Genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia

Genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia

Pre-leukaemic clones, together with the propensity to cause disease in mice, are characterized by appearing early in myeloid leukaemia and being found at relapse. Here, the authors identify clones in human samples and find that they are characterized by hierarchically organized genetic lesions, whic...

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Bibliografski detalji
Glavni autori: Pierre Hirsch, Yanyan Zhang, Ruoping Tang, Virginie Joulin, Hélène Boutroux, Elodie Pronier, Hannah Moatti, Pascale Flandrin, Christophe Marzac, Dominique Bories, Fanny Fava, Hayat Mokrani, Aline Betems, Florence Lorre, Rémi Favier, Frédéric Féger, Mohamad Mohty, Luc Douay, Ollivier Legrand, Chrystèle Bilhou-Nabera, Fawzia Louache, François Delhommeau
Format: Članak
Jezik:English
Izdano: Nature Portfolio 2016-08-01
Serija:Nature Communications
Online pristup:https://doi.org/10.1038/ncomms12475

Internet

https://doi.org/10.1038/ncomms12475

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