Culture of mouse peritoneal macrophages with mouse serum induces lipid bodies that associate with the parasitophorous vacuole and decrease their microbicidal capacity against Toxoplasma gondii

Culture of mouse peritoneal macrophages with mouse serum induces lipid bodies that associate with the parasitophorous vacuole and decrease their microbicidal capacity against Toxoplasma gondii

Lipid bodies [lipid droplets (LBs)] are lipid-rich organelles involved in lipid metabolism, signalling and inflammation. Recent findings suggest a role for LBs in host response to infection; however, the potential functions of this organelle in Toxoplasma gondii infection and how it alters macrophag...

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Bibliographic Details
Main Authors: Laura Azeredo Miranda Mota, João Roberto Neto, Verônica Gomes Monteiro, Caroliny Samary Silva Lobato, Marco Antonio de Oliveira, Maura da Cunha, Heloisa D’Ávila, Sérgio Henrique Seabra, Patrícia Torres Bozza, Renato Augusto DaMatta
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2014-09-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
macrophages
lipid bodies
nitric oxide
prostaglandin
microbicidal capacity
Toxoplasma gondii
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000600767&lng=en&tlng=en

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