TMEM16A inhibits angiotensin II-induced basilar artery smooth muscle cell migration in a WNK1-dependent manner

TMEM16A inhibits angiotensin II-induced basilar artery smooth muscle cell migration in a WNK1-dependent manner

Vascular smooth muscle cell (VSMC) migration plays a critical role in the pathogenesis of many cardiovascular diseases. We recently showed that TMEM16A is involved in hypertension-induced cerebrovascular remodeling. However, it is unclear whether this effect is related to the regulation of VSMC migr...

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Bibliographic Details
Main Authors: Huaqing Zheng, Xiaolong Li, Xin Zeng, Chengcui Huang, Mingming Ma, Xiaofei Lv, Yajuan Zhang, Lu Sun, Guanlei Wang, Yanhua Du, Yongyuan Guan
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Acta Pharmaceutica Sinica B
Subjects:
TMEM16A
Integrin
RhoA/ROCK
VSMC migration
Vascular remodeling
WNK1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521001416

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