Progress of potential drugs targeted in lipid metabolism research
Lipids are a class of complex hydrophobic molecules derived from fatty acids that not only form the structural basis of biological membranes but also regulate metabolism and maintain energy balance. The role of lipids in obesity and other metabolic diseases has recently received much attention, maki...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-12-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.1067652/full |
| _version_ | 1797980721896226816 |
|---|---|
| author | Kai Liang Jian-Ye Dai Jian-Ye Dai |
| author_facet | Kai Liang Jian-Ye Dai Jian-Ye Dai |
| author_sort | Kai Liang |
| collection | DOAJ |
| description | Lipids are a class of complex hydrophobic molecules derived from fatty acids that not only form the structural basis of biological membranes but also regulate metabolism and maintain energy balance. The role of lipids in obesity and other metabolic diseases has recently received much attention, making lipid metabolism one of the attractive research areas. Several metabolic diseases are linked to lipid metabolism, including diabetes, obesity, and atherosclerosis. Additionally, lipid metabolism contributes to the rapid growth of cancer cells as abnormal lipid synthesis or uptake enhances the growth of cancer cells. This review introduces the potential drug targets in lipid metabolism and summarizes the important potential drug targets with recent research progress on the corresponding small molecule inhibitor drugs. The significance of this review is to provide a reference for the clinical treatment of metabolic diseases related to lipid metabolism and the treatment of tumors, hoping to deepen the understanding of lipid metabolism and health. |
| first_indexed | 2024-04-11T05:58:22Z |
| format | Article |
| id | doaj.art-2dc5efb9f9374170ae2706ba9dd220f0 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-11T05:58:22Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-2dc5efb9f9374170ae2706ba9dd220f02022-12-22T04:41:48ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-12-011310.3389/fphar.2022.10676521067652Progress of potential drugs targeted in lipid metabolism researchKai Liang0Jian-Ye Dai1Jian-Ye Dai2School of Life Science, Peking University, Beijing, ChinaSchool of Pharmacy, Lanzhou University, Lanzhou, ChinaCollaborative Innovation Center for Northwestern Chinese Medicine, Lanzhou University, Lanzhou, ChinaLipids are a class of complex hydrophobic molecules derived from fatty acids that not only form the structural basis of biological membranes but also regulate metabolism and maintain energy balance. The role of lipids in obesity and other metabolic diseases has recently received much attention, making lipid metabolism one of the attractive research areas. Several metabolic diseases are linked to lipid metabolism, including diabetes, obesity, and atherosclerosis. Additionally, lipid metabolism contributes to the rapid growth of cancer cells as abnormal lipid synthesis or uptake enhances the growth of cancer cells. This review introduces the potential drug targets in lipid metabolism and summarizes the important potential drug targets with recent research progress on the corresponding small molecule inhibitor drugs. The significance of this review is to provide a reference for the clinical treatment of metabolic diseases related to lipid metabolism and the treatment of tumors, hoping to deepen the understanding of lipid metabolism and health.https://www.frontiersin.org/articles/10.3389/fphar.2022.1067652/fulllipid metabolismfatty acidsmall molecule inhibitormetabolic diseasecancer |
| spellingShingle | Kai Liang Jian-Ye Dai Jian-Ye Dai Progress of potential drugs targeted in lipid metabolism research Frontiers in Pharmacology lipid metabolism fatty acid small molecule inhibitor metabolic disease cancer |
| title | Progress of potential drugs targeted in lipid metabolism research |
| title_full | Progress of potential drugs targeted in lipid metabolism research |
| title_fullStr | Progress of potential drugs targeted in lipid metabolism research |
| title_full_unstemmed | Progress of potential drugs targeted in lipid metabolism research |
| title_short | Progress of potential drugs targeted in lipid metabolism research |
| title_sort | progress of potential drugs targeted in lipid metabolism research |
| topic | lipid metabolism fatty acid small molecule inhibitor metabolic disease cancer |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.1067652/full |
| work_keys_str_mv | AT kailiang progressofpotentialdrugstargetedinlipidmetabolismresearch AT jianyedai progressofpotentialdrugstargetedinlipidmetabolismresearch AT jianyedai progressofpotentialdrugstargetedinlipidmetabolismresearch |