Soothing and anti-itch effect of quercetin phytosome in human subjects: a single-blind study
Giada Maramaldi,1 Stefano Togni,1 Ivan Pagin,1 Luca Giacomelli,2 Roberta Cattaneo,3 Roberto Eggenhöffner,2 Samuele E Burastero4 1Indena S.p.A, Milan, 2Department of Surgical Sciences and Integrated Diagnostics, School of Medicine, Genova University, Genoa, 3Abich Srl, Verbania, 4San Raffael...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2016-02-01
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| Series: | Clinical, Cosmetic and Investigational Dermatology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/soothing-and-anti-itch-effect-of-quercetin-phytosome-in-human-subjects-peer-reviewed-article-CCID |
| _version_ | 1819126463613370368 |
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| author | Maramaldi G Togni S Pagin I Giacomelli L Cattaneo R Eggenhöffner R Burastero SE |
| author_facet | Maramaldi G Togni S Pagin I Giacomelli L Cattaneo R Eggenhöffner R Burastero SE |
| author_sort | Maramaldi G |
| collection | DOAJ |
| description | Giada Maramaldi,1 Stefano Togni,1 Ivan Pagin,1 Luca Giacomelli,2 Roberta Cattaneo,3 Roberto Eggenhöffner,2 Samuele E Burastero4 1Indena S.p.A, Milan, 2Department of Surgical Sciences and Integrated Diagnostics, School of Medicine, Genova University, Genoa, 3Abich Srl, Verbania, 4San Raffaele Scientific Institute, Milan, ItalyBackground: We evaluated the ability of quercetin, a natural antioxidant formulated in a specific delivery system, to reduce skin inflammation induced by a variety of stimuli, including UV radiation, stimulation with a histamine solution, or contact with chemical irritants. In particular, we tested the soothing and anti-itch effect of Quercevita®, 1% cream for external use, a formulation characterized by a phospholipids-based delivery system.Patients and methods: The study was a monocentric, single blind trial that enrolled a group of 30 healthy volunteers. The back of each subject was examined to identify four quadrants with no previous skin damage or naevi that were treated in order to induce a controlled and reversible form of skin stress. The areas were treated as follows: no product; Quercevita® 1% cream, 2 mg/cm2; placebo; positive control (a commercially available topical formulation containing 1% dexchlorpheniramine).Results: Only quercetin phospholipids 1% and dexchlorpheniramine 1% achieved a significant reduction in erythema with comparable results: (–10.05% [P=0.00329] for quercetin phospholipids 1% vs –14.05% [P=0.00046] for the positive control). Moreover, quercetin phospholipids 1% and dexchlorpheniramine 1% were both associated with a significant decrease in mean wheal diameter: (–13.25% and –12.23% for dexchlorpheniramine 1%, respectively). Similar findings were reported for the other tested parameters.Conclusion: Quercetin has a skin protective effect against damage caused by a variety of insults, including UV radiation, histamine, or contact with toxic chemical compounds. Indeed, quercetin is able to reduce redness, itching, and inflammation of damaged skin; it may also help restore skin barrier function, increasing hydration, and reducing water loss.Keywords: quercetin, anti-oxidant effect, anti-inflammation, reactive oxygen species |
| first_indexed | 2024-12-22T07:56:26Z |
| format | Article |
| id | doaj.art-2dbb039a06f0456a8faf79cd6afdbeee |
| institution | Directory Open Access Journal |
| issn | 1178-7015 |
| language | English |
| last_indexed | 2024-12-22T07:56:26Z |
| publishDate | 2016-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical, Cosmetic and Investigational Dermatology |
| spelling | doaj.art-2dbb039a06f0456a8faf79cd6afdbeee2022-12-21T18:33:21ZengDove Medical PressClinical, Cosmetic and Investigational Dermatology1178-70152016-02-012016Issue 1556225746Soothing and anti-itch effect of quercetin phytosome in human subjects: a single-blind studyMaramaldi GTogni SPagin IGiacomelli LCattaneo REggenhöffner RBurastero SEGiada Maramaldi,1 Stefano Togni,1 Ivan Pagin,1 Luca Giacomelli,2 Roberta Cattaneo,3 Roberto Eggenhöffner,2 Samuele E Burastero4 1Indena S.p.A, Milan, 2Department of Surgical Sciences and Integrated Diagnostics, School of Medicine, Genova University, Genoa, 3Abich Srl, Verbania, 4San Raffaele Scientific Institute, Milan, ItalyBackground: We evaluated the ability of quercetin, a natural antioxidant formulated in a specific delivery system, to reduce skin inflammation induced by a variety of stimuli, including UV radiation, stimulation with a histamine solution, or contact with chemical irritants. In particular, we tested the soothing and anti-itch effect of Quercevita®, 1% cream for external use, a formulation characterized by a phospholipids-based delivery system.Patients and methods: The study was a monocentric, single blind trial that enrolled a group of 30 healthy volunteers. The back of each subject was examined to identify four quadrants with no previous skin damage or naevi that were treated in order to induce a controlled and reversible form of skin stress. The areas were treated as follows: no product; Quercevita® 1% cream, 2 mg/cm2; placebo; positive control (a commercially available topical formulation containing 1% dexchlorpheniramine).Results: Only quercetin phospholipids 1% and dexchlorpheniramine 1% achieved a significant reduction in erythema with comparable results: (–10.05% [P=0.00329] for quercetin phospholipids 1% vs –14.05% [P=0.00046] for the positive control). Moreover, quercetin phospholipids 1% and dexchlorpheniramine 1% were both associated with a significant decrease in mean wheal diameter: (–13.25% and –12.23% for dexchlorpheniramine 1%, respectively). Similar findings were reported for the other tested parameters.Conclusion: Quercetin has a skin protective effect against damage caused by a variety of insults, including UV radiation, histamine, or contact with toxic chemical compounds. Indeed, quercetin is able to reduce redness, itching, and inflammation of damaged skin; it may also help restore skin barrier function, increasing hydration, and reducing water loss.Keywords: quercetin, anti-oxidant effect, anti-inflammation, reactive oxygen specieshttps://www.dovepress.com/soothing-and-anti-itch-effect-of-quercetin-phytosome-in-human-subjects-peer-reviewed-article-CCIDquercetinanti-oxidant effectanti-inflammationreactive oxygen species |
| spellingShingle | Maramaldi G Togni S Pagin I Giacomelli L Cattaneo R Eggenhöffner R Burastero SE Soothing and anti-itch effect of quercetin phytosome in human subjects: a single-blind study Clinical, Cosmetic and Investigational Dermatology quercetin anti-oxidant effect anti-inflammation reactive oxygen species |
| title | Soothing and anti-itch effect of quercetin phytosome in human subjects: a single-blind study |
| title_full | Soothing and anti-itch effect of quercetin phytosome in human subjects: a single-blind study |
| title_fullStr | Soothing and anti-itch effect of quercetin phytosome in human subjects: a single-blind study |
| title_full_unstemmed | Soothing and anti-itch effect of quercetin phytosome in human subjects: a single-blind study |
| title_short | Soothing and anti-itch effect of quercetin phytosome in human subjects: a single-blind study |
| title_sort | soothing and anti itch effect of quercetin phytosome in human subjects a single blind study |
| topic | quercetin anti-oxidant effect anti-inflammation reactive oxygen species |
| url | https://www.dovepress.com/soothing-and-anti-itch-effect-of-quercetin-phytosome-in-human-subjects-peer-reviewed-article-CCID |
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