Recent advancement in vascularized tissue-engineered bone based on materials design and modification
Bone is one of the most vascular network-rich tissues in the body and the vascular system is essential for the development, homeostasis, and regeneration of bone. When segmental irreversible damage occurs to the bone, restoring its vascular system by means other than autogenous bone grafts with vasc...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
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| Series: | Materials Today Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006423003186 |
| _version_ | 1827728386999451648 |
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| author | Hao Liu Hao Chen Qin Han Bin Sun Yang Liu Aobo Zhang Danyang Fan Peng Xia Jincheng Wang |
| author_facet | Hao Liu Hao Chen Qin Han Bin Sun Yang Liu Aobo Zhang Danyang Fan Peng Xia Jincheng Wang |
| author_sort | Hao Liu |
| collection | DOAJ |
| description | Bone is one of the most vascular network-rich tissues in the body and the vascular system is essential for the development, homeostasis, and regeneration of bone. When segmental irreversible damage occurs to the bone, restoring its vascular system by means other than autogenous bone grafts with vascular pedicles is a therapeutic challenge. By pre-generating the vascular network of the scaffold in vivo or in vitro, the pre-vascularization technique enables an abundant blood supply in the scaffold after implantation. However, pre-vascularization techniques are time-consuming, and in vivo pre-vascularization techniques can be damaging to the body. Critical bone deficiencies may be filled quickly with immediate implantation of a supporting bone tissue engineered scaffold. However, bone tissue engineered scaffolds generally lack vascularization, which requires modification of the scaffold to aid in enhancing internal vascularization. In this review, we summarize the relationship between the vascular system and osteogenesis and use it as a basis to further discuss surgical and cytotechnology-based pre-vascularization strategies and to describe the preparation of vascularized bone tissue engineered scaffolds that can be implanted immediately. We anticipate that this study will serve as inspiration for future vascularized bone tissue engineered scaffold construction and will aid in the achievement of clinical vascularized bone. |
| first_indexed | 2024-03-10T23:29:29Z |
| format | Article |
| id | doaj.art-2dc05993bd1345f39ac84de5653724af |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-03-10T23:29:29Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-2dc05993bd1345f39ac84de5653724af2023-11-19T04:35:23ZengElsevierMaterials Today Bio2590-00642023-12-0123100858Recent advancement in vascularized tissue-engineered bone based on materials design and modificationHao Liu0Hao Chen1Qin Han2Bin Sun3Yang Liu4Aobo Zhang5Danyang Fan6Peng Xia7Jincheng Wang8Department of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun 130000, Jilin, ChinaDepartment of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun 130000, Jilin, ChinaDepartment of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun 130000, Jilin, ChinaDepartment of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun 130000, Jilin, ChinaDepartment of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun 130000, Jilin, ChinaDepartment of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun 130000, Jilin, ChinaDepartment of Dermatology, The Second Hospital of Jilin University, Changchun 130000, Jilin, ChinaDepartment of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun 130000, Jilin, China; Corresponding author.Department of Orthopedic Surgery, The Second Hospital of Jilin University, Changchun 130000, Jilin, ChinaBone is one of the most vascular network-rich tissues in the body and the vascular system is essential for the development, homeostasis, and regeneration of bone. When segmental irreversible damage occurs to the bone, restoring its vascular system by means other than autogenous bone grafts with vascular pedicles is a therapeutic challenge. By pre-generating the vascular network of the scaffold in vivo or in vitro, the pre-vascularization technique enables an abundant blood supply in the scaffold after implantation. However, pre-vascularization techniques are time-consuming, and in vivo pre-vascularization techniques can be damaging to the body. Critical bone deficiencies may be filled quickly with immediate implantation of a supporting bone tissue engineered scaffold. However, bone tissue engineered scaffolds generally lack vascularization, which requires modification of the scaffold to aid in enhancing internal vascularization. In this review, we summarize the relationship between the vascular system and osteogenesis and use it as a basis to further discuss surgical and cytotechnology-based pre-vascularization strategies and to describe the preparation of vascularized bone tissue engineered scaffolds that can be implanted immediately. We anticipate that this study will serve as inspiration for future vascularized bone tissue engineered scaffold construction and will aid in the achievement of clinical vascularized bone.http://www.sciencedirect.com/science/article/pii/S2590006423003186VascularizationBone tissue engineeringPre-vascularizationBiomaterial |
| spellingShingle | Hao Liu Hao Chen Qin Han Bin Sun Yang Liu Aobo Zhang Danyang Fan Peng Xia Jincheng Wang Recent advancement in vascularized tissue-engineered bone based on materials design and modification Materials Today Bio Vascularization Bone tissue engineering Pre-vascularization Biomaterial |
| title | Recent advancement in vascularized tissue-engineered bone based on materials design and modification |
| title_full | Recent advancement in vascularized tissue-engineered bone based on materials design and modification |
| title_fullStr | Recent advancement in vascularized tissue-engineered bone based on materials design and modification |
| title_full_unstemmed | Recent advancement in vascularized tissue-engineered bone based on materials design and modification |
| title_short | Recent advancement in vascularized tissue-engineered bone based on materials design and modification |
| title_sort | recent advancement in vascularized tissue engineered bone based on materials design and modification |
| topic | Vascularization Bone tissue engineering Pre-vascularization Biomaterial |
| url | http://www.sciencedirect.com/science/article/pii/S2590006423003186 |
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