Hypoglycaemic and hypotriglyceridaemic postprandial properties of organic silicon
The positive effects of Si on cardiovascular disease (CVD) and diabetes mellitus (DM) have been mooted. However, the effect of Si on postprandial state has not been evaluated. Postprandial hypertriglyceridaemia and hyperglycaemia are considered risk factors for cardiovascular disease. The effects of...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-02-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S175646461630439X |
| _version_ | 1819292772764483584 |
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| author | Alba Garcimartín M. Elvira López-Oliva Adrián Macho-González Sara Bastida Juana Benedí Francisco J. Sánchez-Muniz |
| author_facet | Alba Garcimartín M. Elvira López-Oliva Adrián Macho-González Sara Bastida Juana Benedí Francisco J. Sánchez-Muniz |
| author_sort | Alba Garcimartín |
| collection | DOAJ |
| description | The positive effects of Si on cardiovascular disease (CVD) and diabetes mellitus (DM) have been mooted. However, the effect of Si on postprandial state has not been evaluated. Postprandial hypertriglyceridaemia and hyperglycaemia are considered risk factors for cardiovascular disease. The effects of Si supplementation on postprandial hypertriglyceridaemia and hyperglycaemia were tested in two groups of 6 healthy male Wistar rats after acute and 1-week administrations. In the postprandial study rats were administered 1 ml of olive oil and glucose solution (0.5 g/kg bw) by oral gavage. The results indicate that Si reduced glucose and triglycerides digestion and absorption from the first dose, although the effects were stronger after 1-week treatment. This study clearly suggests Si supplementation can be a powerful tool in the management of postprandial hypertriglyceridaemia and hyperglycaemia. |
| first_indexed | 2024-12-24T03:59:51Z |
| format | Article |
| id | doaj.art-2dd340d8d3d04c5e979ce3f8e8ebd666 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-24T03:59:51Z |
| publishDate | 2017-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-2dd340d8d3d04c5e979ce3f8e8ebd6662022-12-21T17:16:21ZengElsevierJournal of Functional Foods1756-46462017-02-0129290294Hypoglycaemic and hypotriglyceridaemic postprandial properties of organic siliconAlba Garcimartín0M. Elvira López-Oliva1Adrián Macho-González2Sara Bastida3Juana Benedí4Francisco J. Sánchez-Muniz5Depatamento de Farmacología, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain; Departamento de Nutrición y Bromatología I (Nutrición), Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, SpainSección Departamental de Fisiología, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, SpainDepartamento de Nutrición y Bromatología I (Nutrición), Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, SpainDepartamento de Nutrición y Bromatología I (Nutrición), Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, SpainDepatamento de Farmacología, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, SpainDepartamento de Nutrición y Bromatología I (Nutrición), Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain; Corresponding author.The positive effects of Si on cardiovascular disease (CVD) and diabetes mellitus (DM) have been mooted. However, the effect of Si on postprandial state has not been evaluated. Postprandial hypertriglyceridaemia and hyperglycaemia are considered risk factors for cardiovascular disease. The effects of Si supplementation on postprandial hypertriglyceridaemia and hyperglycaemia were tested in two groups of 6 healthy male Wistar rats after acute and 1-week administrations. In the postprandial study rats were administered 1 ml of olive oil and glucose solution (0.5 g/kg bw) by oral gavage. The results indicate that Si reduced glucose and triglycerides digestion and absorption from the first dose, although the effects were stronger after 1-week treatment. This study clearly suggests Si supplementation can be a powerful tool in the management of postprandial hypertriglyceridaemia and hyperglycaemia.http://www.sciencedirect.com/science/article/pii/S175646461630439XOrganic siliconPostprandial studyHyperglycaemiaHypertriglyceridaemiaWistar rat |
| spellingShingle | Alba Garcimartín M. Elvira López-Oliva Adrián Macho-González Sara Bastida Juana Benedí Francisco J. Sánchez-Muniz Hypoglycaemic and hypotriglyceridaemic postprandial properties of organic silicon Journal of Functional Foods Organic silicon Postprandial study Hyperglycaemia Hypertriglyceridaemia Wistar rat |
| title | Hypoglycaemic and hypotriglyceridaemic postprandial properties of organic silicon |
| title_full | Hypoglycaemic and hypotriglyceridaemic postprandial properties of organic silicon |
| title_fullStr | Hypoglycaemic and hypotriglyceridaemic postprandial properties of organic silicon |
| title_full_unstemmed | Hypoglycaemic and hypotriglyceridaemic postprandial properties of organic silicon |
| title_short | Hypoglycaemic and hypotriglyceridaemic postprandial properties of organic silicon |
| title_sort | hypoglycaemic and hypotriglyceridaemic postprandial properties of organic silicon |
| topic | Organic silicon Postprandial study Hyperglycaemia Hypertriglyceridaemia Wistar rat |
| url | http://www.sciencedirect.com/science/article/pii/S175646461630439X |
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