Healthy lifestyle and genomic ancestry related to good glycemic control in type 1 diabetes patients from Northeastern Brazil: a hierarchical analysis
IntroductionThis study aimed to investigate the sociodemographic factors, dietary adherence, regular physical activity, and genomic ancestry percentage associated with good glycemic control in Brazilian patients with type 1 diabetes (T1D) using a hierarchical approach.MethodsA cross-sectional study...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-10-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1233050/full |
| _version_ | 1797660630689251328 |
|---|---|
| author | Rossana Santiago de Sousa Azulay Rossana Santiago de Sousa Azulay Vandilson Rodrigues Joana D’Arc Matos França de Abreu Joana D’Arc Matos França de Abreu Ana Gregória Ferreira Pereira de Almeida Débora Lago Débora Lago Maria da Glória Tavares Maria da Glória Tavares Gilvan Nascimento Gilvan Nascimento Viviane Rocha Viviane Rocha Marcelo Magalhães Marcelo Magalhães Alexandre Facundo Alexandre Facundo Clariano Pires de Oliveira Neto Clariano Pires de Oliveira Neto Adriana Guimarães Sá Conceição Ribeiro Veiga Parente Conceição Ribeiro Veiga Parente Dayse Aparecida Silva Marília Brito Gomes Manuel dos Santos Faria Manuel dos Santos Faria |
| author_facet | Rossana Santiago de Sousa Azulay Rossana Santiago de Sousa Azulay Vandilson Rodrigues Joana D’Arc Matos França de Abreu Joana D’Arc Matos França de Abreu Ana Gregória Ferreira Pereira de Almeida Débora Lago Débora Lago Maria da Glória Tavares Maria da Glória Tavares Gilvan Nascimento Gilvan Nascimento Viviane Rocha Viviane Rocha Marcelo Magalhães Marcelo Magalhães Alexandre Facundo Alexandre Facundo Clariano Pires de Oliveira Neto Clariano Pires de Oliveira Neto Adriana Guimarães Sá Conceição Ribeiro Veiga Parente Conceição Ribeiro Veiga Parente Dayse Aparecida Silva Marília Brito Gomes Manuel dos Santos Faria Manuel dos Santos Faria |
| author_sort | Rossana Santiago de Sousa Azulay |
| collection | DOAJ |
| description | IntroductionThis study aimed to investigate the sociodemographic factors, dietary adherence, regular physical activity, and genomic ancestry percentage associated with good glycemic control in Brazilian patients with type 1 diabetes (T1D) using a hierarchical approach.MethodsA cross-sectional study was conducted in 152 T1D patients. Glycated hemoglobin (HbA1C) levels were measured to evaluate the glycemic control status (good, moderate, or poor). Independent factors included sex, age, self-reported skin color, educational level, family income, dietary patterns, and physical activity. The percentage of genomic ancestry (Native American, European, and African) was influenced by a panel of 46 autosomal insertion/deletion ancestry markers. Statistical analyses included receiver operating characteristic curves, and hierarchical logistic regression analysis.ResultsThe hierarchical analysis, patients who had high dietary adherence showed a positive association with good glycemic control (adjustedOR = 2.56, 95% CI:1.18-5.59, P = 0.016). Thus, age greater than 40 years was associated with good glycemic control compared to the children and adolescents group (adjustedOR = 4.55, 95% CI:1.14-18.1, P = 0.031). Males were associated with good glycemic control (adjustedOR = 2.00, 95% CI:1.01-4.00, P =0.047).ConclusionThe study findings suggest that consistent adherence to dietary regimens is associated with good glycemic control after adjusting for sociodemographic and genomic ancestry factors in an admixed population of T1D patients from Northeast Brazil. |
| first_indexed | 2024-03-11T18:33:42Z |
| format | Article |
| id | doaj.art-2db9f5ce981a405d8ed62f6d29f06c8d |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-11T18:33:42Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-2db9f5ce981a405d8ed62f6d29f06c8d2023-10-13T07:28:52ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-10-011410.3389/fendo.2023.12330501233050Healthy lifestyle and genomic ancestry related to good glycemic control in type 1 diabetes patients from Northeastern Brazil: a hierarchical analysisRossana Santiago de Sousa Azulay0Rossana Santiago de Sousa Azulay1Vandilson Rodrigues2Joana D’Arc Matos França de Abreu3Joana D’Arc Matos França de Abreu4Ana Gregória Ferreira Pereira de Almeida5Débora Lago6Débora Lago7Maria da Glória Tavares8Maria da Glória Tavares9Gilvan Nascimento10Gilvan Nascimento11Viviane Rocha12Viviane Rocha13Marcelo Magalhães14Marcelo Magalhães15Alexandre Facundo16Alexandre Facundo17Clariano Pires de Oliveira Neto18Clariano Pires de Oliveira Neto19Adriana Guimarães Sá20Conceição Ribeiro Veiga Parente21Conceição Ribeiro Veiga Parente22Dayse Aparecida Silva23Marília Brito Gomes24Manuel dos Santos Faria25Manuel dos Santos Faria26Service of Endocrinology, University Hospital of the Federal University of Maranhão (HUUFMA), São Luís, BrazilResearch Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), Federal University of Maranhão, São Luís, BrazilResearch Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), Federal University of Maranhão, São Luís, BrazilService of Endocrinology, University Hospital of the Federal University of Maranhão (HUUFMA), São Luís, BrazilResearch Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), Federal University of Maranhão, São Luís, BrazilResearch Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), Federal University of Maranhão, São Luís, BrazilService of Endocrinology, University Hospital of the Federal University of Maranhão (HUUFMA), São Luís, BrazilResearch Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), Federal University of Maranhão, São Luís, BrazilService of Endocrinology, University Hospital of the Federal University of Maranhão (HUUFMA), São Luís, BrazilResearch Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), Federal University of Maranhão, São Luís, BrazilService of Endocrinology, University Hospital of the Federal University of Maranhão (HUUFMA), São Luís, BrazilResearch Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), Federal University of Maranhão, São Luís, BrazilService of Endocrinology, University Hospital of the Federal University of Maranhão (HUUFMA), São Luís, BrazilResearch Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), Federal University of Maranhão, São Luís, BrazilService of Endocrinology, University Hospital of the Federal University of Maranhão (HUUFMA), São Luís, BrazilResearch Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), Federal University of Maranhão, São Luís, BrazilService of Endocrinology, University Hospital of the Federal University of Maranhão (HUUFMA), São Luís, BrazilResearch Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), Federal University of Maranhão, São Luís, BrazilService of Endocrinology, University Hospital of the Federal University of Maranhão (HUUFMA), São Luís, BrazilResearch Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), Federal University of Maranhão, São Luís, BrazilResearch Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), Federal University of Maranhão, São Luís, BrazilService of Endocrinology, University Hospital of the Federal University of Maranhão (HUUFMA), São Luís, BrazilResearch Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), Federal University of Maranhão, São Luís, BrazilDNA Diagnostic Laboratory (LDD), Rio de Janeiro State University (UERJ), Rio de Janeiro, BrazilDiabetes Unit, Rio de Janeiro State University (UERJ), Rio de Janeiro, BrazilService of Endocrinology, University Hospital of the Federal University of Maranhão (HUUFMA), São Luís, BrazilResearch Group in Clinical and Molecular Endocrinology and Metabology (ENDOCLIM), Federal University of Maranhão, São Luís, BrazilIntroductionThis study aimed to investigate the sociodemographic factors, dietary adherence, regular physical activity, and genomic ancestry percentage associated with good glycemic control in Brazilian patients with type 1 diabetes (T1D) using a hierarchical approach.MethodsA cross-sectional study was conducted in 152 T1D patients. Glycated hemoglobin (HbA1C) levels were measured to evaluate the glycemic control status (good, moderate, or poor). Independent factors included sex, age, self-reported skin color, educational level, family income, dietary patterns, and physical activity. The percentage of genomic ancestry (Native American, European, and African) was influenced by a panel of 46 autosomal insertion/deletion ancestry markers. Statistical analyses included receiver operating characteristic curves, and hierarchical logistic regression analysis.ResultsThe hierarchical analysis, patients who had high dietary adherence showed a positive association with good glycemic control (adjustedOR = 2.56, 95% CI:1.18-5.59, P = 0.016). Thus, age greater than 40 years was associated with good glycemic control compared to the children and adolescents group (adjustedOR = 4.55, 95% CI:1.14-18.1, P = 0.031). Males were associated with good glycemic control (adjustedOR = 2.00, 95% CI:1.01-4.00, P =0.047).ConclusionThe study findings suggest that consistent adherence to dietary regimens is associated with good glycemic control after adjusting for sociodemographic and genomic ancestry factors in an admixed population of T1D patients from Northeast Brazil.https://www.frontiersin.org/articles/10.3389/fendo.2023.1233050/fulltype 1 diabetesmedical nutritional therapyphysical activitygenetic profileglycated hemoglobin |
| spellingShingle | Rossana Santiago de Sousa Azulay Rossana Santiago de Sousa Azulay Vandilson Rodrigues Joana D’Arc Matos França de Abreu Joana D’Arc Matos França de Abreu Ana Gregória Ferreira Pereira de Almeida Débora Lago Débora Lago Maria da Glória Tavares Maria da Glória Tavares Gilvan Nascimento Gilvan Nascimento Viviane Rocha Viviane Rocha Marcelo Magalhães Marcelo Magalhães Alexandre Facundo Alexandre Facundo Clariano Pires de Oliveira Neto Clariano Pires de Oliveira Neto Adriana Guimarães Sá Conceição Ribeiro Veiga Parente Conceição Ribeiro Veiga Parente Dayse Aparecida Silva Marília Brito Gomes Manuel dos Santos Faria Manuel dos Santos Faria Healthy lifestyle and genomic ancestry related to good glycemic control in type 1 diabetes patients from Northeastern Brazil: a hierarchical analysis Frontiers in Endocrinology type 1 diabetes medical nutritional therapy physical activity genetic profile glycated hemoglobin |
| title | Healthy lifestyle and genomic ancestry related to good glycemic control in type 1 diabetes patients from Northeastern Brazil: a hierarchical analysis |
| title_full | Healthy lifestyle and genomic ancestry related to good glycemic control in type 1 diabetes patients from Northeastern Brazil: a hierarchical analysis |
| title_fullStr | Healthy lifestyle and genomic ancestry related to good glycemic control in type 1 diabetes patients from Northeastern Brazil: a hierarchical analysis |
| title_full_unstemmed | Healthy lifestyle and genomic ancestry related to good glycemic control in type 1 diabetes patients from Northeastern Brazil: a hierarchical analysis |
| title_short | Healthy lifestyle and genomic ancestry related to good glycemic control in type 1 diabetes patients from Northeastern Brazil: a hierarchical analysis |
| title_sort | healthy lifestyle and genomic ancestry related to good glycemic control in type 1 diabetes patients from northeastern brazil a hierarchical analysis |
| topic | type 1 diabetes medical nutritional therapy physical activity genetic profile glycated hemoglobin |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1233050/full |
| work_keys_str_mv | AT rossanasantiagodesousaazulay healthylifestyleandgenomicancestryrelatedtogoodglycemiccontrolintype1diabetespatientsfromnortheasternbrazilahierarchicalanalysis AT rossanasantiagodesousaazulay healthylifestyleandgenomicancestryrelatedtogoodglycemiccontrolintype1diabetespatientsfromnortheasternbrazilahierarchicalanalysis AT vandilsonrodrigues healthylifestyleandgenomicancestryrelatedtogoodglycemiccontrolintype1diabetespatientsfromnortheasternbrazilahierarchicalanalysis AT joanadarcmatosfrancadeabreu healthylifestyleandgenomicancestryrelatedtogoodglycemiccontrolintype1diabetespatientsfromnortheasternbrazilahierarchicalanalysis AT joanadarcmatosfrancadeabreu healthylifestyleandgenomicancestryrelatedtogoodglycemiccontrolintype1diabetespatientsfromnortheasternbrazilahierarchicalanalysis AT anagregoriaferreirapereiradealmeida healthylifestyleandgenomicancestryrelatedtogoodglycemiccontrolintype1diabetespatientsfromnortheasternbrazilahierarchicalanalysis AT deboralago healthylifestyleandgenomicancestryrelatedtogoodglycemiccontrolintype1diabetespatientsfromnortheasternbrazilahierarchicalanalysis AT deboralago healthylifestyleandgenomicancestryrelatedtogoodglycemiccontrolintype1diabetespatientsfromnortheasternbrazilahierarchicalanalysis AT mariadagloriatavares healthylifestyleandgenomicancestryrelatedtogoodglycemiccontrolintype1diabetespatientsfromnortheasternbrazilahierarchicalanalysis AT mariadagloriatavares healthylifestyleandgenomicancestryrelatedtogoodglycemiccontrolintype1diabetespatientsfromnortheasternbrazilahierarchicalanalysis AT gilvannascimento healthylifestyleandgenomicancestryrelatedtogoodglycemiccontrolintype1diabetespatientsfromnortheasternbrazilahierarchicalanalysis AT gilvannascimento healthylifestyleandgenomicancestryrelatedtogoodglycemiccontrolintype1diabetespatientsfromnortheasternbrazilahierarchicalanalysis AT vivianerocha healthylifestyleandgenomicancestryrelatedtogoodglycemiccontrolintype1diabetespatientsfromnortheasternbrazilahierarchicalanalysis AT vivianerocha healthylifestyleandgenomicancestryrelatedtogoodglycemiccontrolintype1diabetespatientsfromnortheasternbrazilahierarchicalanalysis AT marcelomagalhaes healthylifestyleandgenomicancestryrelatedtogoodglycemiccontrolintype1diabetespatientsfromnortheasternbrazilahierarchicalanalysis AT marcelomagalhaes healthylifestyleandgenomicancestryrelatedtogoodglycemiccontrolintype1diabetespatientsfromnortheasternbrazilahierarchicalanalysis AT alexandrefacundo healthylifestyleandgenomicancestryrelatedtogoodglycemiccontrolintype1diabetespatientsfromnortheasternbrazilahierarchicalanalysis AT alexandrefacundo healthylifestyleandgenomicancestryrelatedtogoodglycemiccontrolintype1diabetespatientsfromnortheasternbrazilahierarchicalanalysis AT clarianopiresdeoliveiraneto healthylifestyleandgenomicancestryrelatedtogoodglycemiccontrolintype1diabetespatientsfromnortheasternbrazilahierarchicalanalysis AT clarianopiresdeoliveiraneto healthylifestyleandgenomicancestryrelatedtogoodglycemiccontrolintype1diabetespatientsfromnortheasternbrazilahierarchicalanalysis AT adrianaguimaraessa healthylifestyleandgenomicancestryrelatedtogoodglycemiccontrolintype1diabetespatientsfromnortheasternbrazilahierarchicalanalysis AT conceicaoribeiroveigaparente healthylifestyleandgenomicancestryrelatedtogoodglycemiccontrolintype1diabetespatientsfromnortheasternbrazilahierarchicalanalysis AT conceicaoribeiroveigaparente healthylifestyleandgenomicancestryrelatedtogoodglycemiccontrolintype1diabetespatientsfromnortheasternbrazilahierarchicalanalysis AT dayseaparecidasilva healthylifestyleandgenomicancestryrelatedtogoodglycemiccontrolintype1diabetespatientsfromnortheasternbrazilahierarchicalanalysis AT mariliabritogomes healthylifestyleandgenomicancestryrelatedtogoodglycemiccontrolintype1diabetespatientsfromnortheasternbrazilahierarchicalanalysis AT manueldossantosfaria healthylifestyleandgenomicancestryrelatedtogoodglycemiccontrolintype1diabetespatientsfromnortheasternbrazilahierarchicalanalysis AT manueldossantosfaria healthylifestyleandgenomicancestryrelatedtogoodglycemiccontrolintype1diabetespatientsfromnortheasternbrazilahierarchicalanalysis |