Partial Reduction in <i>BRCA1</i> Gene Dose Modulates DNA Replication Stress Level and Thereby Contributes to Sensitivity or Resistance

Partial Reduction in <i>BRCA1</i> Gene Dose Modulates DNA Replication Stress Level and Thereby Contributes to Sensitivity or Resistance

<i>BRCA1</i> is a well-known breast cancer risk gene, involved in DNA damage repair via homologous recombination (HR) and replication fork protection. Therapy resistance was linked to loss and amplification of the <i>BRCA1</i> gene causing inferior survival of breast cancer p...

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Bibliographic Details
Main Authors: Sandra Classen, Elena Rahlf, Johannes Jungwirth, Nina Albers, Luca Philipp Hebestreit, Alexandra Zielinski, Lena Poole, Marco Groth, Philipp Koch, Thomas Liehr, Stefanie Kankel, Nils Cordes, Cordula Petersen, Kai Rothkamm, Helmut Pospiech, Kerstin Borgmann
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
BRCA1
homologous recombination
DNA damage response
CHK1
replication stress
irradiation
Online Access:https://www.mdpi.com/1422-0067/23/21/13363

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