The Release of a Highly Cytotoxic Paullone Bearing a TEMPO Free Radical from the HSA Hydrogel: An EPR Spectroscopic Characterization

The Release of a Highly Cytotoxic Paullone Bearing a TEMPO Free Radical from the HSA Hydrogel: An EPR Spectroscopic Characterization

This study shows the potential of a thermally induced human serum albumin (HSA) hydrogel to serve as a drug depot for sustained release of a highly cytotoxic modified paullone ligand bearing a TEMPO free radical (<b>HL</b>). The binding of <b>HL</b> to HSA was studied by elec...

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Bibliographic Details
Main Authors: Ana Vesković, Đura Nakarada, Olga Vasiljević, Anatolie Dobrov, Gabriella Spengler, Éva A. Enyedy, Vladimir B. Arion, Ana Popović Bijelić
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Pharmaceutics
Subjects:
cytotoxic ligand
drug release
EPR spectroscopy and imaging
HSA hydrogel
paullones
spin labeling
Online Access:https://www.mdpi.com/1999-4923/14/6/1174

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