Association of PTTG1 expression with invasiveness of non-functioning pituitary adenomas
Background Pituitary tumor transforming gene 1 (PTTG1), paired-like homeodomain 2 (PITX2), and galectin-3 have been widely studied as predictive biomarkers for various tumors and are involved in tumorigenesis and tumor progression. We evaluated the usefulness of PTTG1, PITX2, and galectin-3 as predi...
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| Format: | Article |
| Language: | English |
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Korean Society of Pathologists & the Korean Society for Cytopathology
2022-01-01
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| Series: | Journal of Pathology and Translational Medicine |
| Subjects: | |
| Online Access: | http://www.jpatholtm.org/upload/pdf/jptm-2021-08-31.pdf |
| _version_ | 1818939557400281088 |
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| author | Su Jung Kum Hye Won Lee Soon Gu Kim Hyungsik Park Ilseon Hwang Sang Pyo Kim |
| author_facet | Su Jung Kum Hye Won Lee Soon Gu Kim Hyungsik Park Ilseon Hwang Sang Pyo Kim |
| author_sort | Su Jung Kum |
| collection | DOAJ |
| description | Background Pituitary tumor transforming gene 1 (PTTG1), paired-like homeodomain 2 (PITX2), and galectin-3 have been widely studied as predictive biomarkers for various tumors and are involved in tumorigenesis and tumor progression. We evaluated the usefulness of PTTG1, PITX2, and galectin-3 as predictive biomarkers for invasive non-functioning pituitary adenomas (NFPAs) by determining the relationship between the expressions of these three proteins and the invasiveness of the NFPAs. We also investigated whether PTTG1, E-cadherin, and Ki-67, which are known to be related to each other, show a correlation with NFPA features. Methods A retrospective study was conducted on 87 patients with NPFAs who underwent surgical removal. The NFPAs were classified into three groups based on magnetic resonance imaging findings of suprasellar extension and cavernous sinus invasion. Immunohistochemical staining for PTTG1, PITX2, galectin-3, E-cadherin, and Ki-67 was performed on tissue microarrays. Results PTTG1 expression showed a statistically significant correlation with the invasiveness of NFPAs, whereas PITX2 and galectin-3 did not have a relationship with the invasiveness of NFPAs. Moreover, there was no association among PTTG1, E-cadherin, and Ki-67 expression. Conclusions PTTG1 has the potential to serve as a predictive biomarker for invasive NFPA. Furthermore, this study may serve as a reference for the development of PTTG1-targeted therapeutic agents. |
| first_indexed | 2024-12-20T06:25:38Z |
| format | Article |
| id | doaj.art-2dc4c833f03c43cb9a9738ac3ee6b5d4 |
| institution | Directory Open Access Journal |
| issn | 2383-7837 2383-7845 |
| language | English |
| last_indexed | 2024-12-20T06:25:38Z |
| publishDate | 2022-01-01 |
| publisher | Korean Society of Pathologists & the Korean Society for Cytopathology |
| record_format | Article |
| series | Journal of Pathology and Translational Medicine |
| spelling | doaj.art-2dc4c833f03c43cb9a9738ac3ee6b5d42022-12-21T19:50:18ZengKorean Society of Pathologists & the Korean Society for CytopathologyJournal of Pathology and Translational Medicine2383-78372383-78452022-01-01561223110.4132/jptm.2021.08.3116996Association of PTTG1 expression with invasiveness of non-functioning pituitary adenomasSu Jung Kum0Hye Won Lee1Soon Gu Kim2Hyungsik Park3Ilseon Hwang4Sang Pyo Kim5Department of Pathology, Keimyung University Dongsan Medical Center, Daegu, KoreaDepartment of Pathology, Keimyung University Dongsan Medical Center, Daegu, KoreaDepartment of Pathology, Keimyung University Dongsan Medical Center, Daegu, KoreaDepartment of Pathology, Keimyung University Dongsan Medical Center, Daegu, KoreaDepartment of Pathology, Keimyung University Dongsan Medical Center, Daegu, KoreaDepartment of Pathology, Keimyung University Dongsan Medical Center, Daegu, KoreaBackground Pituitary tumor transforming gene 1 (PTTG1), paired-like homeodomain 2 (PITX2), and galectin-3 have been widely studied as predictive biomarkers for various tumors and are involved in tumorigenesis and tumor progression. We evaluated the usefulness of PTTG1, PITX2, and galectin-3 as predictive biomarkers for invasive non-functioning pituitary adenomas (NFPAs) by determining the relationship between the expressions of these three proteins and the invasiveness of the NFPAs. We also investigated whether PTTG1, E-cadherin, and Ki-67, which are known to be related to each other, show a correlation with NFPA features. Methods A retrospective study was conducted on 87 patients with NPFAs who underwent surgical removal. The NFPAs were classified into three groups based on magnetic resonance imaging findings of suprasellar extension and cavernous sinus invasion. Immunohistochemical staining for PTTG1, PITX2, galectin-3, E-cadherin, and Ki-67 was performed on tissue microarrays. Results PTTG1 expression showed a statistically significant correlation with the invasiveness of NFPAs, whereas PITX2 and galectin-3 did not have a relationship with the invasiveness of NFPAs. Moreover, there was no association among PTTG1, E-cadherin, and Ki-67 expression. Conclusions PTTG1 has the potential to serve as a predictive biomarker for invasive NFPA. Furthermore, this study may serve as a reference for the development of PTTG1-targeted therapeutic agents.http://www.jpatholtm.org/upload/pdf/jptm-2021-08-31.pdfnon-functioning pituitary adenomaspituitary tumor transforming gene expressioninvasiveness |
| spellingShingle | Su Jung Kum Hye Won Lee Soon Gu Kim Hyungsik Park Ilseon Hwang Sang Pyo Kim Association of PTTG1 expression with invasiveness of non-functioning pituitary adenomas Journal of Pathology and Translational Medicine non-functioning pituitary adenomas pituitary tumor transforming gene expression invasiveness |
| title | Association of PTTG1 expression with invasiveness of non-functioning pituitary adenomas |
| title_full | Association of PTTG1 expression with invasiveness of non-functioning pituitary adenomas |
| title_fullStr | Association of PTTG1 expression with invasiveness of non-functioning pituitary adenomas |
| title_full_unstemmed | Association of PTTG1 expression with invasiveness of non-functioning pituitary adenomas |
| title_short | Association of PTTG1 expression with invasiveness of non-functioning pituitary adenomas |
| title_sort | association of pttg1 expression with invasiveness of non functioning pituitary adenomas |
| topic | non-functioning pituitary adenomas pituitary tumor transforming gene expression invasiveness |
| url | http://www.jpatholtm.org/upload/pdf/jptm-2021-08-31.pdf |
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