The Dependence of Renal <sup>68</sup>Ga[Ga]-DOTATOC Uptake on Kidney Function and Its Relevance for Peptide Receptor Radionuclide Therapy with <sup>177</sup>Lu[Lu]-DOTATOC
Background: In addition to its SSTR-specific binding in tumors and healthy tissues, DOTATOC analogues accumulate in kidney parenchyma. Renal tracer uptake might be a surrogate of kidney function or dysfunction. This study aimed to evaluate if kidney function can be estimated from <sup>68</s...
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MDPI AG
2021-07-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/7/1216 |
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| author | Falk Gühne Alexander Heinzig Philipp Seifert Robert Drescher Martin Freesmeyer |
| author_facet | Falk Gühne Alexander Heinzig Philipp Seifert Robert Drescher Martin Freesmeyer |
| author_sort | Falk Gühne |
| collection | DOAJ |
| description | Background: In addition to its SSTR-specific binding in tumors and healthy tissues, DOTATOC analogues accumulate in kidney parenchyma. Renal tracer uptake might be a surrogate of kidney function or dysfunction. This study aimed to evaluate if kidney function can be estimated from <sup>68</sup>Ga[Ga]-DOTATOC uptake in PET/CT and its impact on the nephrotoxicity of <sup>177</sup>Lu[Lu]-DOTATOC PRRT. Methods: Two cohorts of patients (A: 128 diagnostic patients; B: 32 PRRT patients) were evaluated retrospectively. SUV values of the kidneys, physiologically SSTR-expressing organs and in background compartments were assessed. Kidney function was calculated as eGFR by CKD-EPI creatinine equation. Pearson’s correlation coefficients and treatment-induced changes of uptake and kidney function were assessed and compared. Results: Kidney function and renal DOTATOC uptake showed a significant inverse correlation (R<sup>2</sup> = 0.037; <i>p</i> = 0.029). Evaluated models of PET/CT measurements were not able to predict kidney function sufficiently. The uptake of other organs did not depend on eGFR. While the renal uptake increased after PRRT (<i>p</i> < 0.001), the kidney function did not change significantly (<i>p</i> = 0.382). Neither low pre-therapeutic eGFR nor high pre-therapeutic kidney uptake were risk factors of PRRT-induced deterioration in kidney function. Conclusion: The relevance of kidney function for renal <sup>68</sup>Ga[Ga]-DOTATOC uptake is limited. The nephrotoxicity of <sup>177</sup>Lu[Lu]-DOTATOC PRRT might be low and cannot be reliably predicted by pre-therapeutic measurements. |
| first_indexed | 2024-03-10T09:41:53Z |
| format | Article |
| id | doaj.art-2db657ab2f2c4099b13e926dba2227e6 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T09:41:53Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
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| series | Diagnostics |
| spelling | doaj.art-2db657ab2f2c4099b13e926dba2227e62023-11-22T03:34:28ZengMDPI AGDiagnostics2075-44182021-07-01117121610.3390/diagnostics11071216The Dependence of Renal <sup>68</sup>Ga[Ga]-DOTATOC Uptake on Kidney Function and Its Relevance for Peptide Receptor Radionuclide Therapy with <sup>177</sup>Lu[Lu]-DOTATOCFalk Gühne0Alexander Heinzig1Philipp Seifert2Robert Drescher3Martin Freesmeyer4Clinic of Nuclear Medicine, Jena University Hospital, Am Klinikum 1, 07747 Jena, GermanyClinic of Nuclear Medicine, Jena University Hospital, Am Klinikum 1, 07747 Jena, GermanyClinic of Nuclear Medicine, Jena University Hospital, Am Klinikum 1, 07747 Jena, GermanyClinic of Nuclear Medicine, Jena University Hospital, Am Klinikum 1, 07747 Jena, GermanyClinic of Nuclear Medicine, Jena University Hospital, Am Klinikum 1, 07747 Jena, GermanyBackground: In addition to its SSTR-specific binding in tumors and healthy tissues, DOTATOC analogues accumulate in kidney parenchyma. Renal tracer uptake might be a surrogate of kidney function or dysfunction. This study aimed to evaluate if kidney function can be estimated from <sup>68</sup>Ga[Ga]-DOTATOC uptake in PET/CT and its impact on the nephrotoxicity of <sup>177</sup>Lu[Lu]-DOTATOC PRRT. Methods: Two cohorts of patients (A: 128 diagnostic patients; B: 32 PRRT patients) were evaluated retrospectively. SUV values of the kidneys, physiologically SSTR-expressing organs and in background compartments were assessed. Kidney function was calculated as eGFR by CKD-EPI creatinine equation. Pearson’s correlation coefficients and treatment-induced changes of uptake and kidney function were assessed and compared. Results: Kidney function and renal DOTATOC uptake showed a significant inverse correlation (R<sup>2</sup> = 0.037; <i>p</i> = 0.029). Evaluated models of PET/CT measurements were not able to predict kidney function sufficiently. The uptake of other organs did not depend on eGFR. While the renal uptake increased after PRRT (<i>p</i> < 0.001), the kidney function did not change significantly (<i>p</i> = 0.382). Neither low pre-therapeutic eGFR nor high pre-therapeutic kidney uptake were risk factors of PRRT-induced deterioration in kidney function. Conclusion: The relevance of kidney function for renal <sup>68</sup>Ga[Ga]-DOTATOC uptake is limited. The nephrotoxicity of <sup>177</sup>Lu[Lu]-DOTATOC PRRT might be low and cannot be reliably predicted by pre-therapeutic measurements.https://www.mdpi.com/2075-4418/11/7/1216DOTATOCPET/CTPRRTkidney function |
| spellingShingle | Falk Gühne Alexander Heinzig Philipp Seifert Robert Drescher Martin Freesmeyer The Dependence of Renal <sup>68</sup>Ga[Ga]-DOTATOC Uptake on Kidney Function and Its Relevance for Peptide Receptor Radionuclide Therapy with <sup>177</sup>Lu[Lu]-DOTATOC Diagnostics DOTATOC PET/CT PRRT kidney function |
| title | The Dependence of Renal <sup>68</sup>Ga[Ga]-DOTATOC Uptake on Kidney Function and Its Relevance for Peptide Receptor Radionuclide Therapy with <sup>177</sup>Lu[Lu]-DOTATOC |
| title_full | The Dependence of Renal <sup>68</sup>Ga[Ga]-DOTATOC Uptake on Kidney Function and Its Relevance for Peptide Receptor Radionuclide Therapy with <sup>177</sup>Lu[Lu]-DOTATOC |
| title_fullStr | The Dependence of Renal <sup>68</sup>Ga[Ga]-DOTATOC Uptake on Kidney Function and Its Relevance for Peptide Receptor Radionuclide Therapy with <sup>177</sup>Lu[Lu]-DOTATOC |
| title_full_unstemmed | The Dependence of Renal <sup>68</sup>Ga[Ga]-DOTATOC Uptake on Kidney Function and Its Relevance for Peptide Receptor Radionuclide Therapy with <sup>177</sup>Lu[Lu]-DOTATOC |
| title_short | The Dependence of Renal <sup>68</sup>Ga[Ga]-DOTATOC Uptake on Kidney Function and Its Relevance for Peptide Receptor Radionuclide Therapy with <sup>177</sup>Lu[Lu]-DOTATOC |
| title_sort | dependence of renal sup 68 sup ga ga dotatoc uptake on kidney function and its relevance for peptide receptor radionuclide therapy with sup 177 sup lu lu dotatoc |
| topic | DOTATOC PET/CT PRRT kidney function |
| url | https://www.mdpi.com/2075-4418/11/7/1216 |
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