostication cytogenetics molecular genetics del(13q) hypodiploidy |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-30306 |
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