Changes of esophageal varices in hepatitis C patients after achievement of a sustained viral response by direct‐acting antivirals
Abstract Objectives The changes in portal hypertension after achieving a sustained viral response (SVR) by direct‐acting antivirals (DAAs) have not been fully elucidated. Consequently, noninvasive and inexpensive predictors need to be investigated. We therefore explored factors associated with the p...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-04-01
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| Series: | DEN Open |
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| Online Access: | https://doi.org/10.1002/deo2.11 |
| _version_ | 1811312409003950080 |
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| author | Satoshi Takakusagi Naoto Saito Takashi Ueno Takeshi Hatanaka Masashi Namikawa Hiroki Tojima Daichi Takizawa Atsushi Naganuma Takashi Kosone Hirotaka Arai Ken Sato Satoru Kakizaki Hitoshi Takagi Toshio Uraoka |
| author_facet | Satoshi Takakusagi Naoto Saito Takashi Ueno Takeshi Hatanaka Masashi Namikawa Hiroki Tojima Daichi Takizawa Atsushi Naganuma Takashi Kosone Hirotaka Arai Ken Sato Satoru Kakizaki Hitoshi Takagi Toshio Uraoka |
| author_sort | Satoshi Takakusagi |
| collection | DOAJ |
| description | Abstract Objectives The changes in portal hypertension after achieving a sustained viral response (SVR) by direct‐acting antivirals (DAAs) have not been fully elucidated. Consequently, noninvasive and inexpensive predictors need to be investigated. We therefore explored factors associated with the progression of EVs after the achievement of an SVR with DAAs in patients with chronic hepatitis C. Methods Eighty‐nine patients, who had achieved an SVR with DAAs and could have their esophagogastroduodenoscopy (EGD) findings compared between before DAAs administration and after achieving an SVR achievement were enrolled in this study. We compared the patients with and without EVs progression. Furthermore, the cumulative progression rates of EVs were also analyzed. Results The fibrosis‐4 index (FIB‐4) before DAAs administration was the only significant factor for the progression of EVs after an SVR (odds ratios: 1.2, 95% confidence intervals: 1.05–1.38, p = 0.01). In a receiver operating characteristics analysis, the cut‐off of FIB‐4 for the progression of EVs was 8.41 (sensitivity: 0.63, specificity: 0.86, positive predictive value: 0.31, negative predictive value: 0.96), namely EVs of those with more than 8.41 of FIB‐4 progressed and those with less than 8.41 of FIB‐4 did not. Conclusions As patients with FIB‐4 ≥ 8.41 may have progressions of EVs, periodic surveillance by EGD should be continued in such cases, even after an SVR is achieved. |
| first_indexed | 2024-04-13T10:35:43Z |
| format | Article |
| id | doaj.art-2dc4bdfc48e44abda2578cb3c9fdc6f3 |
| institution | Directory Open Access Journal |
| issn | 2692-4609 |
| language | English |
| last_indexed | 2024-04-13T10:35:43Z |
| publishDate | 2022-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | DEN Open |
| spelling | doaj.art-2dc4bdfc48e44abda2578cb3c9fdc6f32022-12-22T02:50:03ZengWileyDEN Open2692-46092022-04-0121n/an/a10.1002/deo2.11Changes of esophageal varices in hepatitis C patients after achievement of a sustained viral response by direct‐acting antiviralsSatoshi Takakusagi0Naoto Saito1Takashi Ueno2Takeshi Hatanaka3Masashi Namikawa4Hiroki Tojima5Daichi Takizawa6Atsushi Naganuma7Takashi Kosone8Hirotaka Arai9Ken Sato10Satoru Kakizaki11Hitoshi Takagi12Toshio Uraoka13Department of Gastroenterology and Hepatology Kusunoki Hospital Gunma JapanDepartment of Gastroenterology Gunma Saiseikai Maebashi Hospital Gunma JapanDepartment of Internal Medicine Isesaki Municipal Hospital Gunma JapanDepartment of Gastroenterology Gunma Saiseikai Maebashi Hospital Gunma JapanDepartment of Internal Medicine Kiryu Kosei General Hospital Gunma JapanDepartment of Gastroenterology and Hepatology Gunma University Graduate School of Medicine Gunma JapanDepartment of Gastroenterology Japanese Red Cross Maebashi Hospital Gunma JapanDepartment of Gastroenterology National Hospital Organization Takasaki General Medical Center Gunma JapanDepartment of Gastroenterology and Hepatology Kusunoki Hospital Gunma JapanDepartment of Gastroenterology Japanese Red Cross Maebashi Hospital Gunma JapanDepartment of Gastroenterology and Hepatology Gunma University Graduate School of Medicine Gunma JapanDepartment of Clinical Research National Hospital Organization Takasaki General Medical Center Gunma JapanDepartment of Gastroenterology and Hepatology Kusunoki Hospital Gunma JapanDepartment of Gastroenterology and Hepatology Gunma University Graduate School of Medicine Gunma JapanAbstract Objectives The changes in portal hypertension after achieving a sustained viral response (SVR) by direct‐acting antivirals (DAAs) have not been fully elucidated. Consequently, noninvasive and inexpensive predictors need to be investigated. We therefore explored factors associated with the progression of EVs after the achievement of an SVR with DAAs in patients with chronic hepatitis C. Methods Eighty‐nine patients, who had achieved an SVR with DAAs and could have their esophagogastroduodenoscopy (EGD) findings compared between before DAAs administration and after achieving an SVR achievement were enrolled in this study. We compared the patients with and without EVs progression. Furthermore, the cumulative progression rates of EVs were also analyzed. Results The fibrosis‐4 index (FIB‐4) before DAAs administration was the only significant factor for the progression of EVs after an SVR (odds ratios: 1.2, 95% confidence intervals: 1.05–1.38, p = 0.01). In a receiver operating characteristics analysis, the cut‐off of FIB‐4 for the progression of EVs was 8.41 (sensitivity: 0.63, specificity: 0.86, positive predictive value: 0.31, negative predictive value: 0.96), namely EVs of those with more than 8.41 of FIB‐4 progressed and those with less than 8.41 of FIB‐4 did not. Conclusions As patients with FIB‐4 ≥ 8.41 may have progressions of EVs, periodic surveillance by EGD should be continued in such cases, even after an SVR is achieved.https://doi.org/10.1002/deo2.11direct acting antiviralsesophageal varicesFIB‐4hepatitis Csustained viral response |
| spellingShingle | Satoshi Takakusagi Naoto Saito Takashi Ueno Takeshi Hatanaka Masashi Namikawa Hiroki Tojima Daichi Takizawa Atsushi Naganuma Takashi Kosone Hirotaka Arai Ken Sato Satoru Kakizaki Hitoshi Takagi Toshio Uraoka Changes of esophageal varices in hepatitis C patients after achievement of a sustained viral response by direct‐acting antivirals DEN Open direct acting antivirals esophageal varices FIB‐4 hepatitis C sustained viral response |
| title | Changes of esophageal varices in hepatitis C patients after achievement of a sustained viral response by direct‐acting antivirals |
| title_full | Changes of esophageal varices in hepatitis C patients after achievement of a sustained viral response by direct‐acting antivirals |
| title_fullStr | Changes of esophageal varices in hepatitis C patients after achievement of a sustained viral response by direct‐acting antivirals |
| title_full_unstemmed | Changes of esophageal varices in hepatitis C patients after achievement of a sustained viral response by direct‐acting antivirals |
| title_short | Changes of esophageal varices in hepatitis C patients after achievement of a sustained viral response by direct‐acting antivirals |
| title_sort | changes of esophageal varices in hepatitis c patients after achievement of a sustained viral response by direct acting antivirals |
| topic | direct acting antivirals esophageal varices FIB‐4 hepatitis C sustained viral response |
| url | https://doi.org/10.1002/deo2.11 |
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