Prognostic Role and Clinical Significance of Tumor-Infiltrating Lymphocyte (TIL) and Programmed Death Ligand 1 (PD-L1) Expression in Triple-Negative Breast Cancer (TNBC): A Systematic Review and Meta-Analysis Study
This meta-analysis aimed to evaluate the prognostic value of tumor-infiltrating lymphocytes (TILs) and programmed death-ligand 1 (PD-L1), their associations with the clinicopathological characteristics, and the association between their levels in patients with triple-negative breast cancer (TNBC). P...
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| Format: | Article |
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MDPI AG
2020-09-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/10/9/704 |
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| author | Parisa Lotfinejad Mohammad Asghari Jafarabadi Mahdi Abdoli Shadbad Tohid Kazemi Fariba Pashazadeh Siamak Sandoghchian Shotorbani Farhad Jadidi Niaragh Amir Baghbanzadeh Nafiseh Vahed Nicola Silvestris Behzad Baradaran |
| author_facet | Parisa Lotfinejad Mohammad Asghari Jafarabadi Mahdi Abdoli Shadbad Tohid Kazemi Fariba Pashazadeh Siamak Sandoghchian Shotorbani Farhad Jadidi Niaragh Amir Baghbanzadeh Nafiseh Vahed Nicola Silvestris Behzad Baradaran |
| author_sort | Parisa Lotfinejad |
| collection | DOAJ |
| description | This meta-analysis aimed to evaluate the prognostic value of tumor-infiltrating lymphocytes (TILs) and programmed death-ligand 1 (PD-L1), their associations with the clinicopathological characteristics, and the association between their levels in patients with triple-negative breast cancer (TNBC). PubMed, EMBASE, Scopus, ProQuest, Web of Science, and Cochrane Library databases were searched to obtain the relevant papers. Seven studies with 1152 patients were included in this study. Like the level of TILs, there were no significant associations between PD-L1 expression and tumor size, tumor stage, lymph node metastasis, histological grade, and Ki67 (All <i>p</i>-values ≥ 0.05). Furthermore, there was no significant association between PD-L1 expression with overall survival (OS) and disease-free survival (DFS). In assessment of TILs and survival relationship, the results showed that a high level of TILs was associated with long-term OS (hazard ratios (HR) = 0.48, 95% CI: 0.30 to 0.77, <i>p</i>-value < 0.001) and DFS (HR = 0.53, 95% CI: 0.35 to 0.78, <i>p</i>-value < 0.001). The results displayed that tumoral PD-L1 expression was strongly associated with high levels of TILs in TNBC patients (OR = 8.34, 95% CI: 2.68 to 25.95, <i>p</i>-value < 0.001). In conclusion, the study has shown the prognostic value of TILs and a strong association between tumoral PD-L1 overexpression with TILs in TNBC patients. |
| first_indexed | 2024-03-10T16:15:24Z |
| format | Article |
| id | doaj.art-2dc4ca6fec704a6e9fe2610b1a6a36a3 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T16:15:24Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-2dc4ca6fec704a6e9fe2610b1a6a36a32023-11-20T14:04:22ZengMDPI AGDiagnostics2075-44182020-09-0110970410.3390/diagnostics10090704Prognostic Role and Clinical Significance of Tumor-Infiltrating Lymphocyte (TIL) and Programmed Death Ligand 1 (PD-L1) Expression in Triple-Negative Breast Cancer (TNBC): A Systematic Review and Meta-Analysis StudyParisa Lotfinejad0Mohammad Asghari Jafarabadi1Mahdi Abdoli Shadbad2Tohid Kazemi3Fariba Pashazadeh4Siamak Sandoghchian Shotorbani5Farhad Jadidi Niaragh6Amir Baghbanzadeh7Nafiseh Vahed8Nicola Silvestris9Behzad Baradaran10Research Center for Evidence-Based Medicine, Tabriz University of Medical Sciences, Tabriz 5166614766, IranDepartment of Statistics and Epidemiology, Faculty of Health, Tabriz University of Medical Sciences, Tabriz 5165665931, IranImmunology Research Center, Tabriz University of Medical Sciences, Tabriz 5165665811, IranDepartment of Immunology, Tabriz University of Medical Sciences, Tabriz 5166614766, IranResearch Center for Evidence-Based Medicine, Tabriz University of Medical Sciences, Tabriz 5166614766, IranDepartment of Immunology, Tabriz University of Medical Sciences, Tabriz 5166614766, IranDepartment of Immunology, Tabriz University of Medical Sciences, Tabriz 5166614766, IranImmunology Research Center, Tabriz University of Medical Sciences, Tabriz 5165665811, IranEmergency Medicine Research Team, Tabriz University of Medical Sciences, Tabriz 5166614766, IranMedical Oncology Unit, IRCCS Istituto Tumori “Giovanni Paolo II” of Bari, 70124 Bari, ItalyImmunology Research Center, Tabriz University of Medical Sciences, Tabriz 5165665811, IranThis meta-analysis aimed to evaluate the prognostic value of tumor-infiltrating lymphocytes (TILs) and programmed death-ligand 1 (PD-L1), their associations with the clinicopathological characteristics, and the association between their levels in patients with triple-negative breast cancer (TNBC). PubMed, EMBASE, Scopus, ProQuest, Web of Science, and Cochrane Library databases were searched to obtain the relevant papers. Seven studies with 1152 patients were included in this study. Like the level of TILs, there were no significant associations between PD-L1 expression and tumor size, tumor stage, lymph node metastasis, histological grade, and Ki67 (All <i>p</i>-values ≥ 0.05). Furthermore, there was no significant association between PD-L1 expression with overall survival (OS) and disease-free survival (DFS). In assessment of TILs and survival relationship, the results showed that a high level of TILs was associated with long-term OS (hazard ratios (HR) = 0.48, 95% CI: 0.30 to 0.77, <i>p</i>-value < 0.001) and DFS (HR = 0.53, 95% CI: 0.35 to 0.78, <i>p</i>-value < 0.001). The results displayed that tumoral PD-L1 expression was strongly associated with high levels of TILs in TNBC patients (OR = 8.34, 95% CI: 2.68 to 25.95, <i>p</i>-value < 0.001). In conclusion, the study has shown the prognostic value of TILs and a strong association between tumoral PD-L1 overexpression with TILs in TNBC patients.https://www.mdpi.com/2075-4418/10/9/704programmed cell death-ligand 1tumor-infiltrating lymphocytestriple-negative breast cancerprognosismeta-analysis |
| spellingShingle | Parisa Lotfinejad Mohammad Asghari Jafarabadi Mahdi Abdoli Shadbad Tohid Kazemi Fariba Pashazadeh Siamak Sandoghchian Shotorbani Farhad Jadidi Niaragh Amir Baghbanzadeh Nafiseh Vahed Nicola Silvestris Behzad Baradaran Prognostic Role and Clinical Significance of Tumor-Infiltrating Lymphocyte (TIL) and Programmed Death Ligand 1 (PD-L1) Expression in Triple-Negative Breast Cancer (TNBC): A Systematic Review and Meta-Analysis Study Diagnostics programmed cell death-ligand 1 tumor-infiltrating lymphocytes triple-negative breast cancer prognosis meta-analysis |
| title | Prognostic Role and Clinical Significance of Tumor-Infiltrating Lymphocyte (TIL) and Programmed Death Ligand 1 (PD-L1) Expression in Triple-Negative Breast Cancer (TNBC): A Systematic Review and Meta-Analysis Study |
| title_full | Prognostic Role and Clinical Significance of Tumor-Infiltrating Lymphocyte (TIL) and Programmed Death Ligand 1 (PD-L1) Expression in Triple-Negative Breast Cancer (TNBC): A Systematic Review and Meta-Analysis Study |
| title_fullStr | Prognostic Role and Clinical Significance of Tumor-Infiltrating Lymphocyte (TIL) and Programmed Death Ligand 1 (PD-L1) Expression in Triple-Negative Breast Cancer (TNBC): A Systematic Review and Meta-Analysis Study |
| title_full_unstemmed | Prognostic Role and Clinical Significance of Tumor-Infiltrating Lymphocyte (TIL) and Programmed Death Ligand 1 (PD-L1) Expression in Triple-Negative Breast Cancer (TNBC): A Systematic Review and Meta-Analysis Study |
| title_short | Prognostic Role and Clinical Significance of Tumor-Infiltrating Lymphocyte (TIL) and Programmed Death Ligand 1 (PD-L1) Expression in Triple-Negative Breast Cancer (TNBC): A Systematic Review and Meta-Analysis Study |
| title_sort | prognostic role and clinical significance of tumor infiltrating lymphocyte til and programmed death ligand 1 pd l1 expression in triple negative breast cancer tnbc a systematic review and meta analysis study |
| topic | programmed cell death-ligand 1 tumor-infiltrating lymphocytes triple-negative breast cancer prognosis meta-analysis |
| url | https://www.mdpi.com/2075-4418/10/9/704 |
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