The Influence of Cross-Fostering on Alcohol Consumption and Depressive-Like Behaviors in HA and LA Mice: The Role of the Endogenous Opioid System
The development of alcohol dependence and depression is determined by various genetic and environmental factors. In the presented study, we used high analgesia (HA) and low analgesia (LA) mouse lines, characterized by different endogenous opioid system activity and divergent blood–brain barrier perm...
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MDPI AG
2021-05-01
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| author | Agata Nawrocka Piotr Poznański Marzena Łazarczyk Michał Gorzałczyński Dominik Skiba Renata Wolińska Magdalena Bujalska-Zadrożny Kabirullah Lutfy Bogdan Sadowski Mariusz Sacharczuk |
| author_facet | Agata Nawrocka Piotr Poznański Marzena Łazarczyk Michał Gorzałczyński Dominik Skiba Renata Wolińska Magdalena Bujalska-Zadrożny Kabirullah Lutfy Bogdan Sadowski Mariusz Sacharczuk |
| author_sort | Agata Nawrocka |
| collection | DOAJ |
| description | The development of alcohol dependence and depression is determined by various genetic and environmental factors. In the presented study, we used high analgesia (HA) and low analgesia (LA) mouse lines, characterized by different endogenous opioid system activity and divergent blood–brain barrier permeability, to determine the influence of cross-fostering of these lines raised by surrogate mothers on ethanol consumption and development of depressive-like behaviors. We also investigated ethanol drinking by biological parents or surrogate mothers. Furthermore, we investigated whether these parental changes would alter the effect of naloxone on ethanol intake and depressive-like behaviors in offspring. Our results reveal that cross-fostering of HA and LA raised by surrogate mothers has a greater impact on depressive-like behaviors than ethanol consumption. Ethanol intake by biological parents substantially affected depressive-like behaviors and ethanol consumption in offspring. Moreover, ethanol intake by biological parents or an adoptive mother modified the effect of naloxone on ethanol consumption and preference and depressive-like behaviors in the HA offspring only. Together, these results indicate that cross-fostering differentially affects the effect of naloxone on alcohol consumption and the development of depression. |
| first_indexed | 2024-03-10T11:27:32Z |
| format | Article |
| id | doaj.art-2dba8448220f4fd09f1f4a5dcad8474a |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T11:27:32Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-2dba8448220f4fd09f1f4a5dcad8474a2023-11-21T19:28:34ZengMDPI AGBrain Sciences2076-34252021-05-0111562210.3390/brainsci11050622The Influence of Cross-Fostering on Alcohol Consumption and Depressive-Like Behaviors in HA and LA Mice: The Role of the Endogenous Opioid SystemAgata Nawrocka0Piotr Poznański1Marzena Łazarczyk2Michał Gorzałczyński3Dominik Skiba4Renata Wolińska5Magdalena Bujalska-Zadrożny6Kabirullah Lutfy7Bogdan Sadowski8Mariusz Sacharczuk9Department of Experimental Genomics, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, 05-552 Magdalenka, PolandDepartment of Experimental Genomics, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, 05-552 Magdalenka, PolandDepartment of Experimental Genomics, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, 05-552 Magdalenka, PolandDepartment of Pharmacodynamics, Centre for Preclinical Research and Technology, Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Experimental Genomics, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, 05-552 Magdalenka, PolandDepartment of Pharmacodynamics, Centre for Preclinical Research and Technology, Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Pharmacodynamics, Centre for Preclinical Research and Technology, Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USAWarsaw School of Engineering and Health, 02-366 Warsaw, PolandDepartment of Experimental Genomics, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, 05-552 Magdalenka, PolandThe development of alcohol dependence and depression is determined by various genetic and environmental factors. In the presented study, we used high analgesia (HA) and low analgesia (LA) mouse lines, characterized by different endogenous opioid system activity and divergent blood–brain barrier permeability, to determine the influence of cross-fostering of these lines raised by surrogate mothers on ethanol consumption and development of depressive-like behaviors. We also investigated ethanol drinking by biological parents or surrogate mothers. Furthermore, we investigated whether these parental changes would alter the effect of naloxone on ethanol intake and depressive-like behaviors in offspring. Our results reveal that cross-fostering of HA and LA raised by surrogate mothers has a greater impact on depressive-like behaviors than ethanol consumption. Ethanol intake by biological parents substantially affected depressive-like behaviors and ethanol consumption in offspring. Moreover, ethanol intake by biological parents or an adoptive mother modified the effect of naloxone on ethanol consumption and preference and depressive-like behaviors in the HA offspring only. Together, these results indicate that cross-fostering differentially affects the effect of naloxone on alcohol consumption and the development of depression.https://www.mdpi.com/2076-3425/11/5/622ethanol dependencedepressionthe opioid systemstress-induced analgesiacross-fostering |
| spellingShingle | Agata Nawrocka Piotr Poznański Marzena Łazarczyk Michał Gorzałczyński Dominik Skiba Renata Wolińska Magdalena Bujalska-Zadrożny Kabirullah Lutfy Bogdan Sadowski Mariusz Sacharczuk The Influence of Cross-Fostering on Alcohol Consumption and Depressive-Like Behaviors in HA and LA Mice: The Role of the Endogenous Opioid System Brain Sciences ethanol dependence depression the opioid system stress-induced analgesia cross-fostering |
| title | The Influence of Cross-Fostering on Alcohol Consumption and Depressive-Like Behaviors in HA and LA Mice: The Role of the Endogenous Opioid System |
| title_full | The Influence of Cross-Fostering on Alcohol Consumption and Depressive-Like Behaviors in HA and LA Mice: The Role of the Endogenous Opioid System |
| title_fullStr | The Influence of Cross-Fostering on Alcohol Consumption and Depressive-Like Behaviors in HA and LA Mice: The Role of the Endogenous Opioid System |
| title_full_unstemmed | The Influence of Cross-Fostering on Alcohol Consumption and Depressive-Like Behaviors in HA and LA Mice: The Role of the Endogenous Opioid System |
| title_short | The Influence of Cross-Fostering on Alcohol Consumption and Depressive-Like Behaviors in HA and LA Mice: The Role of the Endogenous Opioid System |
| title_sort | influence of cross fostering on alcohol consumption and depressive like behaviors in ha and la mice the role of the endogenous opioid system |
| topic | ethanol dependence depression the opioid system stress-induced analgesia cross-fostering |
| url | https://www.mdpi.com/2076-3425/11/5/622 |
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