Furosemide/Non-Steroidal Anti-Inflammatory Drug–Drug Pharmaceutical Solids: Novel Opportunities in Drug Formulation
The design of drug–drug multicomponent pharmaceutical solids is one the latest drug development approaches in the pharmaceutical industry. Its purpose is to modulate the physicochemical properties of active pharmaceutical ingredients (APIs), most of them already existing in the market, achieving imp...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Crystals |
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| Online Access: | https://www.mdpi.com/2073-4352/11/11/1339 |
| _version_ | 1797510708661846016 |
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| author | Francisco Javier Acebedo-Martínez Carolina Alarcón-Payer Lucía Rodríguez-Domingo Alicia Domínguez-Martín Jaime Gómez-Morales Duane Choquesillo-Lazarte |
| author_facet | Francisco Javier Acebedo-Martínez Carolina Alarcón-Payer Lucía Rodríguez-Domingo Alicia Domínguez-Martín Jaime Gómez-Morales Duane Choquesillo-Lazarte |
| author_sort | Francisco Javier Acebedo-Martínez |
| collection | DOAJ |
| description | The design of drug–drug multicomponent pharmaceutical solids is one the latest drug development approaches in the pharmaceutical industry. Its purpose is to modulate the physicochemical properties of active pharmaceutical ingredients (APIs), most of them already existing in the market, achieving improved bioavailability properties, especially on oral administration drugs. In this work, our efforts are focused on the mechanochemical synthesis and thorough solid-state characterization of two drug–drug cocrystals involving furosemide and two different non-steroidal anti-inflammatory drugs (NSAIDs) commonly prescribed together: ethenzamide and piroxicam. Besides powder and single crystal X-ray diffraction, infrared spectroscopy and thermal analysis, stability, and solubility tests were performed on the new solid materials. The aim of this work was evaluating the physicochemical properties of such APIs in the new formulation, which revealed a solubility improvement regarding the NSAIDs but not in furosemide. Further studies need to be carried out to evaluate the drug–drug interaction in the novel multicomponent solids, looking for potential novel therapeutic alternatives. |
| first_indexed | 2024-03-10T05:35:12Z |
| format | Article |
| id | doaj.art-2dbd11e4465a4bdf88ead726879edd45 |
| institution | Directory Open Access Journal |
| issn | 2073-4352 |
| language | English |
| last_indexed | 2024-03-10T05:35:12Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Crystals |
| spelling | doaj.art-2dbd11e4465a4bdf88ead726879edd452023-11-22T22:58:10ZengMDPI AGCrystals2073-43522021-11-011111133910.3390/cryst11111339Furosemide/Non-Steroidal Anti-Inflammatory Drug–Drug Pharmaceutical Solids: Novel Opportunities in Drug FormulationFrancisco Javier Acebedo-Martínez0Carolina Alarcón-Payer1Lucía Rodríguez-Domingo2Alicia Domínguez-Martín3Jaime Gómez-Morales4Duane Choquesillo-Lazarte5Laboratorio de Estudios Cristalográficos, IACT, CSIC-Universidad de Granada, Avda. de las Palmeras 4, 18100 Armilla, SpainServicio de Farmacia, Hospital Universitario Virgen de las Nieves, 18014 Granada, SpainLaboratorio de Estudios Cristalográficos, IACT, CSIC-Universidad de Granada, Avda. de las Palmeras 4, 18100 Armilla, SpainDepartment of Inorganic Chemistry, Faculty of Pharmacy, University of Granada, 18071 Granada, SpainLaboratorio de Estudios Cristalográficos, IACT, CSIC-Universidad de Granada, Avda. de las Palmeras 4, 18100 Armilla, SpainLaboratorio de Estudios Cristalográficos, IACT, CSIC-Universidad de Granada, Avda. de las Palmeras 4, 18100 Armilla, SpainThe design of drug–drug multicomponent pharmaceutical solids is one the latest drug development approaches in the pharmaceutical industry. Its purpose is to modulate the physicochemical properties of active pharmaceutical ingredients (APIs), most of them already existing in the market, achieving improved bioavailability properties, especially on oral administration drugs. In this work, our efforts are focused on the mechanochemical synthesis and thorough solid-state characterization of two drug–drug cocrystals involving furosemide and two different non-steroidal anti-inflammatory drugs (NSAIDs) commonly prescribed together: ethenzamide and piroxicam. Besides powder and single crystal X-ray diffraction, infrared spectroscopy and thermal analysis, stability, and solubility tests were performed on the new solid materials. The aim of this work was evaluating the physicochemical properties of such APIs in the new formulation, which revealed a solubility improvement regarding the NSAIDs but not in furosemide. Further studies need to be carried out to evaluate the drug–drug interaction in the novel multicomponent solids, looking for potential novel therapeutic alternatives.https://www.mdpi.com/2073-4352/11/11/1339drug–drug cocrystalfurosemideethenzamidepiroxicammechanochemical synthesis |
| spellingShingle | Francisco Javier Acebedo-Martínez Carolina Alarcón-Payer Lucía Rodríguez-Domingo Alicia Domínguez-Martín Jaime Gómez-Morales Duane Choquesillo-Lazarte Furosemide/Non-Steroidal Anti-Inflammatory Drug–Drug Pharmaceutical Solids: Novel Opportunities in Drug Formulation Crystals drug–drug cocrystal furosemide ethenzamide piroxicam mechanochemical synthesis |
| title | Furosemide/Non-Steroidal Anti-Inflammatory Drug–Drug Pharmaceutical Solids: Novel Opportunities in Drug Formulation |
| title_full | Furosemide/Non-Steroidal Anti-Inflammatory Drug–Drug Pharmaceutical Solids: Novel Opportunities in Drug Formulation |
| title_fullStr | Furosemide/Non-Steroidal Anti-Inflammatory Drug–Drug Pharmaceutical Solids: Novel Opportunities in Drug Formulation |
| title_full_unstemmed | Furosemide/Non-Steroidal Anti-Inflammatory Drug–Drug Pharmaceutical Solids: Novel Opportunities in Drug Formulation |
| title_short | Furosemide/Non-Steroidal Anti-Inflammatory Drug–Drug Pharmaceutical Solids: Novel Opportunities in Drug Formulation |
| title_sort | furosemide non steroidal anti inflammatory drug drug pharmaceutical solids novel opportunities in drug formulation |
| topic | drug–drug cocrystal furosemide ethenzamide piroxicam mechanochemical synthesis |
| url | https://www.mdpi.com/2073-4352/11/11/1339 |
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