Femtosecond laser manufacturing technology for microstents as innovative medical devices to treat open-angle glaucoma
The increasing trend of minimally invasive therapy methods for widespread diseases in the cardiovascular system, in the field of ophthalmology, ear, nose, and throat medicine, or gynecology, leads to an extensive demand for innovative microdevice manufacturing technologies. Femtosecond (fs)-laser te...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2022-09-01
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| Series: | Current Directions in Biomedical Engineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/cdbme-2022-1151 |
| _version_ | 1811159417940344832 |
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| author | Siewert Stefan Bohne Eric Grossmann Swen Schmidt Wolfram Grabow Niels Stahnke Thomas Guthoff Rudolf Stiehm Michael Schmitz Klaus-Peter |
| author_facet | Siewert Stefan Bohne Eric Grossmann Swen Schmidt Wolfram Grabow Niels Stahnke Thomas Guthoff Rudolf Stiehm Michael Schmitz Klaus-Peter |
| author_sort | Siewert Stefan |
| collection | DOAJ |
| description | The increasing trend of minimally invasive therapy methods for widespread diseases in the cardiovascular system, in the field of ophthalmology, ear, nose, and throat medicine, or gynecology, leads to an extensive demand for innovative microdevice manufacturing technologies. Femtosecond (fs)-laser technology offers a wide range of applications in the field of cutting, milling, and surface structuring on the micro- and nanometer scale. Ophthalmic devices for glaucoma therapy have dimensions in the submillimeter range. Irrespective of this, there are high demands on the safety and efficacy of these implants. Within the current study, fs-laser-based manufacturing technologies for functional elements of a novel microstent for glaucoma therapy were developed, considering potential industrial scalability. We successfully developed a mounting mechanism for quick and reproducible manufacturing of a micromechanical valve mechanism for safe regulation of intraocular pressure. Furthermore, we successfully developed a fs-laser-based process for manufacturing grooves as part of a fixation mechanism for a stable device positioning inside the eye. The results show that fs-laser manufacturing represents a promising technology for manufacturers of medical microdevices, such as ophthalmic microstents. |
| first_indexed | 2024-04-10T05:40:45Z |
| format | Article |
| id | doaj.art-2dbd5a7e286c43db81b9a4079c1bf7be |
| institution | Directory Open Access Journal |
| issn | 2364-5504 |
| language | English |
| last_indexed | 2024-04-10T05:40:45Z |
| publishDate | 2022-09-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Current Directions in Biomedical Engineering |
| spelling | doaj.art-2dbd5a7e286c43db81b9a4079c1bf7be2023-03-06T10:24:52ZengDe GruyterCurrent Directions in Biomedical Engineering2364-55042022-09-018259259510.1515/cdbme-2022-1151Femtosecond laser manufacturing technology for microstents as innovative medical devices to treat open-angle glaucomaSiewert Stefan0Bohne Eric1Grossmann Swen2Schmidt Wolfram3Grabow Niels4Stahnke Thomas5Guthoff Rudolf6Stiehm Michael7Schmitz Klaus-Peter8Institute for ImplantTechnology and Biomaterials e.V., Friedrich- Barnewitz-Str. 4, 18119Rostock-Warnemunde, GermanyInstitute for ImplantTechnology and Biomaterials e.V., Friedrich-Barnewitz-Str. 4, 18119Rostock-Warnemunde, GermanyInstitute for ImplantTechnology and Biomaterials e.V., Friedrich-Barnewitz-Str. 4, 18119Rostock-Warnemunde, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center,Rostock-Warnemunde, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center,Rostock-Warnemunde, GermanyInstitute for ImplantTechnology and Biomaterials e.V., Friedrich-Barnewitz-Str. 4, 18119Rostock-Warnemunde, GermanyDepartment of Ophthalmology, Rostock University Medical Center,Rostock, GermanyInstitute for ImplantTechnology and Biomaterials e.V., Friedrich-Barnewitz-Str. 4, 18119Rostock-Warnemunde, GermanyInstitute for ImplantTechnology and Biomaterials e.V., Friedrich-Barnewitz-Str. 4, 18119Rostock-Warnemunde, GermanyThe increasing trend of minimally invasive therapy methods for widespread diseases in the cardiovascular system, in the field of ophthalmology, ear, nose, and throat medicine, or gynecology, leads to an extensive demand for innovative microdevice manufacturing technologies. Femtosecond (fs)-laser technology offers a wide range of applications in the field of cutting, milling, and surface structuring on the micro- and nanometer scale. Ophthalmic devices for glaucoma therapy have dimensions in the submillimeter range. Irrespective of this, there are high demands on the safety and efficacy of these implants. Within the current study, fs-laser-based manufacturing technologies for functional elements of a novel microstent for glaucoma therapy were developed, considering potential industrial scalability. We successfully developed a mounting mechanism for quick and reproducible manufacturing of a micromechanical valve mechanism for safe regulation of intraocular pressure. Furthermore, we successfully developed a fs-laser-based process for manufacturing grooves as part of a fixation mechanism for a stable device positioning inside the eye. The results show that fs-laser manufacturing represents a promising technology for manufacturers of medical microdevices, such as ophthalmic microstents.https://doi.org/10.1515/cdbme-2022-1151femtosecond laser technologymaterial processingmachiningconstruction methodologymicrostent |
| spellingShingle | Siewert Stefan Bohne Eric Grossmann Swen Schmidt Wolfram Grabow Niels Stahnke Thomas Guthoff Rudolf Stiehm Michael Schmitz Klaus-Peter Femtosecond laser manufacturing technology for microstents as innovative medical devices to treat open-angle glaucoma Current Directions in Biomedical Engineering femtosecond laser technology material processing machining construction methodology microstent |
| title | Femtosecond laser manufacturing technology for microstents as innovative medical devices to treat open-angle glaucoma |
| title_full | Femtosecond laser manufacturing technology for microstents as innovative medical devices to treat open-angle glaucoma |
| title_fullStr | Femtosecond laser manufacturing technology for microstents as innovative medical devices to treat open-angle glaucoma |
| title_full_unstemmed | Femtosecond laser manufacturing technology for microstents as innovative medical devices to treat open-angle glaucoma |
| title_short | Femtosecond laser manufacturing technology for microstents as innovative medical devices to treat open-angle glaucoma |
| title_sort | femtosecond laser manufacturing technology for microstents as innovative medical devices to treat open angle glaucoma |
| topic | femtosecond laser technology material processing machining construction methodology microstent |
| url | https://doi.org/10.1515/cdbme-2022-1151 |
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