The Characteristics of PD-L1 Inhibitors, from Peptides to Small Molecules
The programmed cell death ligand protein 1 (PD-L1) is a member of the B7 protein family and consists of 290 amino acid residues. The blockade of the PD-1/PD-L1 immune checkpoint pathway is effective in tumor treatment. Results: Two pharmacophore models were generated based on peptides and small mole...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/10/1940 |
| _version_ | 1828163468907249664 |
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| author | Yanwen Zhong Xuanyi Li Hequan Yao Kejiang Lin |
| author_facet | Yanwen Zhong Xuanyi Li Hequan Yao Kejiang Lin |
| author_sort | Yanwen Zhong |
| collection | DOAJ |
| description | The programmed cell death ligand protein 1 (PD-L1) is a member of the B7 protein family and consists of 290 amino acid residues. The blockade of the PD-1/PD-L1 immune checkpoint pathway is effective in tumor treatment. Results: Two pharmacophore models were generated based on peptides and small molecules. Hypo 1A consists of one hydrogen bond donor, one hydrogen bond acceptor, two hydrophobic points and one aromatic ring point. Hypo 1B consists of one hydrogen bond donor, three hydrophobic points and one positive ionizable point. Conclusions: The pharmacophore model consisting of a hydrogen bond donor, hydrophobic points and a positive ionizable point may be helpful for designing small-molecule inhibitors targeting PD-L1. |
| first_indexed | 2024-04-12T01:10:45Z |
| format | Article |
| id | doaj.art-2dd2cc306a804dd5a9446fa9eb306bb5 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-12T01:10:45Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-2dd2cc306a804dd5a9446fa9eb306bb52022-12-22T03:54:07ZengMDPI AGMolecules1420-30492019-05-012410194010.3390/molecules24101940molecules24101940The Characteristics of PD-L1 Inhibitors, from Peptides to Small MoleculesYanwen Zhong0Xuanyi Li1Hequan Yao2Kejiang Lin3Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, ChinaDepartment of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, ChinaDepartment of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, ChinaDepartment of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, ChinaThe programmed cell death ligand protein 1 (PD-L1) is a member of the B7 protein family and consists of 290 amino acid residues. The blockade of the PD-1/PD-L1 immune checkpoint pathway is effective in tumor treatment. Results: Two pharmacophore models were generated based on peptides and small molecules. Hypo 1A consists of one hydrogen bond donor, one hydrogen bond acceptor, two hydrophobic points and one aromatic ring point. Hypo 1B consists of one hydrogen bond donor, three hydrophobic points and one positive ionizable point. Conclusions: The pharmacophore model consisting of a hydrogen bond donor, hydrophobic points and a positive ionizable point may be helpful for designing small-molecule inhibitors targeting PD-L1.https://www.mdpi.com/1420-3049/24/10/1940programmed cell death ligand protein 1pharmacophorepeptidesmall molecule |
| spellingShingle | Yanwen Zhong Xuanyi Li Hequan Yao Kejiang Lin The Characteristics of PD-L1 Inhibitors, from Peptides to Small Molecules Molecules programmed cell death ligand protein 1 pharmacophore peptide small molecule |
| title | The Characteristics of PD-L1 Inhibitors, from Peptides to Small Molecules |
| title_full | The Characteristics of PD-L1 Inhibitors, from Peptides to Small Molecules |
| title_fullStr | The Characteristics of PD-L1 Inhibitors, from Peptides to Small Molecules |
| title_full_unstemmed | The Characteristics of PD-L1 Inhibitors, from Peptides to Small Molecules |
| title_short | The Characteristics of PD-L1 Inhibitors, from Peptides to Small Molecules |
| title_sort | characteristics of pd l1 inhibitors from peptides to small molecules |
| topic | programmed cell death ligand protein 1 pharmacophore peptide small molecule |
| url | https://www.mdpi.com/1420-3049/24/10/1940 |
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