Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids.

Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids.

Distinct transcriptional states are maintained through organization of chromatin, resulting from the sum of numerous repressive and active histone modifications, into tightly packaged heterochromatin versus more accessible euchromatin. Polycomb repressive complex 2 (PRC2) is the main mammalian compl...

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Bibliographic Details
Main Authors: Ewa M Michalak, Michael J G Milevskiy, Rachel M Joyce, Johanna F Dekkers, Paul R Jamieson, Bhupinder Pal, Caleb A Dawson, Yifang Hu, Stuart H Orkin, Warren S Alexander, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-08-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC6095611?pdf=render

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