The Vascular Circadian Clock in Chronic Kidney Disease
Chronic kidney disease is associated with extremely high cardiovascular mortality. The circadian rhythms (CR) have an impact on vascular function. The disruption of CR causes serious health problems and contributes to the development of cardiovascular diseases. Uremia may affect the master pacemaker...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/10/7/1769 |
| _version_ | 1797527363234299904 |
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| author | Søren Egstrand Maria L. Mace Klaus Olgaard Ewa Lewin |
| author_facet | Søren Egstrand Maria L. Mace Klaus Olgaard Ewa Lewin |
| author_sort | Søren Egstrand |
| collection | DOAJ |
| description | Chronic kidney disease is associated with extremely high cardiovascular mortality. The circadian rhythms (CR) have an impact on vascular function. The disruption of CR causes serious health problems and contributes to the development of cardiovascular diseases. Uremia may affect the master pacemaker of CR in the hypothalamus. A molecular circadian clock is also expressed in peripheral tissues, including the vasculature, where it regulates the different aspects of both vascular physiology and pathophysiology. Here, we address the impact of CKD on the intrinsic circadian clock in the vasculature. The expression of the core circadian clock genes in the aorta is disrupted in CKD. We propose a novel concept of the disruption of the circadian clock system in the vasculature of importance for the pathology of the uremic vasculopathy. |
| first_indexed | 2024-03-10T09:42:54Z |
| format | Article |
| id | doaj.art-2dcfdfdaa987499cba542e968cccf469 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T09:42:54Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-2dcfdfdaa987499cba542e968cccf4692023-11-22T03:29:46ZengMDPI AGCells2073-44092021-07-01107176910.3390/cells10071769The Vascular Circadian Clock in Chronic Kidney DiseaseSøren Egstrand0Maria L. Mace1Klaus Olgaard2Ewa Lewin3Nephrological Department B, Herlev Hospital, University of Copenhagen, 2730 Copenhagen, DenmarkNephrological Department P, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, DenmarkNephrological Department P, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, DenmarkNephrological Department B, Herlev Hospital, University of Copenhagen, 2730 Copenhagen, DenmarkChronic kidney disease is associated with extremely high cardiovascular mortality. The circadian rhythms (CR) have an impact on vascular function. The disruption of CR causes serious health problems and contributes to the development of cardiovascular diseases. Uremia may affect the master pacemaker of CR in the hypothalamus. A molecular circadian clock is also expressed in peripheral tissues, including the vasculature, where it regulates the different aspects of both vascular physiology and pathophysiology. Here, we address the impact of CKD on the intrinsic circadian clock in the vasculature. The expression of the core circadian clock genes in the aorta is disrupted in CKD. We propose a novel concept of the disruption of the circadian clock system in the vasculature of importance for the pathology of the uremic vasculopathy.https://www.mdpi.com/2073-4409/10/7/1769vascular calcificationccl2inflammationadhesion moleculesVCAM-1ICAM-1 |
| spellingShingle | Søren Egstrand Maria L. Mace Klaus Olgaard Ewa Lewin The Vascular Circadian Clock in Chronic Kidney Disease Cells vascular calcification ccl2 inflammation adhesion molecules VCAM-1 ICAM-1 |
| title | The Vascular Circadian Clock in Chronic Kidney Disease |
| title_full | The Vascular Circadian Clock in Chronic Kidney Disease |
| title_fullStr | The Vascular Circadian Clock in Chronic Kidney Disease |
| title_full_unstemmed | The Vascular Circadian Clock in Chronic Kidney Disease |
| title_short | The Vascular Circadian Clock in Chronic Kidney Disease |
| title_sort | vascular circadian clock in chronic kidney disease |
| topic | vascular calcification ccl2 inflammation adhesion molecules VCAM-1 ICAM-1 |
| url | https://www.mdpi.com/2073-4409/10/7/1769 |
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