FcαRI Dynamics Are Regulated by GSK-3 and PKCζ During Cytokine Mediated Inside-Out Signaling

FcαRI Dynamics Are Regulated by GSK-3 and PKCζ During Cytokine Mediated Inside-Out Signaling

IgA binding to FcαRI (CD89) is rapidly enhanced by cytokine induced inside-out signaling. Dephosphorylation of serine 263 in the intracellular tail of FcαRI by PP2A and PI3K activation are instrumental in this process. To further investigate these signaling pathways, we targeted downstream kinases o...

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Bibliographic Details
Main Authors: Toine ten Broeke, Henk Honing, Arianne M. Brandsma, Shamir Jacobino, Jantine E. Bakema, Deon Kanters, Jan A. M. van der Linden, Madelon Bracke, Leo Koenderman, Jeanette H. W. Leusen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
Fc alpha receptor I
IgA
glycogen synthase kinase-3
Protein Kinase C zeta
fluorescence recovery after photobleaching
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03191/full

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