High-flow nasal oxygen reduces the incidence of hypoxia in sedated hysteroscopy for assisted reproduction
Backgrounds and aimsPain is the main reason for hysteroscopy failure. In day-surgical settings, hysteroscopy procedures are commonly performed with the patient under sedation. Hypoxia is the most common adverse event during sedation and can lead to severe adverse events. This study aimed to compare...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.929096/full |
| _version_ | 1818503489421049856 |
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| author | Ying Tang Ping Huang Di Chai Xiao Zhang Xiaoyi Zhang Shaoyi Chen Diansan Su Yonglei Huang |
| author_facet | Ying Tang Ping Huang Di Chai Xiao Zhang Xiaoyi Zhang Shaoyi Chen Diansan Su Yonglei Huang |
| author_sort | Ying Tang |
| collection | DOAJ |
| description | Backgrounds and aimsPain is the main reason for hysteroscopy failure. In day-surgical settings, hysteroscopy procedures are commonly performed with the patient under sedation. Hypoxia is the most common adverse event during sedation and can lead to severe adverse events. This study aimed to compare the incidence of hypoxia when using high-flow nasal oxygen (HFNO) with that when using regular nasal oxygen in patients undergoing hysteroscopy with sedation.Materials and methodsIn this single-center, prospective, randomized, single-blinded study, 960 female patients undergoing elective diagnostic or operative hysteroscopy were randomly enrolled into the following two groups: the regular nasal group [O2 (3–6 L/min) covered by an HFNO] and the HFNO group [O2 (30–60 L/min)] from September 2021 to December 2021. All women were sedated with propofol (1.5 mg/kg) and remifentanil (1.5 μg/kg) in the operating room. The primary outcome was the incidence of hypoxia (75% ≤ SpO2 < 90%, < 60 s).ResultsHFNO decreased the incidence of hypoxia (75% ≤ SpO2 < 90%, < 60 s), subclinical respiratory depression (90% ≤ SpO2 < 95%) and severe hypoxia (SpO2 < 75% for any duration or 75% ≤ SpO2 < 90% for ≥ 60 s) from 24.38 to 0.83%, from 11.25 to 1.46% and from 3.75 to 0%, respectively (P < 0.001).ConclusionIn procedures conducted to treat female infertility, HFNO can reduce hypoxia during hysteroscopy in patients sedated with propofol, and it can prevent the occurrence of subclinical respiratory depression and severe hypoxia. |
| first_indexed | 2024-12-10T21:24:40Z |
| format | Article |
| id | doaj.art-2dbcaf22c1a446d88fd81bc2f0ff370b |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-10T21:24:40Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-2dbcaf22c1a446d88fd81bc2f0ff370b2022-12-22T01:33:02ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-08-01910.3389/fmed.2022.929096929096High-flow nasal oxygen reduces the incidence of hypoxia in sedated hysteroscopy for assisted reproductionYing TangPing HuangDi ChaiXiao ZhangXiaoyi ZhangShaoyi ChenDiansan SuYonglei HuangBackgrounds and aimsPain is the main reason for hysteroscopy failure. In day-surgical settings, hysteroscopy procedures are commonly performed with the patient under sedation. Hypoxia is the most common adverse event during sedation and can lead to severe adverse events. This study aimed to compare the incidence of hypoxia when using high-flow nasal oxygen (HFNO) with that when using regular nasal oxygen in patients undergoing hysteroscopy with sedation.Materials and methodsIn this single-center, prospective, randomized, single-blinded study, 960 female patients undergoing elective diagnostic or operative hysteroscopy were randomly enrolled into the following two groups: the regular nasal group [O2 (3–6 L/min) covered by an HFNO] and the HFNO group [O2 (30–60 L/min)] from September 2021 to December 2021. All women were sedated with propofol (1.5 mg/kg) and remifentanil (1.5 μg/kg) in the operating room. The primary outcome was the incidence of hypoxia (75% ≤ SpO2 < 90%, < 60 s).ResultsHFNO decreased the incidence of hypoxia (75% ≤ SpO2 < 90%, < 60 s), subclinical respiratory depression (90% ≤ SpO2 < 95%) and severe hypoxia (SpO2 < 75% for any duration or 75% ≤ SpO2 < 90% for ≥ 60 s) from 24.38 to 0.83%, from 11.25 to 1.46% and from 3.75 to 0%, respectively (P < 0.001).ConclusionIn procedures conducted to treat female infertility, HFNO can reduce hypoxia during hysteroscopy in patients sedated with propofol, and it can prevent the occurrence of subclinical respiratory depression and severe hypoxia.https://www.frontiersin.org/articles/10.3389/fmed.2022.929096/fullhysteroscopyin vitro fertilizationhigh-flow nasal oxygenhypoxiadeep sedationpropofol |
| spellingShingle | Ying Tang Ping Huang Di Chai Xiao Zhang Xiaoyi Zhang Shaoyi Chen Diansan Su Yonglei Huang High-flow nasal oxygen reduces the incidence of hypoxia in sedated hysteroscopy for assisted reproduction Frontiers in Medicine hysteroscopy in vitro fertilization high-flow nasal oxygen hypoxia deep sedation propofol |
| title | High-flow nasal oxygen reduces the incidence of hypoxia in sedated hysteroscopy for assisted reproduction |
| title_full | High-flow nasal oxygen reduces the incidence of hypoxia in sedated hysteroscopy for assisted reproduction |
| title_fullStr | High-flow nasal oxygen reduces the incidence of hypoxia in sedated hysteroscopy for assisted reproduction |
| title_full_unstemmed | High-flow nasal oxygen reduces the incidence of hypoxia in sedated hysteroscopy for assisted reproduction |
| title_short | High-flow nasal oxygen reduces the incidence of hypoxia in sedated hysteroscopy for assisted reproduction |
| title_sort | high flow nasal oxygen reduces the incidence of hypoxia in sedated hysteroscopy for assisted reproduction |
| topic | hysteroscopy in vitro fertilization high-flow nasal oxygen hypoxia deep sedation propofol |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.929096/full |
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