Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia
Objective To evaluate the association between objective short sleep duration in patients with insomnia and changes in blood parameters related to hypothalamic-pituitary-adrenal (HPA) axis activity.Method A cross-sectional pilot study was conducted in 30 middle-aged adults with chronic insomnia who w...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Neurologia (ABNEURO)
2015-06-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000600516&lng=en&tlng=en |
| _version_ | 1818250257044078592 |
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| author | Carolina D’Aurea Dalva Poyares Ronaldo D. Piovezan Gisele Passos Sergio Tufik Marco Tulio de Mello |
| author_facet | Carolina D’Aurea Dalva Poyares Ronaldo D. Piovezan Gisele Passos Sergio Tufik Marco Tulio de Mello |
| author_sort | Carolina D’Aurea |
| collection | DOAJ |
| description | Objective To evaluate the association between objective short sleep duration in patients with insomnia and changes in blood parameters related to hypothalamic-pituitary-adrenal (HPA) axis activity.Method A cross-sectional pilot study was conducted in 30 middle-aged adults with chronic insomnia who were divided into 2 groups according to polysomnography (PSG) total sleep time (TST) (TST > 5h and < 5h). All patients underwent subjective analysis of sleep quality, anthropometric measurements, PSG, and determination off asting blood parameters.Results The results revealed lower sleep efficiency and higher sleep latency for those with a TST < 5h. The subjective sleep quality was worse in the TST < 5h. Significantly, higher glucose and cortisol levels were observed with a TST < 5h. Glucose, cortisol and ACTH levels were inversely correlated with the PSG total sleep time.Conclusion Patients with insomnia with objective short sleep duration had HPA-associated endocrine and metabolic imbalances chronically linked to increases in cardiovascular risk observed with this more severe insomnia phenotype. |
| first_indexed | 2024-12-12T15:49:30Z |
| format | Article |
| id | doaj.art-2db3d6fc8b0c42d886da4d2302a05c75 |
| institution | Directory Open Access Journal |
| issn | 1678-4227 |
| language | English |
| last_indexed | 2024-12-12T15:49:30Z |
| publishDate | 2015-06-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-2db3d6fc8b0c42d886da4d2302a05c752022-12-22T00:19:40ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-42272015-06-0173651651910.1590/0004-282X20150053S0004-282X2015000600516Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomniaCarolina D’AureaDalva PoyaresRonaldo D. PiovezanGisele PassosSergio TufikMarco Tulio de MelloObjective To evaluate the association between objective short sleep duration in patients with insomnia and changes in blood parameters related to hypothalamic-pituitary-adrenal (HPA) axis activity.Method A cross-sectional pilot study was conducted in 30 middle-aged adults with chronic insomnia who were divided into 2 groups according to polysomnography (PSG) total sleep time (TST) (TST > 5h and < 5h). All patients underwent subjective analysis of sleep quality, anthropometric measurements, PSG, and determination off asting blood parameters.Results The results revealed lower sleep efficiency and higher sleep latency for those with a TST < 5h. The subjective sleep quality was worse in the TST < 5h. Significantly, higher glucose and cortisol levels were observed with a TST < 5h. Glucose, cortisol and ACTH levels were inversely correlated with the PSG total sleep time.Conclusion Patients with insomnia with objective short sleep duration had HPA-associated endocrine and metabolic imbalances chronically linked to increases in cardiovascular risk observed with this more severe insomnia phenotype.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000600516&lng=en&tlng=entranstornos de insôniacurta duração objetiva de sonoeixo hipotálamo-pituitária-adrenal |
| spellingShingle | Carolina D’Aurea Dalva Poyares Ronaldo D. Piovezan Gisele Passos Sergio Tufik Marco Tulio de Mello Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia Arquivos de Neuro-Psiquiatria transtornos de insônia curta duração objetiva de sono eixo hipotálamo-pituitária-adrenal |
| title | Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia |
| title_full | Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia |
| title_fullStr | Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia |
| title_full_unstemmed | Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia |
| title_short | Objective short sleep duration is associated with the activity of the hypothalamic-pituitary-adrenal axis in insomnia |
| title_sort | objective short sleep duration is associated with the activity of the hypothalamic pituitary adrenal axis in insomnia |
| topic | transtornos de insônia curta duração objetiva de sono eixo hipotálamo-pituitária-adrenal |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000600516&lng=en&tlng=en |
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