| Summary: | Cardiac dysfunction accelerates the risk of heart failure, and its pathogenesis involves a complex interaction between genetic and environmental factors. Variations in myosin affect contractile abilities of cardiomyocytes and cause structural and functional abnormalities in myocardium. The study aims to find the association of <i>MYH7</i> rs121913642 (c.1594 T>C) and rs121913645 (c.667G>A) variants with cardiac dysfunction in the Punjabi Pakistani population. Patients with heart failure (<i>n</i> = 232) and healthy controls (<i>n</i> = 205) were enrolled in this study. <i>MYH7</i> variant genotyping was performed using tetra ARMS-PCR. <i>MYH7</i> rs121913642 TC genotype was significantly more prevalent in the patient group (<i>p</i> < 0.001). However, <i>MYH7</i> rs121913645 genotype frequencies were not significantly different between the patient and control groups (<i>p</i> < 0.666). Regression analysis also revealed that the rs121913642 C allele increases the risk of cardiac failure by ~2 [OR:1.98, CI: 1.31–2.98, <i>p</i> < 0.001] in comparison to the T allele. High levels of the cardiac enzymes cardiac troponin I (cTnI) and CK-MB were observed in patients. There was also an increase in total cholesterol, LDL cholesterol, and uric acid in patients compared to the healthy control group (<i>p</i> < 0.001). In conclusion, the <i>MYH7</i> gene variant rs121913642 is genetically associated with cardiac dysfunction and involved in the pathogenesis of HF.
|
|---|