The effect of a diet supplement containing S-acetyl-glutathione (SAG) and other antioxidant natural ingredients on glutathione peroxidase in healthy dogs: a pilot study
Oxidative stress is common in several human and veterinary conditions and it is associated to alteration of the glutathione peroxidase (GPx) level. GPx is an enzyme present in erythrocytes, kidney, and liver and it has a role in protecting against oxidative damage. In this randomised double-blinded...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
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| Series: | Italian Journal of Animal Science |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/1828051X.2023.2221073 |
| _version_ | 1797198493091102720 |
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| author | Francesca Perondi Donal Bisanzio Raffaella Adami Ilaria Lippi Giorgia Meineri Monica Isabella Cutrignelli Selena Massa Elisa Martello |
| author_facet | Francesca Perondi Donal Bisanzio Raffaella Adami Ilaria Lippi Giorgia Meineri Monica Isabella Cutrignelli Selena Massa Elisa Martello |
| author_sort | Francesca Perondi |
| collection | DOAJ |
| description | Oxidative stress is common in several human and veterinary conditions and it is associated to alteration of the glutathione peroxidase (GPx) level. GPx is an enzyme present in erythrocytes, kidney, and liver and it has a role in protecting against oxidative damage. In this randomised double-blinded control trial on healthy dogs, we present findings indicating that the administration for a total of 35 days of a supplement containing S-acetyl-glutathione (SAG) alongside other antioxidant natural ingredients, leads to an increase in the GPx level. Furthermore, the supplement positively changes liver blood parameters, even in healthy dogs. These preliminary results hold promise for conducting new studies using the same supplement on dogs affected by liver conditions, thereby confirming its antioxidant effects and the potential improvement of altered blood parameters.HIGHLIGHTS Oxidative stress characterises several conditions in dogs and the use of antioxidants can improve their health. The administration of a new supplement containing S-acetyl-glutathione (SAG) together with other antioxidant natural ingredients, increased the level of glutathione peroxidase (GPx). No adverse events were reported after the supplement administration. |
| first_indexed | 2024-03-08T16:59:42Z |
| format | Article |
| id | doaj.art-2dd38049394b4a75864ff02e2d2570c4 |
| institution | Directory Open Access Journal |
| issn | 1594-4077 1828-051X |
| language | English |
| last_indexed | 2024-04-24T07:00:44Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Italian Journal of Animal Science |
| spelling | doaj.art-2dd38049394b4a75864ff02e2d2570c42024-04-22T08:52:28ZengTaylor & Francis GroupItalian Journal of Animal Science1594-40771828-051X2023-12-0122158959310.1080/1828051X.2023.22210732221073The effect of a diet supplement containing S-acetyl-glutathione (SAG) and other antioxidant natural ingredients on glutathione peroxidase in healthy dogs: a pilot studyFrancesca Perondi0Donal Bisanzio1Raffaella Adami2Ilaria Lippi3Giorgia Meineri4Monica Isabella Cutrignelli5Selena Massa6Elisa Martello7Department of Veterinary Science, University of PisaRTI InternationalCandioli Pharma S.r.lDepartment of Veterinary Science, University of PisaDepartment of Veterinary Sciences, University of TurinDepartment of Veterinary Medicine and Animal Production, University of Napoli Federico IIVeterinary PractitionerDivision of Epidemiology and Public Health, School of Medicine, University of NottinghamOxidative stress is common in several human and veterinary conditions and it is associated to alteration of the glutathione peroxidase (GPx) level. GPx is an enzyme present in erythrocytes, kidney, and liver and it has a role in protecting against oxidative damage. In this randomised double-blinded control trial on healthy dogs, we present findings indicating that the administration for a total of 35 days of a supplement containing S-acetyl-glutathione (SAG) alongside other antioxidant natural ingredients, leads to an increase in the GPx level. Furthermore, the supplement positively changes liver blood parameters, even in healthy dogs. These preliminary results hold promise for conducting new studies using the same supplement on dogs affected by liver conditions, thereby confirming its antioxidant effects and the potential improvement of altered blood parameters.HIGHLIGHTS Oxidative stress characterises several conditions in dogs and the use of antioxidants can improve their health. The administration of a new supplement containing S-acetyl-glutathione (SAG) together with other antioxidant natural ingredients, increased the level of glutathione peroxidase (GPx). No adverse events were reported after the supplement administration.http://dx.doi.org/10.1080/1828051X.2023.2221073dietoral administrationoxidative stresspetgpx |
| spellingShingle | Francesca Perondi Donal Bisanzio Raffaella Adami Ilaria Lippi Giorgia Meineri Monica Isabella Cutrignelli Selena Massa Elisa Martello The effect of a diet supplement containing S-acetyl-glutathione (SAG) and other antioxidant natural ingredients on glutathione peroxidase in healthy dogs: a pilot study Italian Journal of Animal Science diet oral administration oxidative stress pet gpx |
| title | The effect of a diet supplement containing S-acetyl-glutathione (SAG) and other antioxidant natural ingredients on glutathione peroxidase in healthy dogs: a pilot study |
| title_full | The effect of a diet supplement containing S-acetyl-glutathione (SAG) and other antioxidant natural ingredients on glutathione peroxidase in healthy dogs: a pilot study |
| title_fullStr | The effect of a diet supplement containing S-acetyl-glutathione (SAG) and other antioxidant natural ingredients on glutathione peroxidase in healthy dogs: a pilot study |
| title_full_unstemmed | The effect of a diet supplement containing S-acetyl-glutathione (SAG) and other antioxidant natural ingredients on glutathione peroxidase in healthy dogs: a pilot study |
| title_short | The effect of a diet supplement containing S-acetyl-glutathione (SAG) and other antioxidant natural ingredients on glutathione peroxidase in healthy dogs: a pilot study |
| title_sort | effect of a diet supplement containing s acetyl glutathione sag and other antioxidant natural ingredients on glutathione peroxidase in healthy dogs a pilot study |
| topic | diet oral administration oxidative stress pet gpx |
| url | http://dx.doi.org/10.1080/1828051X.2023.2221073 |
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