WFS1 functions in ER export of vesicular cargo proteins in pancreatic β-cells
The role of cargo receptors in proinsulin export from the ER is unclear. Here, the authors identify the WFS1 protein, which is mutated in Wolfram syndrome and associated with diabetes, as an ER to Golgi cargo receptor required for normal insulin processing and secretion.
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-27344-y |
| _version_ | 1818401508747640832 |
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| author | Linlin Wang Hongyang Liu Xiaofei Zhang Eli Song You Wang Tao Xu Zonghong Li |
| author_facet | Linlin Wang Hongyang Liu Xiaofei Zhang Eli Song You Wang Tao Xu Zonghong Li |
| author_sort | Linlin Wang |
| collection | DOAJ |
| description | The role of cargo receptors in proinsulin export from the ER is unclear. Here, the authors identify the WFS1 protein, which is mutated in Wolfram syndrome and associated with diabetes, as an ER to Golgi cargo receptor required for normal insulin processing and secretion. |
| first_indexed | 2024-12-14T07:53:35Z |
| format | Article |
| id | doaj.art-2dbfff4106d24b84a1198b1c6c0b10e8 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T07:53:35Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2dbfff4106d24b84a1198b1c6c0b10e82022-12-21T23:10:36ZengNature PortfolioNature Communications2041-17232021-11-0112111310.1038/s41467-021-27344-yWFS1 functions in ER export of vesicular cargo proteins in pancreatic β-cellsLinlin Wang0Hongyang Liu1Xiaofei Zhang2Eli Song3You Wang4Tao Xu5Zonghong Li6Guangzhou LaboratoryNational Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesCollege of Life Sciences, University of Chinese Academy of SciencesNational Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesNational Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesGuangzhou LaboratoryGuangzhou LaboratoryThe role of cargo receptors in proinsulin export from the ER is unclear. Here, the authors identify the WFS1 protein, which is mutated in Wolfram syndrome and associated with diabetes, as an ER to Golgi cargo receptor required for normal insulin processing and secretion.https://doi.org/10.1038/s41467-021-27344-y |
| spellingShingle | Linlin Wang Hongyang Liu Xiaofei Zhang Eli Song You Wang Tao Xu Zonghong Li WFS1 functions in ER export of vesicular cargo proteins in pancreatic β-cells Nature Communications |
| title | WFS1 functions in ER export of vesicular cargo proteins in pancreatic β-cells |
| title_full | WFS1 functions in ER export of vesicular cargo proteins in pancreatic β-cells |
| title_fullStr | WFS1 functions in ER export of vesicular cargo proteins in pancreatic β-cells |
| title_full_unstemmed | WFS1 functions in ER export of vesicular cargo proteins in pancreatic β-cells |
| title_short | WFS1 functions in ER export of vesicular cargo proteins in pancreatic β-cells |
| title_sort | wfs1 functions in er export of vesicular cargo proteins in pancreatic β cells |
| url | https://doi.org/10.1038/s41467-021-27344-y |
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