Type 2 Diabetes Prevention Focused on Normalization of Glycemia: A Two-Year Pilot Study
The purpose of this study is to assess the effects of an alternative approach to type 2 diabetes prevention. Ninety-six patients with prediabetes (age 52 (10) years; 80% female; BMI 39.2 (7.1) kg/m<sup>2</sup>) received a continuous remote care intervention focused on reducing hyperglyce...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/3/749 |
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| author | Amy L McKenzie Shaminie J Athinarayanan Jackson J McCue Rebecca N Adams Monica Keyes James P McCarter Jeff S Volek Stephen D Phinney Sarah J Hallberg |
| author_facet | Amy L McKenzie Shaminie J Athinarayanan Jackson J McCue Rebecca N Adams Monica Keyes James P McCarter Jeff S Volek Stephen D Phinney Sarah J Hallberg |
| author_sort | Amy L McKenzie |
| collection | DOAJ |
| description | The purpose of this study is to assess the effects of an alternative approach to type 2 diabetes prevention. Ninety-six patients with prediabetes (age 52 (10) years; 80% female; BMI 39.2 (7.1) kg/m<sup>2</sup>) received a continuous remote care intervention focused on reducing hyperglycemia through carbohydrate restricted nutrition therapy for two years in a single arm, prospective, longitudinal pilot study. Two-year retention was 75% (72 of 96 participants). Fifty-one percent of participants (49 of 96) met carbohydrate restriction goals as assessed by blood beta-hydroxybutyrate concentrations for more than one-third of reported measurements. Estimated cumulative incidence of normoglycemia (HbA1c < 5.7% without medication) and type 2 diabetes (HbA1c ≥ 6.5% or <6.5% with medication other than metformin) at two years were 52.3% and 3%, respectively. Prevalence of metabolic syndrome, class II or greater obesity, and suspected hepatic steatosis significantly decreased at two years. These results demonstrate the potential utility of an alternate approach to type 2 diabetes prevention, carbohydrate restricted nutrition therapy delivered through a continuous remote care model, for normalization of glycemia and improvement in related comorbidities. |
| first_indexed | 2024-03-09T00:30:14Z |
| format | Article |
| id | doaj.art-2dcc58ad776a4b49b1f7717d035c0970 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T00:30:14Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-2dcc58ad776a4b49b1f7717d035c09702023-12-11T18:33:52ZengMDPI AGNutrients2072-66432021-02-0113374910.3390/nu13030749Type 2 Diabetes Prevention Focused on Normalization of Glycemia: A Two-Year Pilot StudyAmy L McKenzie0Shaminie J Athinarayanan1Jackson J McCue2Rebecca N Adams3Monica Keyes4James P McCarter5Jeff S Volek6Stephen D Phinney7Sarah J Hallberg8Virta Health, San Francisco, CA 94105, USAVirta Health, San Francisco, CA 94105, USAUniversity of Washington School of Medicine Wyoming WWAMI, Laramie, WY 82071, USAVirta Health, San Francisco, CA 94105, USADepartment of Bariatric and Medical Weight Loss, Indiana University Health-Arnett, Lafayette, IN 47905, USADepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USAVirta Health, San Francisco, CA 94105, USAVirta Health, San Francisco, CA 94105, USAVirta Health, San Francisco, CA 94105, USAThe purpose of this study is to assess the effects of an alternative approach to type 2 diabetes prevention. Ninety-six patients with prediabetes (age 52 (10) years; 80% female; BMI 39.2 (7.1) kg/m<sup>2</sup>) received a continuous remote care intervention focused on reducing hyperglycemia through carbohydrate restricted nutrition therapy for two years in a single arm, prospective, longitudinal pilot study. Two-year retention was 75% (72 of 96 participants). Fifty-one percent of participants (49 of 96) met carbohydrate restriction goals as assessed by blood beta-hydroxybutyrate concentrations for more than one-third of reported measurements. Estimated cumulative incidence of normoglycemia (HbA1c < 5.7% without medication) and type 2 diabetes (HbA1c ≥ 6.5% or <6.5% with medication other than metformin) at two years were 52.3% and 3%, respectively. Prevalence of metabolic syndrome, class II or greater obesity, and suspected hepatic steatosis significantly decreased at two years. These results demonstrate the potential utility of an alternate approach to type 2 diabetes prevention, carbohydrate restricted nutrition therapy delivered through a continuous remote care model, for normalization of glycemia and improvement in related comorbidities.https://www.mdpi.com/2072-6643/13/3/749prediabetesremote continuous carelow carbohydratemetabolic syndromeobesity |
| spellingShingle | Amy L McKenzie Shaminie J Athinarayanan Jackson J McCue Rebecca N Adams Monica Keyes James P McCarter Jeff S Volek Stephen D Phinney Sarah J Hallberg Type 2 Diabetes Prevention Focused on Normalization of Glycemia: A Two-Year Pilot Study Nutrients prediabetes remote continuous care low carbohydrate metabolic syndrome obesity |
| title | Type 2 Diabetes Prevention Focused on Normalization of Glycemia: A Two-Year Pilot Study |
| title_full | Type 2 Diabetes Prevention Focused on Normalization of Glycemia: A Two-Year Pilot Study |
| title_fullStr | Type 2 Diabetes Prevention Focused on Normalization of Glycemia: A Two-Year Pilot Study |
| title_full_unstemmed | Type 2 Diabetes Prevention Focused on Normalization of Glycemia: A Two-Year Pilot Study |
| title_short | Type 2 Diabetes Prevention Focused on Normalization of Glycemia: A Two-Year Pilot Study |
| title_sort | type 2 diabetes prevention focused on normalization of glycemia a two year pilot study |
| topic | prediabetes remote continuous care low carbohydrate metabolic syndrome obesity |
| url | https://www.mdpi.com/2072-6643/13/3/749 |
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