Ephrin B Activate Src Family Kinases in Fibroblasts Inducing Stromal Remodeling in Prostate Cancer

Ephrin B Activate Src Family Kinases in Fibroblasts Inducing Stromal Remodeling in Prostate Cancer

Through stromal-epithelial interactions, carcinoma associated fibroblasts (CAF) play a critical role in tumor growth and progression. Activation of erythrophoyetin-producing human hepatocellular (Eph) receptors has been implicated in cancer. Eph receptor interactions with Ephrin ligands lead to bidi...

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Bibliographic Details
Main Authors: Mamatha Kakarla, Sathyavathi ChallaSivaKanaka, Mary F. Dufficy, Victoria Gil, Yana Filipovich, Renee Vickman, Susan E. Crawford, Simon W. Hayward, Omar E. Franco
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cancers
Subjects:
tumor microenvironment (TME)
carcinoma-associated fibroblasts (CAF)
stroma
prostate cancer
Ephrins
reverse signaling
Online Access:https://www.mdpi.com/2072-6694/14/9/2336

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