Incidence of community acquired lower respiratory tract disease in Bristol, UK during the COVID-19 pandemic: A prospective cohort study
Summary: Background: The emergence of COVID-19 and public health measures implemented to reduce SARS-CoV-2 infections have both affected acute lower respiratory tract disease (aLRTD) epidemiology and incidence trends. The severity of COVID-19 and non-SARS-CoV-2 aLRTD during this period have not bee...
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-10-01
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| Series: | The Lancet Regional Health. Europe |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666776222001697 |
| _version_ | 1828149677490438144 |
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| author | Catherine Hyams Robert Challen Elizabeth Begier Jo Southern Jade King Anna Morley Zsuzsa Szasz-Benczur Maria Garcia Gonzalez Jane Kinney James Campling Sharon Gray Jennifer Oliver Robin Hubler Srinivas Valluri Andrew Vyse John M. McLaughlin Gillian Ellsbury Nick A. Maskell Bradford D. Gessner Leon Danon Adam Finn Amelia Langdon Anabella Turner Anya Mattocks Bethany Osborne Charli Grimes Claire Mitchell David Adegbite Emma Bridgeman Emma Scott Fiona Perkins Francesca Bayley Gabriella Ruffino Gabriella Valentine Grace Tilzey Johanna Kellett Wright Julia Brzezinska Julie Cloake Katarina Milutinovic Kate Helliker Katie Maughan Kazminder Fox Konstantina Minou Lana Ward Leah Fleming Leigh Morrison Lily Smart Louise Wright Lucy Grimwood Maddalena Bellavia Madeleine Clout Marianne Vasquez Milo Jeenes-Flanagan Natalie Chang Niall Grace Nicola Manning Oliver Griffiths Pip Croxford Peter Sequenza Rajeka Lazarus Rhian Walters Robin Marlow Robyn Heath Rupert Antico Sandi Nammuni Arachchge Seevakumar Suppiah Taslima Mona Tawassal Riaz Vicki Mackay Zandile Maseko Zoe Taylor Zsolt Friedrich |
| author_facet | Catherine Hyams Robert Challen Elizabeth Begier Jo Southern Jade King Anna Morley Zsuzsa Szasz-Benczur Maria Garcia Gonzalez Jane Kinney James Campling Sharon Gray Jennifer Oliver Robin Hubler Srinivas Valluri Andrew Vyse John M. McLaughlin Gillian Ellsbury Nick A. Maskell Bradford D. Gessner Leon Danon Adam Finn Amelia Langdon Anabella Turner Anya Mattocks Bethany Osborne Charli Grimes Claire Mitchell David Adegbite Emma Bridgeman Emma Scott Fiona Perkins Francesca Bayley Gabriella Ruffino Gabriella Valentine Grace Tilzey Johanna Kellett Wright Julia Brzezinska Julie Cloake Katarina Milutinovic Kate Helliker Katie Maughan Kazminder Fox Konstantina Minou Lana Ward Leah Fleming Leigh Morrison Lily Smart Louise Wright Lucy Grimwood Maddalena Bellavia Madeleine Clout Marianne Vasquez Milo Jeenes-Flanagan Natalie Chang Niall Grace Nicola Manning Oliver Griffiths Pip Croxford Peter Sequenza Rajeka Lazarus Rhian Walters Robin Marlow Robyn Heath Rupert Antico Sandi Nammuni Arachchge Seevakumar Suppiah Taslima Mona Tawassal Riaz Vicki Mackay Zandile Maseko Zoe Taylor Zsolt Friedrich |
| author_sort | Catherine Hyams |
| collection | DOAJ |
| description | Summary: Background: The emergence of COVID-19 and public health measures implemented to reduce SARS-CoV-2 infections have both affected acute lower respiratory tract disease (aLRTD) epidemiology and incidence trends. The severity of COVID-19 and non-SARS-CoV-2 aLRTD during this period have not been compared in detail. Methods: We conducted a prospective cohort study of adults age ≥18 years admitted to either of two acute care hospitals in Bristol, UK, from August 2020 to November 2021. Patients were included if they presented with signs or symptoms of aLRTD (e.g., cough, pleurisy), or a clinical or radiological aLRTD diagnosis. Findings: 12,557 adult aLRTD hospitalisations occurred: 10,087 were associated with infection (pneumonia or non-pneumonic lower respiratory tract infection [NP-LRTI]), 2161 with no infective cause, with 306 providing a minimal surveillance dataset. Confirmed SARS-CoV-2 infection accounted for 32% (3178/10,087) of respiratory infections. Annual incidences of overall, COVID-19, and non- SARS-CoV-2 pneumonia were 714.1, 264.2, and 449.9, and NP-LRTI were 346.2, 43.8, and 302.4 per 100,000 adults, respectively. Weekly incidence trends in COVID-19 aLRTD showed large surges (median 6.5 [IQR 0.7–10.2] admissions per 100,000 adults per week), while other infective aLRTD events were more stable (median 14.3 [IQR 12.8–16.4] admissions per 100,000 adults per week) as were non-infective aLRTD events (median 4.4 [IQR 3.5–5.5] admissions per 100,000 adults per week). Interpretation: While COVID-19 disease was a large component of total aLRTD during this pandemic period, non- SARS-CoV-2 infection still caused the majority of respiratory infection hospitalisations. COVID-19 disease showed significant temporal fluctuations in frequency, which were less apparent in non-SARS-CoV-2 infection. Despite public health interventions to reduce respiratory infection, disease incidence remains high. Funding: AvonCAP is an investigator-led project funded under a collaborative agreement by Pfizer. |
| first_indexed | 2024-04-11T21:33:45Z |
| format | Article |
| id | doaj.art-2dc6ac7e11b84a43aec5b94d55c81b3f |
| institution | Directory Open Access Journal |
| issn | 2666-7762 |
| language | English |
| last_indexed | 2024-04-11T21:33:45Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Lancet Regional Health. Europe |
| spelling | doaj.art-2dc6ac7e11b84a43aec5b94d55c81b3f2022-12-22T04:01:50ZengElsevierThe Lancet Regional Health. Europe2666-77622022-10-0121100473Incidence of community acquired lower respiratory tract disease in Bristol, UK during the COVID-19 pandemic: A prospective cohort studyCatherine Hyams0Robert Challen1Elizabeth Begier2Jo Southern3Jade King4Anna Morley5Zsuzsa Szasz-Benczur6Maria Garcia Gonzalez7Jane Kinney8James Campling9Sharon Gray10Jennifer Oliver11Robin Hubler12Srinivas Valluri13Andrew Vyse14John M. McLaughlin15Gillian Ellsbury16Nick A. Maskell17Bradford D. Gessner18Leon Danon19Adam Finn20Amelia LangdonAnabella TurnerAnya MattocksBethany OsborneCharli GrimesClaire MitchellDavid AdegbiteEmma BridgemanEmma ScottFiona PerkinsFrancesca BayleyGabriella RuffinoGabriella ValentineGrace TilzeyJohanna Kellett WrightJulia BrzezinskaJulie CloakeKatarina MilutinovicKate HellikerKatie MaughanKazminder FoxKonstantina MinouLana WardLeah FlemingLeigh MorrisonLily SmartLouise WrightLucy GrimwoodMaddalena BellaviaMadeleine CloutMarianne VasquezMilo Jeenes-FlanaganNatalie ChangNiall GraceNicola ManningOliver GriffithsPip CroxfordPeter SequenzaRajeka LazarusRhian WaltersRobin MarlowRobyn HeathRupert AnticoSandi Nammuni ArachchgeSeevakumar SuppiahTaslima MonaTawassal RiazVicki MackayZandile MasekoZoe TaylorZsolt FriedrichBristol Vaccine Centre, Population Health Sciences, University of Bristol, UK; Academic Respiratory Unit, University of Bristol, UKEngineering Mathematics, University of Bristol, UKGlobal Medical Development Scientific and Clinical Affairs, Pfizer Vaccines, IrelandVaccines Medical Affairs, Pfizer Ltd, Tadworth KT20 7NS, UKClinical Research and Imaging Centre, UHBW NHS Trust, Bristol, UKAcademic Respiratory Unit, University of Bristol, UKBristol Vaccine Centre, Population Health Sciences, University of Bristol, UKBristol Vaccine Centre, Population Health Sciences, University of Bristol, UKBristol Vaccine Centre, Population Health Sciences, University of Bristol, UKVaccines Medical Affairs, Pfizer Ltd, Tadworth KT20 7NS, UKVaccines Medical Development, Scientific and Clinical Affairs, Pfizer Inc, Collegeville, PA, USAVaccines Medical Affairs, Pfizer Ltd, Tadworth KT20 7NS, UKVaccines Medical Development, Scientific and Clinical Affairs, Pfizer Inc, Collegeville, PA, USAVaccines Medical Development, Scientific and Clinical Affairs, Pfizer Inc, Collegeville, PA, USAVaccines Medical Affairs, Pfizer Ltd, Tadworth KT20 7NS, UKVaccines Medical Development, Scientific and Clinical Affairs, Pfizer Inc, Collegeville, PA, USAVaccines Medical Affairs, Pfizer Ltd, Tadworth KT20 7NS, UKAcademic Respiratory Unit, University of Bristol, UKVaccines Medical Development, Scientific and Clinical Affairs, Pfizer Inc, Collegeville, PA, USAEngineering Mathematics, University of Bristol, UKBristol Vaccine Centre, Population Health Sciences, University of Bristol, UK; Corresponding author at: Bristol Vaccine Centre, University of Bristol, Level 6, UHB Education and Research Centre, Upper Maudlin Street, Bristol BS2 8AE, United Kingdom.Summary: Background: The emergence of COVID-19 and public health measures implemented to reduce SARS-CoV-2 infections have both affected acute lower respiratory tract disease (aLRTD) epidemiology and incidence trends. The severity of COVID-19 and non-SARS-CoV-2 aLRTD during this period have not been compared in detail. Methods: We conducted a prospective cohort study of adults age ≥18 years admitted to either of two acute care hospitals in Bristol, UK, from August 2020 to November 2021. Patients were included if they presented with signs or symptoms of aLRTD (e.g., cough, pleurisy), or a clinical or radiological aLRTD diagnosis. Findings: 12,557 adult aLRTD hospitalisations occurred: 10,087 were associated with infection (pneumonia or non-pneumonic lower respiratory tract infection [NP-LRTI]), 2161 with no infective cause, with 306 providing a minimal surveillance dataset. Confirmed SARS-CoV-2 infection accounted for 32% (3178/10,087) of respiratory infections. Annual incidences of overall, COVID-19, and non- SARS-CoV-2 pneumonia were 714.1, 264.2, and 449.9, and NP-LRTI were 346.2, 43.8, and 302.4 per 100,000 adults, respectively. Weekly incidence trends in COVID-19 aLRTD showed large surges (median 6.5 [IQR 0.7–10.2] admissions per 100,000 adults per week), while other infective aLRTD events were more stable (median 14.3 [IQR 12.8–16.4] admissions per 100,000 adults per week) as were non-infective aLRTD events (median 4.4 [IQR 3.5–5.5] admissions per 100,000 adults per week). Interpretation: While COVID-19 disease was a large component of total aLRTD during this pandemic period, non- SARS-CoV-2 infection still caused the majority of respiratory infection hospitalisations. COVID-19 disease showed significant temporal fluctuations in frequency, which were less apparent in non-SARS-CoV-2 infection. Despite public health interventions to reduce respiratory infection, disease incidence remains high. Funding: AvonCAP is an investigator-led project funded under a collaborative agreement by Pfizer.http://www.sciencedirect.com/science/article/pii/S2666776222001697PneumoniaLower respiratory tract infectionCardiac failureCOVID-19SARS-CoV-2 |
| spellingShingle | Catherine Hyams Robert Challen Elizabeth Begier Jo Southern Jade King Anna Morley Zsuzsa Szasz-Benczur Maria Garcia Gonzalez Jane Kinney James Campling Sharon Gray Jennifer Oliver Robin Hubler Srinivas Valluri Andrew Vyse John M. McLaughlin Gillian Ellsbury Nick A. Maskell Bradford D. Gessner Leon Danon Adam Finn Amelia Langdon Anabella Turner Anya Mattocks Bethany Osborne Charli Grimes Claire Mitchell David Adegbite Emma Bridgeman Emma Scott Fiona Perkins Francesca Bayley Gabriella Ruffino Gabriella Valentine Grace Tilzey Johanna Kellett Wright Julia Brzezinska Julie Cloake Katarina Milutinovic Kate Helliker Katie Maughan Kazminder Fox Konstantina Minou Lana Ward Leah Fleming Leigh Morrison Lily Smart Louise Wright Lucy Grimwood Maddalena Bellavia Madeleine Clout Marianne Vasquez Milo Jeenes-Flanagan Natalie Chang Niall Grace Nicola Manning Oliver Griffiths Pip Croxford Peter Sequenza Rajeka Lazarus Rhian Walters Robin Marlow Robyn Heath Rupert Antico Sandi Nammuni Arachchge Seevakumar Suppiah Taslima Mona Tawassal Riaz Vicki Mackay Zandile Maseko Zoe Taylor Zsolt Friedrich Incidence of community acquired lower respiratory tract disease in Bristol, UK during the COVID-19 pandemic: A prospective cohort study The Lancet Regional Health. Europe Pneumonia Lower respiratory tract infection Cardiac failure COVID-19 SARS-CoV-2 |
| title | Incidence of community acquired lower respiratory tract disease in Bristol, UK during the COVID-19 pandemic: A prospective cohort study |
| title_full | Incidence of community acquired lower respiratory tract disease in Bristol, UK during the COVID-19 pandemic: A prospective cohort study |
| title_fullStr | Incidence of community acquired lower respiratory tract disease in Bristol, UK during the COVID-19 pandemic: A prospective cohort study |
| title_full_unstemmed | Incidence of community acquired lower respiratory tract disease in Bristol, UK during the COVID-19 pandemic: A prospective cohort study |
| title_short | Incidence of community acquired lower respiratory tract disease in Bristol, UK during the COVID-19 pandemic: A prospective cohort study |
| title_sort | incidence of community acquired lower respiratory tract disease in bristol uk during the covid 19 pandemic a prospective cohort study |
| topic | Pneumonia Lower respiratory tract infection Cardiac failure COVID-19 SARS-CoV-2 |
| url | http://www.sciencedirect.com/science/article/pii/S2666776222001697 |
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