F-actin mechanics control spindle centring in the mouse zygote
How the mitotic spindle is positioned in the centre of the cell during the first mitotic division is not clear. Here Chaigne et al.show that the pronucleus coarsely centres using F-actin/Myosin-Vb dynamics, and the metaphase plate is finely centred by an F-actin cage influenced by high cortical tens...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-01-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms10253 |
| _version_ | 1818684327670579200 |
|---|---|
| author | Agathe Chaigne Clément Campillo Raphaël Voituriez Nir S. Gov Cécile Sykes Marie-Hélène Verlhac Marie-Emilie Terret |
| author_facet | Agathe Chaigne Clément Campillo Raphaël Voituriez Nir S. Gov Cécile Sykes Marie-Hélène Verlhac Marie-Emilie Terret |
| author_sort | Agathe Chaigne |
| collection | DOAJ |
| description | How the mitotic spindle is positioned in the centre of the cell during the first mitotic division is not clear. Here Chaigne et al.show that the pronucleus coarsely centres using F-actin/Myosin-Vb dynamics, and the metaphase plate is finely centred by an F-actin cage influenced by high cortical tension. |
| first_indexed | 2024-12-17T10:48:52Z |
| format | Article |
| id | doaj.art-2db63ef515514eb3964e8307e1af04d8 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:48:52Z |
| publishDate | 2016-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2db63ef515514eb3964e8307e1af04d82022-12-21T21:52:02ZengNature PortfolioNature Communications2041-17232016-01-017111410.1038/ncomms10253F-actin mechanics control spindle centring in the mouse zygoteAgathe Chaigne0Clément Campillo1Raphaël Voituriez2Nir S. Gov3Cécile Sykes4Marie-Hélène Verlhac5Marie-Emilie Terret6CIRB, Collège de France, and CNRS-UMR7241 and INSERM-U1050, Equipe labellisée Ligue contre le CancerUniversité Evry Val d’Essonne, LAMBE, Boulevard F MitterrandUMR7600-CNRS/UPMCDepartment of Chemical Physics, Weizmann Institute of ScienceCNRS-UMR168CIRB, Collège de France, and CNRS-UMR7241 and INSERM-U1050, Equipe labellisée Ligue contre le CancerCIRB, Collège de France, and CNRS-UMR7241 and INSERM-U1050, Equipe labellisée Ligue contre le CancerHow the mitotic spindle is positioned in the centre of the cell during the first mitotic division is not clear. Here Chaigne et al.show that the pronucleus coarsely centres using F-actin/Myosin-Vb dynamics, and the metaphase plate is finely centred by an F-actin cage influenced by high cortical tension.https://doi.org/10.1038/ncomms10253 |
| spellingShingle | Agathe Chaigne Clément Campillo Raphaël Voituriez Nir S. Gov Cécile Sykes Marie-Hélène Verlhac Marie-Emilie Terret F-actin mechanics control spindle centring in the mouse zygote Nature Communications |
| title | F-actin mechanics control spindle centring in the mouse zygote |
| title_full | F-actin mechanics control spindle centring in the mouse zygote |
| title_fullStr | F-actin mechanics control spindle centring in the mouse zygote |
| title_full_unstemmed | F-actin mechanics control spindle centring in the mouse zygote |
| title_short | F-actin mechanics control spindle centring in the mouse zygote |
| title_sort | f actin mechanics control spindle centring in the mouse zygote |
| url | https://doi.org/10.1038/ncomms10253 |
| work_keys_str_mv | AT agathechaigne factinmechanicscontrolspindlecentringinthemousezygote AT clementcampillo factinmechanicscontrolspindlecentringinthemousezygote AT raphaelvoituriez factinmechanicscontrolspindlecentringinthemousezygote AT nirsgov factinmechanicscontrolspindlecentringinthemousezygote AT cecilesykes factinmechanicscontrolspindlecentringinthemousezygote AT marieheleneverlhac factinmechanicscontrolspindlecentringinthemousezygote AT marieemilieterret factinmechanicscontrolspindlecentringinthemousezygote |