Mutations in the Methyltransferase Motifs of L Protein Attenuate Newcastle Disease Virus by Regulating Viral Translation and Cell-to-Cell Spread

Mutations in the Methyltransferase Motifs of L Protein Attenuate Newcastle Disease Virus by Regulating Viral Translation and Cell-to-Cell Spread

ABSTRACT The large (L) polymerase proteins of most nonsegmented, negative-stranded (NNS) RNA viruses have conserved methyltransferase motifs, (G)-G-G-D and K-D-K-E, which are important for the stabilization and translation of mRNA. However, the function of the (G)-G-G-D and K-D-K-E motifs in the NNS...

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Bibliographic Details
Main Authors: Xiao Li, Lu Sun, Jing Zhao, Kaihang Tu, Jia Xue, Xin Guo, Guozhong Zhang
Format: Article
Language:English
Published: American Society for Microbiology 2021-10-01
Series:Microbiology Spectrum
Subjects:
Newcastle disease virus
negative-stranded RNA virus
large polymerase protein
K-D-K-E motif
viral translation
cell-to-cell spread
Online Access:https://journals.asm.org/doi/10.1128/Spectrum.01312-21

Internet

https://journals.asm.org/doi/10.1128/Spectrum.01312-21

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