Cytotoxic, Scolicidal, and Insecticidal Activities of <i>Lavandula stoechas</i> Essential Oil

Essential oils (EOs) have recently attracted more interest due to their insecticidal activities, low harmfulness, and rapid degradation in the environment. Therefore, <i>Lavandula steochas</i> (<i>L. steochas</i>) essential oil was assessed for its chemical constituents, in v...

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Main Authors: Abdel-Azeem S. Abdel-Baki, Shawky M. Aboelhadid, Saleh Al-Quraishy, Ahmed O. Hassan, Dimitra Daferera, Atalay Sokmen, Asmaa A. Kamel
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Separations
Subjects:
Online Access:https://www.mdpi.com/2297-8739/10/2/100
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author Abdel-Azeem S. Abdel-Baki
Shawky M. Aboelhadid
Saleh Al-Quraishy
Ahmed O. Hassan
Dimitra Daferera
Atalay Sokmen
Asmaa A. Kamel
author_facet Abdel-Azeem S. Abdel-Baki
Shawky M. Aboelhadid
Saleh Al-Quraishy
Ahmed O. Hassan
Dimitra Daferera
Atalay Sokmen
Asmaa A. Kamel
author_sort Abdel-Azeem S. Abdel-Baki
collection DOAJ
description Essential oils (EOs) have recently attracted more interest due to their insecticidal activities, low harmfulness, and rapid degradation in the environment. Therefore, <i>Lavandula steochas</i> (<i>L. steochas</i>) essential oil was assessed for its chemical constituents, in vitro cytotoxicity, and scolicidal, acaricidal, and insecticidal activities. Using spectrometry and gas chromatography, the components of L. steochas EOs were detected. Additionally, different oil concentrations were tested for their anticancer activities when applied to human embryonic kidney cells (HEK-293 cells) and the human breast cancer cell line MCF-7. The oil’s scolicidal activity against protoscolices of hydatid cysts was evaluated at various concentrations and exposure times. The oil’s adulticidal, larvicidal, and repelling effects on <i>R. annulatus</i> ticks were also investigated at various concentrations, ranging from 0.625 to 10%. Likewise, the larvicidal and pupicidal activities of <i>L. steochas</i> against <i>Musca domestica</i> were estimated at different concentrations. The analyses of <i>L. steochas</i> oil identified camphor as the predominant compound (58.38%). <i>L. steochas</i> oil showed significant cytotoxicity against cancer cells. All of the tested oil concentrations demonstrated significant scolicidal activities against the protoscoleces of hydatid cysts. <i>L. steochas</i> EO (essential oil) showed 100% adulticidal activity against <i>R. annulatus</i> at a 10% concentration with an LC<sub>50</sub> of 2.34%, whereas the larvicidal activity was 86.67% and the LC<sub>50</sub> was 9.11%. On the other hand, the oil showed no repellent activity against this tick’s larva. Furthermore, <i>L. steochas</i> EO achieved 100% larvicidal and pupicidal effects against <i>M. domestica</i> at a 10% concentration with LC<sub>50</sub> values of 1.79% and 1.51%, respectively. In conclusion, the current work suggests that <i>L. steochas</i> EO could serve as a potential source of scolicidal, acaricidal, insecticidal, and anticancer agents.
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spelling doaj.art-2dbc6c2197c94ecd993d39188ac3b8f02023-11-16T23:14:20ZengMDPI AGSeparations2297-87392023-02-0110210010.3390/separations10020100Cytotoxic, Scolicidal, and Insecticidal Activities of <i>Lavandula stoechas</i> Essential OilAbdel-Azeem S. Abdel-Baki0Shawky M. Aboelhadid1Saleh Al-Quraishy2Ahmed O. Hassan3Dimitra Daferera4Atalay Sokmen5Asmaa A. Kamel6Zoology Department, Faculty of Science, Beni-Suef University, Beni-Suef 62511, EgyptParasitology Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef 62511, EgyptZoology Department, College of Science, King Saud University, Riyadh 11564, Saudi ArabiaDepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USALaboratory of General Chemistry, Agricultural University of Athens, Iera Odos 75, 118 55 Athens, GreeceDepartment of Plant Production and Technologies, Faculty of Agriculture and Natural Sciences, Konya Food and Agriculture University, Konya 42080, TurkeyParasitology Department, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef 62511, EgyptEssential oils (EOs) have recently attracted more interest due to their insecticidal activities, low harmfulness, and rapid degradation in the environment. Therefore, <i>Lavandula steochas</i> (<i>L. steochas</i>) essential oil was assessed for its chemical constituents, in vitro cytotoxicity, and scolicidal, acaricidal, and insecticidal activities. Using spectrometry and gas chromatography, the components of L. steochas EOs were detected. Additionally, different oil concentrations were tested for their anticancer activities when applied to human embryonic kidney cells (HEK-293 cells) and the human breast cancer cell line MCF-7. The oil’s scolicidal activity against protoscolices of hydatid cysts was evaluated at various concentrations and exposure times. The oil’s adulticidal, larvicidal, and repelling effects on <i>R. annulatus</i> ticks were also investigated at various concentrations, ranging from 0.625 to 10%. Likewise, the larvicidal and pupicidal activities of <i>L. steochas</i> against <i>Musca domestica</i> were estimated at different concentrations. The analyses of <i>L. steochas</i> oil identified camphor as the predominant compound (58.38%). <i>L. steochas</i> oil showed significant cytotoxicity against cancer cells. All of the tested oil concentrations demonstrated significant scolicidal activities against the protoscoleces of hydatid cysts. <i>L. steochas</i> EO (essential oil) showed 100% adulticidal activity against <i>R. annulatus</i> at a 10% concentration with an LC<sub>50</sub> of 2.34%, whereas the larvicidal activity was 86.67% and the LC<sub>50</sub> was 9.11%. On the other hand, the oil showed no repellent activity against this tick’s larva. Furthermore, <i>L. steochas</i> EO achieved 100% larvicidal and pupicidal effects against <i>M. domestica</i> at a 10% concentration with LC<sub>50</sub> values of 1.79% and 1.51%, respectively. In conclusion, the current work suggests that <i>L. steochas</i> EO could serve as a potential source of scolicidal, acaricidal, insecticidal, and anticancer agents.https://www.mdpi.com/2297-8739/10/2/100lavender oilcytotoxicscolicidalMusca domesticaacaricide
spellingShingle Abdel-Azeem S. Abdel-Baki
Shawky M. Aboelhadid
Saleh Al-Quraishy
Ahmed O. Hassan
Dimitra Daferera
Atalay Sokmen
Asmaa A. Kamel
Cytotoxic, Scolicidal, and Insecticidal Activities of <i>Lavandula stoechas</i> Essential Oil
Separations
lavender oil
cytotoxic
scolicidal
Musca domestica
acaricide
title Cytotoxic, Scolicidal, and Insecticidal Activities of <i>Lavandula stoechas</i> Essential Oil
title_full Cytotoxic, Scolicidal, and Insecticidal Activities of <i>Lavandula stoechas</i> Essential Oil
title_fullStr Cytotoxic, Scolicidal, and Insecticidal Activities of <i>Lavandula stoechas</i> Essential Oil
title_full_unstemmed Cytotoxic, Scolicidal, and Insecticidal Activities of <i>Lavandula stoechas</i> Essential Oil
title_short Cytotoxic, Scolicidal, and Insecticidal Activities of <i>Lavandula stoechas</i> Essential Oil
title_sort cytotoxic scolicidal and insecticidal activities of i lavandula stoechas i essential oil
topic lavender oil
cytotoxic
scolicidal
Musca domestica
acaricide
url https://www.mdpi.com/2297-8739/10/2/100
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