Revealing Prognostic Value of Skeletal-Related Parameters in Metastatic Castration-Resistant Prostate Cancer on Overall Survival: A Systematic Review and Meta-Analysis of Randomized Controlled Trial
BackgroundThe skeleton is a preferred site for prostate cancer metastasis, and once metastases occur, the disease becomes incurable. Increasing evidence indicates the prognostic value of skeletal-related parameters, but remains controversial.ObjectiveTo perform a systematic review of the existing li...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-11-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.586192/full |
| _version_ | 1818192527263531008 |
|---|---|
| author | Tongyu Tong Hanqi Lei Yupeng Guan Xiangwei Yang Guolong Liao Yamei Li Donggen Jiang Jun Pang |
| author_facet | Tongyu Tong Hanqi Lei Yupeng Guan Xiangwei Yang Guolong Liao Yamei Li Donggen Jiang Jun Pang |
| author_sort | Tongyu Tong |
| collection | DOAJ |
| description | BackgroundThe skeleton is a preferred site for prostate cancer metastasis, and once metastases occur, the disease becomes incurable. Increasing evidence indicates the prognostic value of skeletal-related parameters, but remains controversial.ObjectiveTo perform a systematic review of the existing literature on assessing the prognostic value of alkaline phosphatase (ALP), bone-specific alkaline phosphatase (BSAP), urinary N-telopeptide (uNTx), bone scan index (BSI), and Brief Pain Inventory Short Form (BPI-SF) score in castration-resistant prostate cancer (CRPC) patients with skeleton metastasis.Evidence AcquisitionPubMed, Web of Science, Cochrane Library, Medline, OVID, and Embase between 2010 and 2019 were reviewed. Key terms included randomized trials, prostate cancer, alkaline phosphatase, bone-specific alkaline phosphatase, urinary N-telopeptide, bone scan index, and Brief Pain Inventory Short Form. Data were collected, checked, and analyzed from December 2019 to March 2020. Hazard ratios (HRs) and overall survival (OS) were extracted to estimate the relationship between the above parameters and OS in patients with metastatic prostate cancer (mPCa).Evidence SynthesisA total of 1,055 studies were identified via initial screening, including 1,032 from database research and 23 from other sources. After deduplication, 164 records were further excluded according to titles and abstracts. The remaining 36 potential articles were carefully screened. In the end, 15 eligible studies syntheses, which were published between 2010 and 2019, comprised data for a total of 11,378 patients, whose mean age ranged from 66 to 72 years. The sample size ranged from 82 to 1,901 patients. And the median follow-up time ranged from 24 to 55 months. Based on 15 randomized controlled trials published between 2010 and 2019, higher ALP levels (HR = 1.60, 95% CI: 1.38–1.87 P < 0.001), higher BSAP levels (HR = 1.31, 95% CI: 1.11–1.54 P = 0.001), higher uNTx levels (HR = 1.40, 95% CI: 1.29–1.52 P < 0.001), BSI progression (HR = 1.18, 95% CI: 1.08–1.29 P < 0.001), and higher BPI-SF score (HR = 1.47, 95% CI: 1.35–1.61 P < 0.001) had an association with inferior OS.ConclusionsHigher levels of ALP/BSAP and uNTx, a higher BPI-SF score, and progression of BSI predict inferior OS in patients with mCRPC. More randomized control trials are needed to investigate the promising value of these parameters. |
| first_indexed | 2024-12-12T00:31:55Z |
| format | Article |
| id | doaj.art-2dc15afd48bd434493c34da2060c4506 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-12T00:31:55Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-2dc15afd48bd434493c34da2060c45062022-12-22T00:44:27ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-11-011010.3389/fonc.2020.586192586192Revealing Prognostic Value of Skeletal-Related Parameters in Metastatic Castration-Resistant Prostate Cancer on Overall Survival: A Systematic Review and Meta-Analysis of Randomized Controlled TrialTongyu TongHanqi LeiYupeng GuanXiangwei YangGuolong LiaoYamei LiDonggen JiangJun PangBackgroundThe skeleton is a preferred site for prostate cancer metastasis, and once metastases occur, the disease becomes incurable. Increasing evidence indicates the prognostic value of skeletal-related parameters, but remains controversial.ObjectiveTo perform a systematic review of the existing literature on assessing the prognostic value of alkaline phosphatase (ALP), bone-specific alkaline phosphatase (BSAP), urinary N-telopeptide (uNTx), bone scan index (BSI), and Brief Pain Inventory Short Form (BPI-SF) score in castration-resistant prostate cancer (CRPC) patients with skeleton metastasis.Evidence AcquisitionPubMed, Web of Science, Cochrane Library, Medline, OVID, and Embase between 2010 and 2019 were reviewed. Key terms included randomized trials, prostate cancer, alkaline phosphatase, bone-specific alkaline phosphatase, urinary N-telopeptide, bone scan index, and Brief Pain Inventory Short Form. Data were collected, checked, and analyzed from December 2019 to March 2020. Hazard ratios (HRs) and overall survival (OS) were extracted to estimate the relationship between the above parameters and OS in patients with metastatic prostate cancer (mPCa).Evidence SynthesisA total of 1,055 studies were identified via initial screening, including 1,032 from database research and 23 from other sources. After deduplication, 164 records were further excluded according to titles and abstracts. The remaining 36 potential articles were carefully screened. In the end, 15 eligible studies syntheses, which were published between 2010 and 2019, comprised data for a total of 11,378 patients, whose mean age ranged from 66 to 72 years. The sample size ranged from 82 to 1,901 patients. And the median follow-up time ranged from 24 to 55 months. Based on 15 randomized controlled trials published between 2010 and 2019, higher ALP levels (HR = 1.60, 95% CI: 1.38–1.87 P < 0.001), higher BSAP levels (HR = 1.31, 95% CI: 1.11–1.54 P = 0.001), higher uNTx levels (HR = 1.40, 95% CI: 1.29–1.52 P < 0.001), BSI progression (HR = 1.18, 95% CI: 1.08–1.29 P < 0.001), and higher BPI-SF score (HR = 1.47, 95% CI: 1.35–1.61 P < 0.001) had an association with inferior OS.ConclusionsHigher levels of ALP/BSAP and uNTx, a higher BPI-SF score, and progression of BSI predict inferior OS in patients with mCRPC. More randomized control trials are needed to investigate the promising value of these parameters.https://www.frontiersin.org/articles/10.3389/fonc.2020.586192/fullmetastatic castration-resistant prostate cancerskeletal-related parametersoverall survivalprognosismeta-analysis |
| spellingShingle | Tongyu Tong Hanqi Lei Yupeng Guan Xiangwei Yang Guolong Liao Yamei Li Donggen Jiang Jun Pang Revealing Prognostic Value of Skeletal-Related Parameters in Metastatic Castration-Resistant Prostate Cancer on Overall Survival: A Systematic Review and Meta-Analysis of Randomized Controlled Trial Frontiers in Oncology metastatic castration-resistant prostate cancer skeletal-related parameters overall survival prognosis meta-analysis |
| title | Revealing Prognostic Value of Skeletal-Related Parameters in Metastatic Castration-Resistant Prostate Cancer on Overall Survival: A Systematic Review and Meta-Analysis of Randomized Controlled Trial |
| title_full | Revealing Prognostic Value of Skeletal-Related Parameters in Metastatic Castration-Resistant Prostate Cancer on Overall Survival: A Systematic Review and Meta-Analysis of Randomized Controlled Trial |
| title_fullStr | Revealing Prognostic Value of Skeletal-Related Parameters in Metastatic Castration-Resistant Prostate Cancer on Overall Survival: A Systematic Review and Meta-Analysis of Randomized Controlled Trial |
| title_full_unstemmed | Revealing Prognostic Value of Skeletal-Related Parameters in Metastatic Castration-Resistant Prostate Cancer on Overall Survival: A Systematic Review and Meta-Analysis of Randomized Controlled Trial |
| title_short | Revealing Prognostic Value of Skeletal-Related Parameters in Metastatic Castration-Resistant Prostate Cancer on Overall Survival: A Systematic Review and Meta-Analysis of Randomized Controlled Trial |
| title_sort | revealing prognostic value of skeletal related parameters in metastatic castration resistant prostate cancer on overall survival a systematic review and meta analysis of randomized controlled trial |
| topic | metastatic castration-resistant prostate cancer skeletal-related parameters overall survival prognosis meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.586192/full |
| work_keys_str_mv | AT tongyutong revealingprognosticvalueofskeletalrelatedparametersinmetastaticcastrationresistantprostatecanceronoverallsurvivalasystematicreviewandmetaanalysisofrandomizedcontrolledtrial AT hanqilei revealingprognosticvalueofskeletalrelatedparametersinmetastaticcastrationresistantprostatecanceronoverallsurvivalasystematicreviewandmetaanalysisofrandomizedcontrolledtrial AT yupengguan revealingprognosticvalueofskeletalrelatedparametersinmetastaticcastrationresistantprostatecanceronoverallsurvivalasystematicreviewandmetaanalysisofrandomizedcontrolledtrial AT xiangweiyang revealingprognosticvalueofskeletalrelatedparametersinmetastaticcastrationresistantprostatecanceronoverallsurvivalasystematicreviewandmetaanalysisofrandomizedcontrolledtrial AT guolongliao revealingprognosticvalueofskeletalrelatedparametersinmetastaticcastrationresistantprostatecanceronoverallsurvivalasystematicreviewandmetaanalysisofrandomizedcontrolledtrial AT yameili revealingprognosticvalueofskeletalrelatedparametersinmetastaticcastrationresistantprostatecanceronoverallsurvivalasystematicreviewandmetaanalysisofrandomizedcontrolledtrial AT donggenjiang revealingprognosticvalueofskeletalrelatedparametersinmetastaticcastrationresistantprostatecanceronoverallsurvivalasystematicreviewandmetaanalysisofrandomizedcontrolledtrial AT junpang revealingprognosticvalueofskeletalrelatedparametersinmetastaticcastrationresistantprostatecanceronoverallsurvivalasystematicreviewandmetaanalysisofrandomizedcontrolledtrial |