Point-of-Care Tests for HIV Drug Resistance Monitoring: Advances and Potentials
HIV/AIDS is a global public health crisis that is yet to be contained. Effective management of HIV drug resistance (HIVDR) supported by close resistance monitoring is essential in achieving the WHO 95-95-95 targets, aiming to end the AIDS epidemic by 2030. Point-of-care tests (POCT) enable decentral...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/11/7/724 |
| _version_ | 1827627446420111360 |
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| author | Rayeil J. Chua Rupert Capiña Hezhao Ji |
| author_facet | Rayeil J. Chua Rupert Capiña Hezhao Ji |
| author_sort | Rayeil J. Chua |
| collection | DOAJ |
| description | HIV/AIDS is a global public health crisis that is yet to be contained. Effective management of HIV drug resistance (HIVDR) supported by close resistance monitoring is essential in achieving the WHO 95-95-95 targets, aiming to end the AIDS epidemic by 2030. Point-of-care tests (POCT) enable decentralized HIVDR testing with a short turnaround time and minimal instrumental requirement, allowing timely initiation of effective antiretroviral therapy (ART) and regimen adjustment as needed. HIVDR POCT is of particular significance in an era when ART access is scaling up at a global level and enhanced HIVDR monitoring is urgently needed, especially for low-to-middle-income countries. This article provides an overview of the currently available technologies that have been applied or potentially used in HIVDR POCT. It may also benefit the continued research and development efforts toward more innovative HIVDR diagnostics. |
| first_indexed | 2024-03-09T13:13:15Z |
| format | Article |
| id | doaj.art-2db6f617c1e54aa69025d052683718ab |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-09T13:13:15Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-2db6f617c1e54aa69025d052683718ab2023-11-30T21:38:52ZengMDPI AGPathogens2076-08172022-06-0111772410.3390/pathogens11070724Point-of-Care Tests for HIV Drug Resistance Monitoring: Advances and PotentialsRayeil J. Chua0Rupert Capiña1Hezhao Ji2National Microbiology Laboratory at JC Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, CanadaNational Microbiology Laboratory at JC Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, CanadaNational Microbiology Laboratory at JC Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, CanadaHIV/AIDS is a global public health crisis that is yet to be contained. Effective management of HIV drug resistance (HIVDR) supported by close resistance monitoring is essential in achieving the WHO 95-95-95 targets, aiming to end the AIDS epidemic by 2030. Point-of-care tests (POCT) enable decentralized HIVDR testing with a short turnaround time and minimal instrumental requirement, allowing timely initiation of effective antiretroviral therapy (ART) and regimen adjustment as needed. HIVDR POCT is of particular significance in an era when ART access is scaling up at a global level and enhanced HIVDR monitoring is urgently needed, especially for low-to-middle-income countries. This article provides an overview of the currently available technologies that have been applied or potentially used in HIVDR POCT. It may also benefit the continued research and development efforts toward more innovative HIVDR diagnostics.https://www.mdpi.com/2076-0817/11/7/724HIVdrug resistancepoint-of-care testresource-limited setting |
| spellingShingle | Rayeil J. Chua Rupert Capiña Hezhao Ji Point-of-Care Tests for HIV Drug Resistance Monitoring: Advances and Potentials Pathogens HIV drug resistance point-of-care test resource-limited setting |
| title | Point-of-Care Tests for HIV Drug Resistance Monitoring: Advances and Potentials |
| title_full | Point-of-Care Tests for HIV Drug Resistance Monitoring: Advances and Potentials |
| title_fullStr | Point-of-Care Tests for HIV Drug Resistance Monitoring: Advances and Potentials |
| title_full_unstemmed | Point-of-Care Tests for HIV Drug Resistance Monitoring: Advances and Potentials |
| title_short | Point-of-Care Tests for HIV Drug Resistance Monitoring: Advances and Potentials |
| title_sort | point of care tests for hiv drug resistance monitoring advances and potentials |
| topic | HIV drug resistance point-of-care test resource-limited setting |
| url | https://www.mdpi.com/2076-0817/11/7/724 |
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